Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Xiaofeng Tian"'
Autor:
Zhao Chen, Xiaodong Ma, Li Lv, Xiaofeng Tian, Fan Tang, Huanyu Zhao, Yang Li, Jihong Yao, Zhecheng Wang, Junjun Zhou, Dongcheng Feng, Yan Zhao
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 21, Iss, Pp 751-763 (2020)
Molecular Therapy. Nucleic Acids
Molecular Therapy. Nucleic Acids
We previously found that inhibition of p66Shc confers protection against hepatic stellate cell (HSC) activation during liver fibrosis. However, the effect of p66Shc on HSC proliferation, as well as the mechanism by which p66Shc is modulated, remains
Autor:
Yue Wang, Yan Zhao, Zhecheng Wang, Ruimin Sun, Boyang Zou, Ruixi Li, Deshun Liu, Musen Lin, Junjun Zhou, Shili Ning, Xiaofeng Tian, Jihong Yao
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
Frontiers in Immunology
Pyroptosis is a newly discovered form of cell death. Peroxiredoxin 3 (PRX3) plays a crucial role in scavenging reactive oxygen species (ROS), but its hepatoprotective capacity in acetaminophen (APAP)-induced liver disease remains unclear. The aim of
Autor:
Junjun Zhou, Yan Zhao, Ruimin Sun, Jihong Yao, Dongcheng Feng, Rong Fu, Xiaofeng Tian, Zhecheng Wang, Ruiwen Wang, Li Lv
Publikováno v:
Oxidative Medicine and Cellular Longevity, Vol 2019 (2019)
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity
Alcohol abuse has become common worldwide and has been recognized as a major cause of chronic alcoholic liver disease (ALD). ALD encompasses a complex process that includes a broad scope of hepatic lesions, ranging from steatosis to cirrhosis. In par
Autor:
Tong Li, Xiaofeng Tian, Guo Zu, Anlong Ji, Yang Li, Guangzhi Wang, Dongcheng Feng, Jihong Yao
Publikováno v:
World Journal of Gastroenterology
BACKGROUND Intestinal ischemia reperfusion (I/R) injury is a serious but common pathophysiological process of many diseases, resulting in a high mortality rate in clinical practice. Ubiquitin-specific protease 22 (USP22) acts as regulator of cell cyc
p66Shc Contributes to Liver Fibrosis through the Regulation of Mitochondrial Reactive Oxygen Species
Autor:
Zhenming Gao, Xiaofeng Tian, Zhecheng Wang, Li Lv, Dongcheng Feng, Huanyu Zhao, Ning Zhang, Yan Hu, Xiaohan Zhai, Jihong Yao, Yan Zhao, Musen Lin
Publikováno v:
Theranostics
Background: p66Shc is a redox enzyme that mediates mitochondrial reactive oxygen species (ROS) generation. p66Shc inhibition confers protection against liver injury, however, its functional contribution to liver fibrosis remains unclear. The aim of t
Autor:
Yongfu Zhao, Guangzhi Wang, Zhenlu Li, Xiaofeng Tian, Dongcheng Feng, Jihong Yao, Yang Li, Wasim Qasim
Publikováno v:
Cellular Physiology and Biochemistry, Vol 48, Iss 4, Pp 1579-1594 (2018)
Background/Aims: Ischemic postconditioning (iPoC) represents a promising strategy to mitigate ischemia/reperfusion (I/R) injury of the intestine, yet the mechanisms of this treatment remain to be elucidated. Circular RNAs (circRNAs), a novel class of
Autor:
Yan Zhao, Yan Hu, Zhao Chen, Yang Li, Shili Ning, Jihong Yao, Zhecheng Wang, Deshun Liu, Xiaofeng Tian, Dongcheng Feng
Publikováno v:
Theranostics
Background: Oxidative stress has emerged as an essential factor in the pathogenesis of intestinal ischemia/reperfusion (I/R) injury. The adaptor protein p66Shc is a key regulator of reactive oxygen species (ROS) generation and a mediator of I/R damag
Autor:
Deshun Liu, Yan Zhao, Ruimin Sun, Jihong Yao, Huanyu Zhao, Guangzhi Wang, Zhao Chen, Yang Li, Zhanyu Wang, Xiaofeng Tian, Feng Zhang
Publikováno v:
Redox Biology, Vol 28, Iss, Pp-(2020)
Redox Biology
Redox Biology
Background: Hydrogen peroxide (H2O2)-induced mitochondrial oxidative damage is critical to intestinal ischemia/reperfusion (I/R) injury, and PRDX3 is an efficient H2O2 scavenger that protects cells from mitochondrial oxidative damage and apoptosis. H
Autor:
Zhenlu Li, Xue Shi, Anlong Ji, Chunchun Ding, Dongyan Gao, Yang Li, Junjun Zhou, Jihong Yao, Zhecheng Wang, Dongcheng Feng, Xiaofeng Tian, Yan Zhao
Publikováno v:
Toxicology and Applied Pharmacology. 350:21-31
In recent years, alcoholic liver disease (ALD) has emerged as a growing public health problem worldwide. β-catenin plays an important role in the growth, development, regeneration and metabolic activity of the liver. Salvianolic acid A (SalA) is a w
Autor:
Junjun Zhou, Yang Li, Zhecheng Wang, Ruimin Sun, Yan Zhao, Jihong Yao, Xiaohui Kang, Rong Fu, Zhanyu Wang, Yan Hu, Ruiwen Wang, Xiaofeng Tian, Wen Shan
Publikováno v:
Br J Pharmacol
Background and purpose Hepatic fatty acid metabolism disorder, a key pathogenic mechanism underlying non-alcoholic fatty liver disease (NAFLD), is associated with the hyperacetylation of mitochondrial enzymes. Acyl-CoA synthetase family member 3 (ACS