Zobrazeno 1 - 6
of 6
pro vyhledávání: '"N. Keenan"'
Autor:
Magdalene K. Montgomery, Stacey N Keenan, David A Wattchow, Damien J. Keating, Emily W. Sun, Matthew J. Watt, Hamzeh Karimkhanloo
Publikováno v:
Journal of Endocrinology. 248:167-179
Cathepsin S (CTSS) is a cysteine protease that regulates many physiological processes and is increased in obesity and type 2 diabetes. While previous studies show that deletion of CTSS improves glycaemic control through suppression of hepatic glucose
Autor:
Matthew J. Watt, Jennifer Chi Yi Lo, Ruth C. R. Meex, Magdalene K. Montgomery, Stacey N Keenan, Andrew Ryan, Shuai Nie
Publikováno v:
Diabetes, 68(3), 543-555. American Diabetes Association
Defects in hepatic lipid metabolism cause nonalcoholic fatty liver disease and insulin resistance, and these pathologies are closely linked. Regulation of lipid droplet metabolism is central to the control of intracellular fatty acid fluxes, and peri
Autor:
James G. Granneman, Stacey N Keenan, Jieqiong Lou, Ralf B. Schittenhelm, Magdalene K. Montgomery, William De Nardo, Matthew J. Watt, Elizabeth Hinde
Publikováno v:
Journal of Lipid Research
Journal of Lipid Research, Vol 62, Iss, Pp 100016-(2021)
Journal of Lipid Research, Vol 62, Iss, Pp 100016-(2021)
Perilipin 5 (PLIN5) is a lipid-droplet-associated protein that coordinates intracellular lipolysis in highly oxidative tissues and is thought to regulate lipid metabolism in response to phosphorylation by protein kinase A (PKA). We sought to identify
Autor:
Renea A. Taylor, Paul Burton, Matthew J. Watt, Thomas Tsiloulis, Stacey N Keenan, Geraldine J. Ooi, Arthe Raajendiran
Publikováno v:
American journal of physiology. Endocrinology and metabolism. 319(3)
Regional distribution of adipose tissue is an important factor in conferring cardiometabolic risk and obesity-related morbidity. We tested the hypothesis that human visceral adipose tissue (VAT) impairs glucose homeostasis, whereas subcutaneous glute
Publikováno v:
Current Diabetes Reports. 20
Impairments in mitochondrial function in patients with insulin resistance and type 2 diabetes have been disputed for decades. This review aims to briefly summarize the current knowledge on mitochondrial dysfunction in metabolic tissues and to particu
Autor:
Magdalene K. Montgomery, Jacqueline Bayliss, Stephen B. Ting, Matthew J. Watt, Stacey N Keenan, Sarah Rhost
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 33(12)
Adipose tissue plays a major role in the regulation of systemic metabolic homeostasis, with the AP2 adaptor complex being important in clathrin-mediated endocytosis (CME) of various cell surface receptors, including glucose transporter 4, the insulin