Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Thomas Lehner"'
Autor:
Susan E. Koester, Susan Borja, Linda S. Brady, Tara Dutka, Thomas Lehner, Kathleen R. Merikangas, Anjené M. Addington, P. Alexander Arguello, Miri Gitik, Geetha Senthil, David M. Panchision, Francis J. McMahon, Douglas L. Meinecke
Publikováno v:
Molecular Psychiatry. 24:1576-1582
The Genomics Workgroup of the National Advisory Mental Health Council (NAMHC) recently issued a set of recommendations for advancing the NIMH psychiatric genetics research program and prioritizing subsequent follow-up studies. The report emphasized t
Autor:
Jonathan Warrell, Stamatios N. Sotiropoulos, Michael J. Gandal, Geetha Senthil, Justin T. Baker, Stefan Bekiranov, Jacob M. Taylor, Alán Aspuru-Guzik, Thomas Lehner, Matteo Bastiani, Aram W. Harrow, John D. Murray, Michael J. McConnell, Alan Anticevic, Prashant Emani, Guillermo Sapiro, Mark Gerstein
Publikováno v:
Nat Methods
The search for meaningful structure in biological data has relied on cutting-edge advances in computational technology and data science methods. However, challenges arise as we push the limits of scale and complexity in biological problems. Innovatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8e6b894abf5f9be5f976cfcf66f8701
http://arxiv.org/abs/1911.07127
http://arxiv.org/abs/1911.07127
Autor:
Amanda Dobbyn, Laura M. Huckins, James Boocock, Laura G. Sloofman, Benjamin S. Glicksberg, Claudia Giambartolomei, Gabriel E. Hoffman, Thanneer M. Perumal, Kiran Girdhar, Yan Jiang, Towfique Raj, Douglas M. Ruderfer, Robin S. Kramer, Dalila Pinto, Schahram Akbarian, Panos Roussos, Enrico Domenici, Bernie Devlin, Pamela Sklar, Eli A. Stahl, Solveig K. Sieberts, Joseph Buxbaum, David Lewis, Raquel Gur, Chang-Gyu Hahn, Keisuke Hirai, Hiroyoshi Toyoshiba, Laurent Essioux, Lara Mangravite, Mette Peters, Thomas Lehner, Barbara Lipska, A. Ercument Cicek, Cong Lu, Kathryn Roeder, Lu Xie, Konrad Talbot, Scott E. Hemby, Andrew Browne, Andrew Chess, Aaron Topol, Alexander Charney, Ben Readhead, Bin Zhang, David A. Bennett, David H. Kavanagh, Eric E. Schadt, Hardik R. Shah, Jun Zhu, Jessica S. Johnson, John F. Fullard, Joel T. Dudley, Kristen J. Brennand, Menachem Fromer, Milind C. Mahajan, Shaun M. Purcell, Tymor Hamamsy, Vahram Haroutunian, Ying-Chih Wang, Zeynep H. Gümüş, Geetha Senthil, Robin Kramer, Benjamin A. Logsdon, Jonathan M.J. Derry, Kristen K. Dang, Roberto Visintainer, Leslie A. Shinobu, Patrick F. Sullivan, Lambertus L. Klei
Publikováno v:
American Journal of Human Genetics
Causal genes and variants within genome-wide association study (GWAS) loci can be identified by integrating GWAS statistics with expression quantitative trait loci (eQTL) and determining which variants underlie both GWAS and eQTL signals. Most analys
Autor:
Robert E. Handsaker, Donna M. Werling, A. Jeremy Willsey, Chiara Sabatti, Kevin Eggan, Raquel E. Gur, Anjené M. Addington, P. Alexander Arguello, Aarno Palotie, John Blangero, Matthew W. State, Mark J. Daly, Joon Yong An, Nelson B. Freimer, Roel A. Ophoff, Daniel H. Geschwind, Michael Boehnke, David C. Glahn, Steven E. Hyman, Benjamin M. Neale, Thomas Lehner, Hailiang Huang, Carlos N. Pato, David Goldstein, Stephen Sanders, Shan Dong, Gonçalo R. Abecasis, Steven A. McCarroll
Publikováno v:
Nat Neurosci
As technology advances, whole genome sequencing (WGS) is likely to supersede other genotyping technologies. The rate of this change depends on its relative cost and utility. Variants identified uniquely through WGS may reveal novel biological pathway
Publikováno v:
Cell. 171:261-264
The genetics of African populations reveals an otherwise "missing layer" of human variation that arose between 100,000 and 5 million years ago. Both the vast number of these ancient variants and the selective pressures they survived yield insights in
Publikováno v:
