Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Timothy J. Mitchison"'
Autor:
Timothy J. Mitchison
Publikováno v:
Molecular Biology of the Cell
Macromolecule condensates, phase separation, and membraneless compartments have become an important area of cell biology research where new biophysical concepts are emerging. This article discusses the possibility that condensates assemble on multiva
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
Individual cancers rely on distinct essential genes for their survival. The Cancer Dependency Map (DepMap) is an ongoing project to uncover these gene dependencies in hundreds of cancer cell lines. To make this drug discovery resource more accessible
Autor:
Timothy J. Mitchison
Publikováno v:
Curr Biol
Cellular organelles such as the mitotic spindle adjust their size to the dimensions of the cell. It is widely understood that spindle scaling is governed by regulation of microtubule polymerization. Here, we use quantitative microscopy in living zebr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54b11db999a59b9b54d4dca7128ffd7f
https://europepmc.org/articles/PMC8108444/
https://europepmc.org/articles/PMC8108444/
Autor:
Timothy J. Mitchison, Tae Yeon Yoo
Publikováno v:
The Journal of Cell Biology
Kohler highlights work from Yoo and Mitchison that reveals that O-GlcNAcylation of the nuclear pore complex accelerates nucleocytoplasmic trafficking in both directions.
FG-repeat nucleoporins at the center of the nuclear pore complex (NPC) are
FG-repeat nucleoporins at the center of the nuclear pore complex (NPC) are
Autor:
Douglas A. Lauffenburger, Stephanie W. Wang, Timothy J. Mitchison, Gaurav Luthria, Rainer H. Kohler, Mark Prytyskach, Miles A. Miller, Ran Li, Ralph Weissleder
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Microtubules (MTs) mediate mitosis, directional signaling, and are therapeutic targets in cancer. Yet in vivo analysis of cancer cell MT behavior within the tumor microenvironment remains challenging. Here we developed an imaging pipeline using plus-
Autor:
J Christine Yuan, Joann Kalabathula, Timothy J. Mitchison, Brian J. Groendyke, Ivana Gasic, Nathanael S. Gray, Radosław P. Nowak, Eric S. Fischer
Publikováno v:
Cells, Vol 9, Iss 1083, p 1083 (2020)
Cells
Volume 9
Issue 5
Cells
Volume 9
Issue 5
Dysregulation of microtubules and tubulin homeostasis has been linked to developmental disorders, neurodegenerative diseases, and cancer. In general, both microtubule-stabilizing and destabilizing agents have been powerful tools for studies of microt
SummaryIndividual cancers rely on distinct essential genes for their survival. The Cancer Dependency Map (DepMap) is an ongoing project to uncover gene dependency in hundreds of cancer cell lines. DepMap is a powerful drug discovery tool, but can be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2250ad8af443e8046f092b4a60402d6
Autor:
Timothy J. Mitchison, Al Charest, Keith L. Ligon, Ennio Antonio Chiocca, Aron Gyuris, Alan T. Yeo, Franziska Michor, Jann N. Sarkaria, Ichiro Nakano, Hua-Jun Wu, Agnieszka Bronisz, Steve P. Gygi, Roderick T. Bronson, Bethany Delcuze, Charlotte E. Lee, Steve Woolfenden, Javier Pineda, Hyun Jung Jun, Christopher M. Rose, Haihao Zhu, Vicky A. Appleman
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nature Communications
Nature Communications
Glioblastoma multiforme (GBM) is an aggressive primary brain cancer that includes focal amplification of PDGFRα and for which there are no effective therapies. Herein, we report the development of a genetically engineered mouse model of GBM based on
Publikováno v:
Curr Biol
The microtubule cytoskeleton plays critically important roles in numerous cellular functions in eukaryotes, and it does so across a functionally diverse and morphologically disparate range of cell types [1]. In these roles, microtubule assemblies mus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afdc189931f9fbaa98f222fef7f87736
https://doi.org/10.1101/849190
https://doi.org/10.1101/849190
Autor:
Ivana Gasic, Viswanathan Chandrasekaran, Sichen Shao, Ramanujan S. Hegde, Zhewang Lin, Timothy J. Mitchison, Niklas Peters
Publikováno v:
Science
Cell Res
Cell Res
Mechanism of tubulin autoregulation Cells tightly control the abundance of key housekeeping factors, such as ribosomes and chaperones, to maintain them at optimal levels needed for homeostasis. Most abundance control mechanisms involve feedback regul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a695974e6ab42103d76764e72e7fde43
https://europepmc.org/articles/PMC6942541/
https://europepmc.org/articles/PMC6942541/