Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Richard A, Koup"'
Autor:
Katherine V. Houser, Edmund V. Capparelli, John R. Mascola, Britta Flach, Adrian B. McDermott, Barney S. Graham, Emily E. Coates, Richard A. Koup, Mina Nikanjam, Lucio Gama, Jerry Li, Coleen K. Cunningham, Elizabeth J. McFarland, Bob C. Lin, Julie E. Ledgerwood
Publikováno v:
Clin Pharmacol Ther
VRC01 is a first-in-class, potent, broadly neutralizing antibody that targets the CD4 binding site of gp120 on HIV-1 viruses, and is under development as a novel HIV therapeutic. This study utilized population pharmacokinetic modeling to characterize
Autor:
Eirini Moysi, Perla M. Del Rio Estrada, Fernanda Torres-Ruiz, Gustavo Reyes-Terán, Richard A. Koup, Constantinos Petrovas
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, Vol 12 (2021)
CD4 T cells are key mediators of adaptive immune responses during infection and vaccination. Within secondary lymphoid organs, helper CD4 T cells, particularly those residing in germinal centers known as follicular helper T cells (Tfh), provide criti
Autor:
Constantinos Petrovas, Giulia Fabozzi, Rafick-Pierre Sekaly, Alessandra Noto, Maria Maddalena Perra, Craig Fenwick, Giuseppe Pantaleo, Sanjana Shah, Alexander Chassiakos, Vasilis Papaioannou, Richard A. Koup, Daniel C. Douek, Kartika Padhan, David R. Ambrozak, Khader Ghneim, Eirini Moysi, Antigoni Poultsidi, Samuel Darko, Maria Ioannou
Publikováno v:
Proc Natl Acad Sci U S A
The development of follicular helper CD4 T (TFH) cells is a dynamic process resulting in a heterogenous pool of TFH subsets. However, the cellular and molecular determinants of this heterogeneity and the possible mechanistic links between them is not
Autor:
Nicole A. Doria-Rose, Cheng Cheng, Tyler Stephens, Shuishu Wang, Steven J. Chen, Peter D. Kwong, John Paul Todd, Christopher A. Gonelli, Amarendra Pegu, Sijy O'Dell, Richard A. Koup, Vrc Production Program, Kai Xu, Baoshan Zhang, John R. Mascola, Adrian B. McDermott, Hongying Duan, Jelle van Schooten, Li Ou, Jeffrey C. Boyington, Manjula Basappa, Angela R. Corrigan, Sarah O’Connell, Sandeep Narpala, Kathryn E. Foulds, Megan E. DeMouth, Marit J. van Gils, Yaroslav Tsybovsky, Tongqing Zhou, Hui Geng
Publikováno v:
Cell reports, 35(1):108937. Cell Press
Cell Reports, Vol 35, Iss 1, Pp 108937-(2021)
Cell reports
Cell Reports, Vol 35, Iss 1, Pp 108937-(2021)
Cell reports
SUMMARY Soluble “SOSIP”-stabilized envelope (Env) trimers are promising HIV-vaccine immunogens. However, they induce high-titer responses against the glycan-free trimer base, which is occluded on native virions. To delineate the effect on base re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c25456efa28d5031ea6efc66dceedf09
https://pure.amc.nl/en/publications/fusion-peptide-priming-reduces-immune-responses-to-hiv1-envelope-trimer-base(8874d9ca-be54-4482-9c96-b1171a7bdf93).html
https://pure.amc.nl/en/publications/fusion-peptide-priming-reduces-immune-responses-to-hiv1-envelope-trimer-base(8874d9ca-be54-4482-9c96-b1171a7bdf93).html
Autor:
Michael Chambers, Safiatou Doumbo, Sarah F. Andrews, Peter D. Crompton, Peter D. Sun, Eric O. Long, Shanping Li, Mary E. Peterson, Richard A. Koup, Boubacar Traore, Kristin L. Boswell, Adrian B. McDermott, Joshua Tan, Aissata Ongoiba, Kassoum Kayentao, Jinghua Lu, Kazutoyo Miura, Christopher M. Tipton, Ababacar Diouf, Carole A. Long, Padmapriya Sekar, Christine S. Hopp, Silvia Portugal, Jeff Skinner
