Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Michael P. Meers"'
Autor:
Carrie Myers, Steven J. Wu, Michael P. Meers, James M. Olson, Derek H. Janssens, Kami Ahmad, Steven Henikoff, Jay F. Sarthy
Publikováno v:
Epigenetics & Chromatin, Vol 11, Iss 1, Pp 1-14 (2018)
Epigenetics & Chromatin
Epigenetics & Chromatin
Background Our understanding of eukaryotic gene regulation is limited by the complexity of protein–DNA interactions that comprise the chromatin landscape and by inefficient methods for characterizing these interactions. We recently introduced CUT&R
Autor:
Nicholas A Vitanza, Jay F. Sarthy, Christina M. Lockwood, Steven Henikoff, Patrick J. Paddison, Michael P. Meers, James M. Olson, Kami Ahmad, Heather Feldman, Derek H. Janssens, Jorja G. Henikoff
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
Lysine 27-to-methionine (K27M) mutations in the H3.1 or H3.3 histone genes are characteristic of pediatric diffuse midline gliomas (DMGs). These oncohistone mutations dominantly inhibit histone H3K27 trimethylation and silencing, but it is unknown ho
Autor:
Heather L. Mulder, Peter Vogel, Steven Henikoff, Marcin Kamiński, Richard K. Wilson, Jinghui Zhang, Anang A. Shelat, James R. Downing, Marc Valentine, Yanling Liu, Xin Zhou, Yiping Fan, Armita Bahrami, Arlene Naranjo, Collin Van Ryn, Rani E. George, Sara M. Federico, Beisi Xu, Jongrye Jeon, Seungjae Lee, Xiang Chen, Elizabeth Stewart, John Easton, Donald Yergeau, Shondra M. Pruett-Miller, Jay F. Sarthy, Michael P. Meers, Maged Zeineldin, Michael A. Dyer, Lyra Griffiths, Michael R. Clay, Jackie L. Norrie, Elaine R. Mardis, Rosa Nguyen, Alberto S. Pappo, Michael D. Hogarty, Jianrong Wu
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Aggressive cancers often have activating mutations in growth-controlling oncogenes and inactivating mutations in tumor-suppressor genes. In neuroblastoma, amplification of the MYCN oncogene and inactivation of the ATRX tumor-suppressor gene correlate
Publikováno v:
Epigenetics & Chromatin
Epigenetics & Chromatin, Vol 12, Iss 1, Pp 1-11 (2019)
Epigenetics & Chromatin, Vol 12, Iss 1, Pp 1-11 (2019)
Background CUT&RUN is an efficient epigenome profiling method that identifies sites of DNA binding protein enrichment genome-wide with high signal to noise and low sequencing requirements. Currently, the analysis of CUT&RUN data is complicated by its
Publikováno v:
Mol Cell
Summary Although the in vitro structural and in vivo spatial characteristics of transcription factor (TF) binding are well defined, TF interactions with chromatin and other companion TFs during development are poorly understood. To analyze such inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc8e071527fd0a1d8bb3937b33601348
https://europepmc.org/articles/PMC6697550/
https://europepmc.org/articles/PMC6697550/
Publikováno v:
eLife
eLife, Vol 8 (2019)
eLife, Vol 8 (2019)
Previously, we described a novel alternative to chromatin immunoprecipitation, CUT&RUN, in which unfixed permeabilized cells are incubated with antibody, followed by binding of a protein A-Micrococcal Nuclease (pA/MNase) fusion protein (Skene and Hen
Autor:
Robert J. Duronio, Taylor J.R. Penke, A. Gregory Matera, Mary Leatham-Jensen, Michael P. Meers, Daniel J. McKay
Publikováno v:
Methods in Molecular Biology ISBN: 9781493986620
Histone post-translational modifications (PTMs) are thought to participate in a range of essential molecular and cellular processes, including gene expression, replication, and nuclear organization. Importantly, histone PTMs are also thought to be pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f52f8f5fb78a198195d55f8916b0677
https://doi.org/10.1007/978-1-4939-8663-7_17
https://doi.org/10.1007/978-1-4939-8663-7_17
Autor:
Daniel J. McKay, Brian D. Strahl, Robert J. Duronio, Michael P. Meers, Karen Adelman, A. Gregory Matera
Publikováno v:
BMC Genomics, Vol 19, Iss 1, Pp 1-20 (2018)
BMC Genomics
BMC Genomics
BackgroundHigh-resolution transcription start site (TSS) mapping in D. melanogaster embryos and cell lines has revealed a rich and detailed landscape of both cis- and trans-regulatory elements and factors. However, TSS profiling has not been investig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1185d8f8f3180ac1b63bf447950e095
Autor:
A. Gregory Matera, Michael P. Meers, Karen Adelman, Robert J. Duronio, Daniel J. McKay, Brian D. Strahl, Christopher A. Lavender, Telmo Henriques
Publikováno v:
eLife
eLife, Vol 6 (2017)
eLife, Vol 6 (2017)
Histone H3 lysine 36 methylation (H3K36me) is thought to participate in a host of co-transcriptional regulatory events. To study the function of this residue independent from the enzymes that modify it, we used a ‘histone replacement’ system in D