Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Wendie N. Marks"'
Autor:
Terrance P. Snutch, Changiz Taghibiglou, Sathiya Sekar, John G. Howland, Venkat Gopalakrishnan, Quentin Greba, Wendie N. Marks
Publikováno v:
Clinical and Experimental Pharmacology and Physiology. 47:1530-1536
Insulin-mediated signalling in the brain is critical for neuronal functioning. Insulin resistance is implicated in the development of some neurological diseases, although changes associated with absence epilepsy have not been established yet. Therefo
Publikováno v:
Behavioural Brain Research. 361:54-64
Abnormalities in social behavior are a co-morbid symptom of idiopathic generalized epilepsies such as childhood absence epilepsy. The Genetic Absence Epilepsy Rats from Strasbourg (GAERS) model is a spontaneously occurring absence epilepsy phenotype
Autor:
Nimra B. Tahir, John G. Howland, Quentin Greba, Wendie N. Marks, Yuanyi Song, Thaísa M. Sandini
Publikováno v:
Neuroscience. 440
Sensory integration (SI) is a cognitive process whereby the brain uses unimodal or multimodal sensory features to create a comprehensive representation of the environment. Integration of sensory input is necessary to achieve a coherent perception of
Publikováno v:
Neuroscience. 430
Absence Epilepsy (AE) is associated with recurrent losses of awareness and synchronous bilateral spike-wave discharges (SWDs). While seizures do not generally continue into adulthood, cognitive and behavioral comorbidities persist. One preclinical mo
Autor:
Terrance P. Snutch, Quentin Greba, Wendie N. Marks, Nadine K. Zabder, Madeline E. Parker, John G. Howland
Publikováno v:
Learning & Memory. 25:317-324
The roles of low-voltage-activated (T-type) calcium channels in brain diseases have been studied extensively. Less is known regarding the involvement of T-type channels in cognition and behavior. Sensory integration (SI) is a cognitive process whereb
Autor:
Robert B. Laprairie, Stuart M. Cain, Matthew N. Hill, Ganesh A. Thakur, Samantha L. Baglot, Terrance P. Snutch, John G. Howland, Sumanta Garai, Quentin Greba, Wendie N. Marks, Anna-Maria Smolyakova, Gavin N. Petrie, Andrew J. Roebuck, Mariam Alaverdashvili
Publikováno v:
Neuropharmacology. 190:108553
Childhood Absence Epilepsy (CAE) accounts for approximately 10% of all pediatric epilepsies. Current treatments for CAE are ineffective in approximately 1/3 of patients and can be associated with severe side effects such as hepatotoxicity. Certain ca
Publikováno v:
Psychopharmacology. 234:1079-1091
The search for novel antipsychotic drugs to treat schizophrenia is driven by the poor treatment efficacy, serious side effects, and poor patient compliance of current medications. Recently, a class of compounds known as tetrahydroprotoberberines, whi
Autor:
Don A. Davies, Jillian K. Catton, Jessica L. Hurtubise, Wendie N. Marks, John G. Howland, Glen B. Baker
Publikováno v:
Psychopharmacology. 234:211-222
The cognitive symptoms observed in schizophrenia are not consistently alleviated by conventional antipsychotics. Following a recent pilot study, sodium nitroprusside (SNP) has been identified as a promising adjunct treatment to reduce the working mem
Publikováno v:
Neurobiology of Disease, Vol 94, Iss, Pp 106-115 (2016)
Childhood absence epilepsy (CAE) is often comorbid with behavioral and cognitive symptoms, including impaired visual memory. Genetic Absence Epilepsy Rats from Strasbourg (GAERS) is an animal model closely resembling CAE; however, cognition in GAERS
Publikováno v:
Neuroscience. 332:121-129
The role of T-type calcium channels in brain diseases such as absence epilepsy and neuropathic pain has been studied extensively. However, less is known regarding the involvement of T-type channels in cognition and behavior. Prepulse inhibition (PPI)