Publikováno v:
The Journal of Experimental Medicine
The role of IgM in human malaria is unclear. In a cohort study in Mali, Hopp et al. find that malaria-specific memory B cells are disproportionally IgM in children, are activated during acute malaria, and produce IgM that inhibits malaria parasite gr
Publikováno v:
Methods. 154:118-124
Bispecific (bs) antibodies (Abs, bsAbs) are engineered immunoglobulins that contain two different antigen-binding sites in one molecule. bsAbs can be divided in two molecular formats; the IgG-like and non-IgG like. The structural elements of each for
Publikováno v:
Retrovirology, Vol 15, Iss 1, Pp 1-10 (2018)
Retrovirology
Retrovirology
The induction of HIV-1-specific antibodies that can neutralize a broad number of isolates is a major goal of HIV-1 vaccination strategies. However, to date no candidate HIV-1 vaccine has successfully elicited broadly neutralizing antibodies of suffic
Autor:
Richard A. Koup, Michel C. Nussenzweig, Yoshiaki Nishimura, Reza Sadjadpour, Sara Ferrando-Martinez, Malcolm A. Martin, Romas Geleziunas, Alicia Buckler-White, Rajeev Gautam, Olivia K. Donau, Eric Jesteadt, Joana Dias
Publikováno v:
The Journal of Experimental Medicine
Macaque recipients of anti–HIV-1 combination NAb treatment starting on PI day 3 or week 2 generate CD8+ cellular immunity that maintains durable suppression of SHIV replication and circulating CD4+ T cell levels during a 3–6-yr observation period
Autor:
Laura L. Sutherland, Takuya Yamamoto, Barton F. Haynes, Norman L. Letvin, Madhu Prabhakaran, Wesley Hoyland, Sandeep Narpala, David J. Pickup, Steven Ma, Christopher Fletez-Brant, Mario Roederer, Sampa Santra, Adrian B. McDermott, Hua-Xin Liao, Richard A. Koup, Michelle L. Lifton, Elizabeth Ramsburg, Kristin L. Boswell, Gail Levine, Constantinos Petrovas, Leila Eslamizar, David J. Leggat, Kathryn Furr, David C. Montefiori
Publikováno v:
NPJ Vaccines
npj Vaccines, Vol 6, Iss 1, Pp 1-10 (2021)
npj Vaccines, Vol 6, Iss 1, Pp 1-10 (2021)
The RV144 HIV-1 vaccine trial has been the only clinical trial to date that has shown any degree of efficacy and associated with the presence of vaccine-elicited HIV-1 envelope-specific binding antibody and CD4+ T-cell responses. This trial also show
Autor:
Rachel L. Rutishauser, Peter W. Hunt, Kyle A. Raymond, Daniel C. Douek, Theodore L. Roth, Rafick-Pierre Sekaly, Frederick Hecht, Alexander Marson, Carly E. Starke, Franziska Blaeschke, Steven G. Deeks, Christian Deo T Deguit, Christopher D. Pilcher, Joseph Hiatt, Joseph C. Mudd, Wenxuan Chen, Carolyn P Smullin, Joseph M. McCune, Satish K. Pillai, Melissa R. Krone, Richard A. Koup, Rebecca Hoh, Jeffrey N. Martin, Jason M. Brenchley, Lynn Wang, Rodrigo Matus-Nicodemos
Publikováno v:
JCI Insight
JCI Insight, Vol 6, Iss 3 (2021)
JCI insight, vol 6, iss 3
JCI Insight, Vol 6, Iss 3 (2021)
JCI insight, vol 6, iss 3
Although many HIV cure strategies seek to expand HIV-specific CD8+ T cells to control the virus, all are likely to fail if cellular exhaustion is not prevented. A loss in stem-like memory properties (i.e., the ability to proliferate and generate seco