Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Valentina Siino"'
Publikováno v:
Journal of Proteome Research. 20:4075-4088
Understanding the molecular basis of sexual dimorphism in the cardiovascular system may contribute to the improvement of the outcome in biological, pharmacological, and toxicological studies as well as on the development of sex-based drugs and therap
Autor:
Anders Moen, Jesper V. Olsen, Lisa Schroer, Ida A. Grønsberg, Niels Eijkelkamp, Albert Jeltsch, Takehiro Suzuki, Tadahiro Shimazu, Naoshi Dohmae, Erna Davydova, Mikiko Sodeoka, Valentina Siino, Mai Akakabe, Jędrzej Małecki, Pål Ø. Falnes, Michael A. McDonough, Takashi Umehara, Yoshihiro Sohtome, Magnus E. Jakobsson, Angela Ho, Rita Pinto, Masaki Kikuchi, Sara Weirich, Christopher J. Schofield, Yoichi Shinkai, Hanneke L.D.M. Willemen, Maren Kirstin Schuhmacher, Tongri Liu
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Davydova, E, Shimazu, T, Schuhmacher, M K, Jakobsson, M E, Willemen, H L D M, Liu, T, Moen, A, Ho, A Y Y, Małecki, J, Schroer, L, Pinto, R, Suzuki, T, Grønsberg, I A, Sohtome, Y, Akakabe, M, Weirich, S, Kikuchi, M, Olsen, J V, Dohmae, N, Umehara, T, Sodeoka, M, Siino, V, McDonough, M A, Eijkelkamp, N, Schofield, C J, Jeltsch, A, Shinkai, Y & Falnes, P 2021, ' The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes ', Nature Communications, vol. 12, 891 . https://doi.org/10.1038/s41467-020-20670-7
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Davydova, E, Shimazu, T, Schuhmacher, M K, Jakobsson, M E, Willemen, H L D M, Liu, T, Moen, A, Ho, A Y Y, Małecki, J, Schroer, L, Pinto, R, Suzuki, T, Grønsberg, I A, Sohtome, Y, Akakabe, M, Weirich, S, Kikuchi, M, Olsen, J V, Dohmae, N, Umehara, T, Sodeoka, M, Siino, V, McDonough, M A, Eijkelkamp, N, Schofield, C J, Jeltsch, A, Shinkai, Y & Falnes, P 2021, ' The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes ', Nature Communications, vol. 12, 891 . https://doi.org/10.1038/s41467-020-20670-7
Post-translational methylation plays a crucial role in regulating and optimizing protein function. Protein histidine methylation, occurring as the two isomers 1- and 3-methylhistidine (1MH and 3MH), was first reported five decades ago, but remains la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e8df554296bacb78fc88ad2f9d35057
https://ora.ox.ac.uk/objects/uuid:5d2edc4d-b490-4789-a8f9-e3a23c7392d4
https://ora.ox.ac.uk/objects/uuid:5d2edc4d-b490-4789-a8f9-e3a23c7392d4
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-19 (2021)
BMC Bioinformatics
BMC Bioinformatics
BackgroundVisual exploration of gene product behavior across multiple omic datasets can pinpoint technical limitations in data and reveal biological trends. Still, such exploration is challenging as there is a need for visualizations that are tailore
Autor:
P. Humblot, T. Hallap, Valentina Siino, Jane M. Morrell, Jakob Willforss, Dirk-Jan de Koning, Fredrik Levander, Erik Andreasson, P. Padrik, Svante Resjö
Publikováno v:
Journal of proteomics. 236
Bull fertility is an important trait in breeding as the semen of one bull can, potentially, be used to perform thousands of inseminations. The high number of inseminations needed to obtain reliable measures from Non-Return Rates to oestrus creates di
Autor:
Prasannakumar Deshpande, Laura L. Elo, Valentina Siino, Lihua Sun, Peter James, Valtteri Kaasinen, Elena Goltseva, Eleanor T. Coffey, Ye Hong, Sirkku Peltonen, Dani Flinkman
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 34(11)
Gain of function LRRK2-G2019S is the most frequent mutation found in familial and sporadic Parkinson's disease. It is expected therefore that understanding the cellular function of LRRK2 will provide insight on the pathological mechanism not only of
Autor:
Calogero Caruso, Giulia Accardi, Valentina Siino, Giuseppina Candore, Patrizia Cancemi, Francesca Di Gaudio, Laura Cristaldi, Sonya Vasto, Anna Aiello, Marcello Ciaccio, Rosalia Caldarella
Publikováno v:
Mediators of Inflammation
Mediators of Inflammation, Vol 2020 (2020)
Mediators of Inflammation, Vol 2020 (2020)
Extracellular matrix metalloproteinases (MMPs) are a group of proteins that activate substrates by enzymatic cleavage and, on the basis of their activities, have been demonstrated to play a role in ageing. Thus, in order to gain insight into the path
Autor:
Gaetano Felice Caldara, Antonella Amato, Francesca Di Salvo, Sonya Vasto, Marcello Filogamo, Valentina Siino, Peter James
Publikováno v:
The Journal of Nutritional Biochemistry. 58:102-109
Obesity is closely associated to several diseases such as type 2 diabetes, cardiovascular disease, hepatic steatosis, airway disease, neurodegeneration, biliary diseases and certain cancers. It is, therefore, of importance to assess the role of nutri
Autor:
Valentina Siino, Tuula Kallunki, Klaus Hansen, Malene Hansen, Knut Kristoffer Bundgaard Clemmensen, Ditte Marie Brix, José M.A. Moreira, Tiina Öhman, Marja Jäättelä, Irina Gromova, Peter James, Matteo Lambrughi, Elena Papaleo, Siri Amanda Tvingsholm, Pietri Puustinen, Markku Varjosalo
HER2/ErbB2 activation turns on transcriptional processes that induce local invasion and lead to systemic metastasis. The early transcriptional changes needed for ErbB2-induced invasion are poorly understood. Here, we link ErbB2 activation to invasion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb05c35f7590096ea31b0a481d0c32d4
https://europepmc.org/articles/PMC6525100/
https://europepmc.org/articles/PMC6525100/
Autor:
Martin R. Larsen, Giulia Accardi, Pia Jensen, Peter James, Antonella Amato, Flavia Mulè, Valentina Siino, Sonya Vasto
Publikováno v:
Nutrition and Metabolic Insights
Nutrition and Metabolic Insights, Vol 14 (2021)
Nutrition and Metabolic Insights, Vol 14 (2021)
Obesity constitutes a major global health threat and is associated with a variety of diseases ranging from metabolic and cardiovascular disease, cancer to neurodegeneration. The hallmarks of neurodegeneration include oxidative stress, proteasome impa
Autor:
Valentina Siino, Fredrik Levander, Ramin Massoumi, Katarzyna Chmielarska Masoumi, Renée Daams, Hengning Ke, Wondossen Sime
Publikováno v:
Molecular Biology of the Cell
Primary embryonic fibroblast cells isolated from NLK-deficient mice proliferate faster and have a shorter cell cycle than wild-type cells. Nemo-like kinase and HDAC1 together negatively regulate Wnt signaling via Tcf/Lef transcription repression and