Molecular Psychiatry. 22:1659-1663
The National Institute of Mental Health (NIMH) has made sustained investments in the development of genomic resources over the last two decades. These investments have led to the development of the largest biorepository for psychiatric genetics as a
Autor:
Thomas Lehner, Geetha Senthil
Publikováno v:
Schizophrenia research. 217
The last decade has provided new insights into the genetic architecture of schizophrenia. For the first time researchers have identified genetic factors conferring risk that can be mapped to tissue and cell specific perturbations of the molecular mac
Autor:
Meera E. Modi, Stephen Sanders, Guoping Feng, Paul Avillach, Carrie E. Bearden, Anne Pariser, Thomas Lehner, Andres Moreno-De-Luca, Audrey Thurm, David H. Ledbetter, Raquel E. Gur, Elise Douard, Jonathan Sebat, Joseph Hostyk, Ricardo E. Dolmetsch, David B. Goldstein, Daniel H. Geschwind, Christa Lese Martin, David C. Glahn, Sébastien Jacquemont, Armin Raznahan, Mustafa Sahin, Rodney C. Samaco, Alan Anticevic, Jennifer G. Mulle, Sergiu P. Paşca
Publikováno v:
Nat Med
other univ website
Nature medicine, vol 25, iss 10
other univ website
Nature medicine, vol 25, iss 10
De novo and inherited rare genetic disorders (RGDs) are a major cause of human morbidity, frequently involving neuropsychiatric symptoms. Recent advances in genomic technologies and data sharing have revolutionized the identification and diagnosis of
Autor:
Gary S. Gray, Adam Savitz, John W. Jackson, Jake Spertus, Thomas Lehner, Geetha Senthil, Linda Valeri, Hardeep Ranu, Marsha A. Wilcox, Sharon-Lise T. Normand, Anjené M. Addington, Eva C. Guinan, Joseph S. Ross
Publikováno v:
NPJ Schizophrenia
npj Schizophrenia, Vol 4, Iss 1, Pp 1-3 (2018)
npj Schizophrenia, Vol 4, Iss 1, Pp 1-3 (2018)
Clinical trial data are the gold standard for evaluating pharmaceutical safety and efficacy. There is an ethical and scientific imperative for transparency and data sharing to confirm published results and generate new knowledge. The Open Translation
Autor:
Christine Stevens, Michael E. Zwick, Deepthi Rajagopalan, Mara Parellada, David J. Cutler, Li-San Wang, Norio Ozaki, Jinlu Cai, Lauren A. Weiss, Patricia Jiménez González, Jeffrey C. Barrett, Silvia De Rubeis, Helena Kilpinen, Alexander Kolevzon, Timothy W. Yu, Michael John Owen, Geraldine Dawson, Martin Schulte-Rüther, Jeremy R. Parr, Aarno Palotie, Eftichia Duketis, Lambertus Klei, Irene Lee, Bridget A. Fernandez, Aniko Sabo, Matthew W. State, Sarah Curran, Lucy Crooks, Chad M. Schafer, Avi Ma'ayan, Stephen Sanders, Evan T. Geller, Monica Biscaldi, Stephen W. Scherer, Christopher S. Poultney, Mark J. Daly, Patrick Bolton, Kaija Puura, Maria H. Chahrour, Michael Gill, Li Liu, Louise Gallagher, Ryan K. C. Yuen, Jack A. Kosmicki, Abraham Reichenberg, Christine M. Freitag, Shaun Purcell, Andreas G. Chiocchetti, Peter Szatmari, Sabine M. Klauck, Shih-Chen Fu, Christian R. Marshall, Joseph D. Buxbaum, Tarjinder Singh, Bernie Devlin, Chiao-Feng Lin, A. Ercument Cicek, Karola Rehnström, Pamela Sklar, Otto Valladares, Michael Sachse, Terho Lehtimäki, R. Sean Hill, Arthur P. Goldberg, A. Jeremy Willsey, Jing Lei, Branko Aleksic, Menachem Fromer, Yan Kou, Jessica M. Brownfeld, Annette Voran, Kathryn Roeder, Gerard D. Schellenberg, David Skuse, Thomas Lehner, Hilary Coon, Benjamin M. Neale, Iuliana Ionita-Laza, Kristiina Tammimies, Stephen J. Guter, Christopher A. Walsh, James S. Sutcliffe, Xin-Xin He, Alison L. McInnes, Emily L. Crawford, Nicholas G. Campbell, Angel Carracedo, R. Susan Walker, Edwin H. Cook, Kaitlin E. Samocha, Christina M. Hultman
Publikováno v:
Nature
The genetic architecture of autism spectrum disorder involves the interplay of common and rare variants and their impact on hundreds of genes. Using exome sequencing, here we show that analysis of rare coding variation in 3,871 autism cases and 9,937