Zobrazeno 1 - 10
of 209
pro vyhledávání: '"Preclinical research"'
Autor:
Greg Jensen, Vincent P. Ferrera, Nancy Kwon, Mark Burgess, Elisa E. Konofagou, Robin Ji, Fabian Munoz, Hermes A. S. Kamimura, Andrew F. Teich, Antonios N. Pouliopoulos, Alicia J McLuckie, Anna Meaney, Yusuke Niimi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Scientific Reports
Scientific Reports
An emerging approach with potential in improving the treatment of neurodegenerative diseases and brain tumors is the use of focused ultrasound (FUS) to bypass the blood–brain barrier (BBB) in a non-invasive and localized manner. A large body of pre
Autor:
Lee E. Fisher, Liane Wong, Bryan McLaughlin, Charles C. Horn, Jonathan A. Shulgach, Michael Sciullo, Derek M. Miller, Ameya C. Nanivadekar, Bill J. Yates, Dylan W. Beam, John I. Ogren, Stephanie Fulton
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports
Scientific Reports
Dysfunction and diseases of the gastrointestinal (GI) tract are a major driver of medical care. The vagus nerve innervates and controls multiple organs of the GI tract and vagus nerve stimulation (VNS) could provide a means for affecting GI function
Autor:
Timir Datta-Chaudhuri
Publikováno v:
Bioelectronic Medicine, Vol 7, Iss 1, Pp 1-10 (2021)
Bioelectronic Medicine
Bioelectronic Medicine
Mouse models have been of tremendous benefit to medical science for the better part of a century, yet bioelectronic medicine research using mice has been limited to mostly acute studies because of a lack of tools for chronic stimulation and sensing.
Autor:
Opa Vajragupta, Peththa Wadu Dasuni Wasana, Pornchai Rojsitthisak, Pasarapa Towiwat, Hasriadi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Scientific Reports
Scientific Reports
The failure to develop analgesic drugs is attributed not only to the complex and diverse pathophysiology of pain in humans but also to the poor experimental design and poor preclinical assessment of pain. Although considerable efforts have been devot
Publikováno v:
Cellular and Molecular Neurobiology. 42:2003-2017
Despite achieving remarkable success in understanding the cellular, molecular and pathophysiological aspects of stroke, translation from preclinical research has always remained an area of debate. Although thousands of experimental compounds have bee
Autor:
Manuel Desco, Marta Casquero-Veiga, Diego Romero-Miguel, Clara Bueno-Fernandez, Juan Nacher, Nicolás Lamanna-Rama, María Luisa Soto-Montenegro
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
e-Archivo. Repositorio Institucional de la Universidad Carlos III de Madrid
instname
Scientific Reports
Repisalud
Instituto de Salud Carlos III (ISCIII)
e-Archivo. Repositorio Institucional de la Universidad Carlos III de Madrid
instname
Scientific Reports
Repisalud
Instituto de Salud Carlos III (ISCIII)
Deep brain stimulation (DBS) is a powerful neurostimulation therapy proposed for the treatment of several neuropsychiatric disorders. However, DBS mechanism of action remains unclear, being its effects on brain dynamics of particular interest. Specif
Autor:
Romain-Daniel Gosselin
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Scientific Reports
Scientific Reports
Non-transparent statistical reporting contributes to the reproducibility crisis in life sciences, despite guidelines and educational articles regularly published. Envisioning more effective measures for ensuring transparency requires the detailed mon
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports
Extensive studies on focused ultrasound (FUS)-mediated drug delivery through the blood–brain barrier have been published, yet little work has been published on FUS-mediated drug delivery through the blood-spinal cord barrier (BSCB). This work aims
Publikováno v:
Physiol Res
The main role of research in medicine is to provide relevant knowledge which, after successful translation to clinical practice, improves the quality of healthcare. The sex bias which is still present in the majority of research disciplines prefers m
Autor:
Julia A. Tree, Tomas Malinauskas, Mark Howarth, Adrian K. Zagrajek, Veronica Martini, John W. McCauley, Ryan Waters, Jiandong Huo, Jane C. Edwards, Ginette Wilsden, Holly Shelton, Alison Burman, Anna B. Ludi, Rolle Rahikainen, Rod S. Daniels, Isabelle Dietrich, Huang K-Ya., David I. Stuart, Simon P. Graham, M. Pedrera, Valerie Mioulet, Raymond J. Owens, Christopher Chiu, Pramila Rijal, Nazia Thakur, Philippa Hollinghurst, Sushant Bhat, Hayes Jwp., Matthew Tully, Alain Townsend, Miles W. Carroll, Saira Hussain, Clare Browning, Tobias J. Tuthill, Tiong Kit Tan, Katy Moffat, Dagmara Bialy, Rebecca K. McLean, Elma Tchilian, Karen R. Buttigieg, Sylvia Crossley, Ashley R. Gray, Carina Conceicao, Joseph Newman, Phoebe Stevenson-Leggett, Ruth Harvey, Bryan Charleston, Mehreen Azhar, Dalan Bailey, Amin S. Asfor, Duyvesteyn Hme., Anthony H. Keeble, John A. Hammond, Lisa Schimanski
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
Nature Communications
There is need for effective and affordable vaccines against SARS-CoV-2 to tackle the ongoing pandemic. In this study, we describe a protein nanoparticle vaccine against SARS-CoV-2. The vaccine is based on the display of coronavirus spike glycoprotein