Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Neeraj Kumar Singh"'
Autor:
Shireen Vali, Sumanth Vasista, Joel W. Neal, Taher Abbasi, Jacqueline V. Aredo, Neeraj Kumar Singh, Heather A. Wakelee, Sukhmani K. Padda, Ansu Kumar
Publikováno v:
JCO Precision Oncology. :153-162
PURPOSE KRAS-mutated ( KRASMUT) non–small-cell lung cancer (NSCLC) is emerging as a heterogeneous disease defined by comutations, which may confer differential benefit to PD-(L)1 immunotherapy. In this study, we leveraged computational biological m
Publikováno v:
Molecular Psychiatry
BACE1 initiates production of β-amyloid peptides (Aβ), which is associated with cognitive dysfunction in Alzheimer’s disease (AD) due to abnormal oligomerization and aggregation. While BACE1 inhibitors show strong reduction in Aβ deposition, the
Autor:
Sunil Badve, Sumanth Vasista, Sukhmani K. Padda, Heather A. Wakelee, Jessica A. Hellyer, Kabya Basu, Yesim Gökmen-Polar, Neeraj Kumar Singh, Ansu Kumar
Publikováno v:
Oncotarget
Further characterization of thymic epithelial tumors (TETs) is needed. Genomic information from 102 evaluable TETs from The Cancer Genome Atlas (TCGA) dataset and from the IU-TAB-1 cell line (type AB thymoma) underwent clustering analysis to identify
Publikováno v:
Ophthalmic and Physiological Optics. 40:549-556
PURPOSE High sampling density optical metrology combined with pupil- and image-plane numerical analyses were applied to evaluate a novel spectacle lens containing multiple small zones designed to slow myopia progression. METHODS High-resolution aberr
Autor:
Dawn Meyer, Martin E. Rickert, Arthur Bradley, Viswanathan Ramasubramanian, Olivia Reed, Neeraj Kumar Singh, Matt Jaskulski, Pete S Kollbaum
Publikováno v:
Optometry and Vision Science. 96:733-744
Significance Measurement of ocular aberrations is a critical component of many optical corrections. Purpose This study examines the accuracy and repeatability of a newly available high-resolution pyramidal wavefront sensor-based aberrometer (Osiris b
Autor:
John Hardy, Riqiang Yan, Akihiko Koyama, Harald Hampel, Lisa Yarenis, Andrea Vergallo, Robert Nisticò, Simone Lista, Johannes Streffer, Michael C. Irizarry, Iryna Voytyuk, Massimo Corbo, Maarten Timmers, Michael Willem, Amir Abbas Tahami Monfared, Bart De Strooper, John Zhou, Bruce Albala, Ann De Vos, Bruno P. Imbimbo, Teiji Kimura, Robert Vassar, Neeraj Kumar Singh, Eugeen Vanmechelen, Lynn D. Kramer, Naoto Watanabe
Publikováno v:
Biological Psychiatry
Biological Psychiatry, Elsevier, 2021, 89 (8), pp.745-756. ⟨10.1016/j.biopsych.2020.02.001⟩
Biol Psychiatry
Biological psychiatry
Biological Psychiatry, Elsevier, 2021, 89 (8), pp.745-756. ⟨10.1016/j.biopsych.2020.02.001⟩
Biol Psychiatry
Biological psychiatry
BACE1 (beta-site amyloid precursor protein cleaving enzyme 1) was initially cloned and characterized in 1999. It is required for the generation of all monomeric forms of amyloid-β (Aβ), including Aβ42, which aggregates into bioactive conformationa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3fca01ac69e9a8f23ac42d1296010c0
https://hal.sorbonne-universite.fr/hal-03197728
https://hal.sorbonne-universite.fr/hal-03197728
Autor:
Fan Gao, Neeraj Kumar Singh, Qingyuan Fan, Manoshi Gayen, Riqiang Yan, Wanxia He, Xiangyou Hu, Li-Huei Tsai
Publikováno v:
The Journal of Experimental Medicine
Journal of Experimental Medicine (JEM)
Journal of Experimental Medicine (JEM)
The membrane-anchored CX3CL1 is best known to exert its signaling function through binding its receptor CX3CR1. This study demonstrates a novel function that CX3CL1 exerts. CX3CL1 is sequentially cleaved by α-, β-, and γ-secretase, and the release
Autor:
Shireen Vali, Christopher R. Cogle, Jan S. Moreb, Glenda G. Anderson, Vindhya Vijay, Neeraj Kumar Singh, John W. Hiemenz, Jatinder K. Lamba, Cesia Salan, Jack W. Hsu, Arati Khanna-Gupta, William B. Slayton, Kimberly E. Hawkins, Elizabeth Wise, Amy Meacham, Nosha Farhadfar, Christina Cline, Paul Castillo, Biljana Horn, Leylah Drusbosky, Taher Abbasi, Maxim Norkin, S. Radhakrishnan, Helen Leather, Caitlin Tucker, Yashaswini S Ullal, Madeleine Turcotte, Huzaifa Sikora, Prashant Ramachandran Nair, Leslie Pettiford, John R. Wingard, Hemant S. Murthy, Subharup Guha, Charlie C. Kim, Randy A. Brown, Anay Talawdekar
Publikováno v:
Blood Advances. 3:1837-1847
Patients with myelodysplastic syndromes (MDS) or acute myeloid leukemia (AML) are generally older and have more comorbidities. Therefore, identifying personalized treatment options for each patient early and accurately is essential. To address this,
Autor:
Shireen Vali, Diana Abbott, Andrew Hammes, Derek Schatz, Gregory Hemenway, Neeraj Kumar Singh, Clayton A. Smith, Taher Abbasi, Brett M. Stevens, Jonathan A. Gutman, Daniel A. Pollyea, Craig T. Jordan, Christopher R. Cogle, Aaron Fullerton, Amanda Winters, Nicholas Miltgen, Qi Wei, Leylah Drusbosky
Publikováno v:
Leukemia Research. 81:43-49
Background Patients with relapsed and refractory (R/R) acute myeloid leukemia (AML) have limited treatment options. Genomically-defined personalized therapies are only applicable for a minority of patients. Therapies without identifiable targets can
Autor:
Vivek Lawana, Neeraj Kumar Singh, Bharathi N. Palanisamy, Dharmin Rokad, Ahmed Abdalla, Jie Luo, Huajun Jin, Vellareddy Anantharam, Arthi Kanthasamy, Souvarish Sarkar, Phang Phong, Anumantha G. Kanthasamy
Publikováno v:
Neurobiology of Disease, Vol 117, Iss, Pp 82-113 (2018)
The organophosphate (OP) pesticide chlorpyrifos (CPF), used in agricultural settings, induces developmental and neurological impairments. Recent studies using in vitro cell culture models have reported CPF exposure to have a positive association with