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Autor:
Alexander Stein, Maurice Michel, Jens U. Marquardt, Helge Schroeder, Oliver Waidmann, Marcus-Alexander Woerns, Arndt Weinmann, Markus Moehler, Martin Maenz, Joseph Tintelnot, Friedrich Foerster, Joerg Trojan
Publikováno v:
Future Oncology. 17:3309-3319
Aim: To determine a recommended Phase II dose of the oral fluoropyrimidine trifluridine/tipiracil (FTD/TPI) combined with the multi-kinase inhibitor regorafenib (REG) in refractory metastatic colorectal cancer patients. Materials & methods: A convent
Publikováno v:
Journal of Oncology Pharmacy Practice. 27:1806-1809
Introduction Salivary gland neoplasms (SGNs) respond poorly to the traditional chemotherapy agents limiting the availability of systemic treatment options in the metastatic setting. The recent identification of actionable molecular targets in SGNs ha
Autor:
Geraldine M. Jacobson, Gary Marano, Timothy D. Eubank, Malcolm D. Mattes, Patrick C. Ma, Mohammed Almubarak, Sijin Wen
Publikováno v:
Clin Lung Cancer
INTRODUCTION/BACKGROUND: This study assessed the safety and systemic (abscopal) response from the addition of local stereotactic body radiation therapy (SBRT) to checkpoint inhibitor (CPI) immunotherapy in patients with metastatic non-small cell lung
Autor:
Daniel J. Lenihan, Avirup Guha, Jahir M. Gutierrez, Sadeer G. Al-Kindi, Guilherme H. Oliveira, Chhavi Jain, Marcos de Lima, Afshin Dowlati, Michael G. Fradley, Jill S. Barnholtz-Sloan, Prantesh Jain
Publikováno v:
Cancer Medicine, Vol 10, Iss 12, Pp 3862-3872 (2021)
Cancer Medicine
Cancer Medicine
Background Cardiovascular adverse events (CVAEs) associated with BRAF inhibitors alone versus combination BRAF/MEK inhibitors are not fully understood. Methods This study included all adult patients who received BRAF inhibitors (vemurafenib, dabrafen
Autor:
Zeev Estrov, Prithviraj Bose, Varsha Gandhi, Jan A. Burger, Xuemei Wang, Naveen Garg, Rashmi Kanagal-Shamanna, Naveen Pemmaraju, Philip A. Thompson, Ana Ayala, Hagop M. Kantarjian, Koji Sasaki, Keyur P. Patel, Tapan M. Kadia, Alessandra Ferrajoli, Susan O'Brien, Elias Jabbour, Gautam Borthakur, Koichi Takahashi, Marina Konopleva, Wanda Lopez, Michael J. Keating, Wei Wang, William G. Wierda, Nitin Jain, Jeffrey L. Jorgensen, William Plunkett, Sa Wang
Publikováno v:
Leukemia. 35:3421-3429
Chemoimmunotherapy with combined fludarabine, cyclophosphamide and rituximab (FCR) has been an effective treatment for patients with chronic lymphocytic leukemia (CLL). We initiated a phase II trial for previously untreated patients with CLL with mut
Autor:
Christopher Sweeney, Eric Winquist, Darren R. Feldman, Ugo De Giorgi, Daniel Y.C. Heng, Silke Gillessen, Michal Chovanec, Jourik A. Gietema, Robert Huddart, Costantine Albany, Fay H. Cafferty, Peter Grimison, Aaron R. Hansen, Carsten Bokemeyer, Karim Fizazi, Jörg Beyer, Christian D. Fankhauser, Nicolas Sauvé, Alexey Tryakin, Torgrim Tandstad, Olof Ståhl, Helene F. S. Negaard, Ronald de Wit, Anja Lorch, Andrea Necchi, David J. Vaughn, Angelika Terbuch, Axel Heidenreich, Cora N. Sternberg, Marcus Hentrich, Xavier Garcia-del-Muro, Gedske Daugaard, Laurence Collette, Jonathan Shamash
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
J Clin Oncol
Gillessen, Silke; Sauvé, Nicolas; Collette, Laurence; Daugaard, Gedske; de Wit, Ronald; Albany, Costantine; Tryakin, Alexey; Fizazi, Karim; Stahl, Olof; Gietema, Jourik A; De Giorgi, Ugo; Cafferty, Fay H; Hansen, Aaron R; Tandstad, Torgrim; Huddart, Robert A; Necchi, Andrea; Sweeney, Christopher J; Garcia-Del-Muro, Xavier; Heng, Daniel Y C; Lorch, Anja; ... (2021). Predicting Outcomes in Men With Metastatic Nonseminomatous Germ Cell Tumors (NSGCT): Results From the IGCCCG Update Consortium. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 39(14), pp. 1563-1574. 10.1200/JCO.20.03296
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 39(14), 1563-+. AMER SOC CLINICAL ONCOLOGY
Universidad de Barcelona
J Clin Oncol
Gillessen, Silke; Sauvé, Nicolas; Collette, Laurence; Daugaard, Gedske; de Wit, Ronald; Albany, Costantine; Tryakin, Alexey; Fizazi, Karim; Stahl, Olof; Gietema, Jourik A; De Giorgi, Ugo; Cafferty, Fay H; Hansen, Aaron R; Tandstad, Torgrim; Huddart, Robert A; Necchi, Andrea; Sweeney, Christopher J; Garcia-Del-Muro, Xavier; Heng, Daniel Y C; Lorch, Anja; ... (2021). Predicting Outcomes in Men With Metastatic Nonseminomatous Germ Cell Tumors (NSGCT): Results From the IGCCCG Update Consortium. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 39(14), pp. 1563-1574. 10.1200/JCO.20.03296
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 39(14), 1563-+. AMER SOC CLINICAL ONCOLOGY
PURPOSE The classification of the International Germ Cell Cancer Collaborative Group (IGCCCG) plays a pivotal role in the management of metastatic germ cell tumors but relies on data of patients treated between 1975 and 1990. MATERIALS AND METHODS Da
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-8 (2021)
BMC Cancer
BMC Cancer
Background Regorafenib has shown promising results as a second-line therapy for patients with hepatocellular carcinoma (HCC) who progressed on sorafenib. Although there have been several data regarding the efficacy of sequential therapy with sorafeni
Autor:
Karen-Lise Garm Spindler, Eva Serup-Hansen, Camilla Kronborg, Katrine Smedegaard Storm, Birgitte Mayland Havelund, Christina Glismand Truelsen
Publikováno v:
Cancer Medicine, Vol 10, Iss 10, Pp 3224-3230 (2021)
Cancer Medicine
Truelsen, C G, Serup-Hansen, E, Storm, K S, Havelund, B M, Kronborg, C S & Spindler, K L G 2021, ' Nonplatinum-based therapy with Paclitaxel and Capecitabine for advanced squamous cell carcinomas of the anal canal : A population-based Danish anal cancer group study ', Cancer Medicine, vol. 10, no. 10, pp. 3224-3230 . https://doi.org/10.1002/cam4.3886
Cancer Medicine
Truelsen, C G, Serup-Hansen, E, Storm, K S, Havelund, B M, Kronborg, C S & Spindler, K L G 2021, ' Nonplatinum-based therapy with Paclitaxel and Capecitabine for advanced squamous cell carcinomas of the anal canal : A population-based Danish anal cancer group study ', Cancer Medicine, vol. 10, no. 10, pp. 3224-3230 . https://doi.org/10.1002/cam4.3886
Background First‐line platinum‐based therapy for advanced squamous cell carcinomas of the anal canal (SCCA) implies a risk of substantial side effects, and data on second‐line treatment options are limited. Paclitaxel and Capecitabine are a wel
Autor:
Shunichi Sugawara, Junji Kishimoto, Hajime Asahina, Kenji Sugio, Yukari Tsubata, Yoshihiro Miyata, Kana Watanabe, Kosuke Hamai, Taishi Harada, Takahiro Uchida, Isamu Okamoto, Satoshi Oizumi, Kentaro Tanaka, Kunihiko Kobayashi
Publikováno v:
European Journal of Cancer. 149:14-22
Background Osimertinib is now a standard treatment for patients with previously untreated EGFR-mutated advanced non–small cell lung cancer (NSCLC). We here investigated whether the combination of osimertinib with cytotoxic chemotherapy might hold a
Autor:
Natalie Andrews Wright, Prisni Rath, Trevor J. Pugh, Glenwood D. Goss, Gemma N Jones, Harmanjatinder S. Sekhon, Natalia Lukashchuk, Kayla Marsh, Bryan Lo, Paola Marco-Casanova, Laurence Bernard, William J. Howat, Dax Torti, Jonathon Torchia, Marc Duciaume, Alberto Leon, Darren Hodgson, Stanley E. Lazic, Johanne I Weberpals, Doreen Whelan, Alexander Fortuna, Martine P. Roudier
Publikováno v:
Cancer Medicine
Cancer Medicine, Vol 10, Iss 9, Pp 3045-3058 (2021)
Cancer Medicine, Vol 10, Iss 9, Pp 3045-3058 (2021)
Background In high grade serous ovarian cancer (HGSOC), there is a spectrum of sensitivity to first line platinum‐based chemotherapy. This study molecularly characterizes HGSOC patients from two distinct groups of chemotherapy responders (good vs.