Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Martin Egli"'
Autor:
Anna Bisbe, Martin Maier, Tuyen Nguyen, Martin Egli, Jennifer L. S. Willoughby, Muthiah Manoharan, Ivan Zlatev, Masaaki Akabane-Nakata, Matt Hettinger, Shigeo Matsuda, Hartmut Jahns, Christopher R. Brown, Nate Taneja, Rajar M. Manoharan, Kallanthottathil G. Rajeev, Klaus Charisse
Publikováno v:
Nucleic Acids Research. 50:1221-1240
A critical challenge for the successful development of RNA interference-based therapeutics therapeutics has been the enhancement of their in vivo metabolic stability. In therapeutically relevant, fully chemically modified small interfering RNAs (siRN
Publikováno v:
Nucleic Acids Research
Even in high-quality X-ray crystal structures of oligonucleotides determined at a resolution of 1 Å or higher, the orientations of first-shell water molecules remain unclear. We used cryo neutron crystallography to gain insight into the H-bonding pa
Autor:
Mark K Schlegel, Derek K O'Flaherty, Maja M. Janas, Jason A. Gilbert, Namrata D. Erande, Ivan Zlatev, Shigeo Matsuda, Yongfeng Jiang, June Qin, Pawan Kumar, Rohan Degaonkar, Martha Mendez, Masaaki Akabane-Nakata, Muthiah Manoharan, Martin Egli, Lauren Blair Woods
Publikováno v:
Nucleic Acids Research
We recently reported the synthesis of 2′-fluorinated Northern-methanocarbacyclic (2′-F-NMC) nucleotides, which are based on a bicyclo[3.1.0]hexane scaffold. Here, we analyzed RNAi-mediated gene silencing activity in cell culture and demonstrated
Autor:
Pawan Kumar, Piet Herdewijn, Joel M. Harp, Ivan Zlatev, Muthiah Manoharan, Marie Capobianco, Martin Egli, Mark K Schlegel, Mikhail Abramov, Maja M. Janas, Charalambos Kaittanis, Yongfeng Jiang, Adam Castoreno, Rohan Degaonkar, Dale C. Guenther, Guy Schepers
Publikováno v:
Nucleic Acids Research
In this report, we investigated the hexopyranose chemical modification Altriol Nucleic Acid (ANA) within small interfering RNA (siRNA) duplexes that were otherwise fully modified with the 2'-deoxy-2'-fluoro and 2'-O-methyl pentofuranose chemical modi
Publikováno v:
Acta Crystallographica Section F Structural Biology Communications. 74:603-609
Crystals of left-handed Z-DNA [d(CGCGCG)]2diffract X-rays to beyond 1 Å resolution, feature a small unit cell (∼18 × 31 × 44 Å) and are well hydrated, with around 90 water molecules surrounding the duplex in the asymmetric unit. The duplex show
Autor:
Kallanthottathil G. Rajeev, Anna Bisbe, Gopal R Bommineni, Martin Egli, Lydia Perkins, Shigeo Matsuda, Martin Maier, Klaus Charisse, Dale C. Guenther, Muthiah Manoharan, Donald Foster, Joel M. Harp, Nate Taneja, Ivan Zlatev
Publikováno v:
Nucleic Acids Research. 46:8090-8104
Chemical modification is a prerequisite of oligonucleotide therapeutics for improved metabolic stability, uptake and activity, irrespective of their mode of action, i.e. antisense, RNAi or aptamer. Phosphate moiety and ribose C2'/O2' atoms are the mo
Autor:
Hartmut Jahns, Terry P. Lybrand, Mark K Schlegel, Joel M. Harp, Martin Egli, Pradeep S. Pallan, Muthiah Manoharan
Publikováno v:
Biochemistry. 59(49)
GNRA (N = A, C, G, or U; R = A or G) tetraloops are common RNA secondary structural motifs and feature a phosphate stacked atop a nucleobase. The rRNA sarcin/ricin loop (SRL) is capped by G ApGA, and the phosphate p stacks on G . We recently found th
Autor:
Namrata D. Erande, Mark K Schlegel, Martin Egli, Atsushi Mikami, Tyler Chickering, Ivan Zlatev, Lauren Blair Woods, Alexander V Kel'in, Shigeo Matsuda, Pradeep S. Pallan, Muthiah Manoharan
Publikováno v:
Nucleic Acids Research
Various chemical modifications have been identified that enhance potency of small interfering RNAs (siRNAs) and that reduce off-target effects, immune stimulation, and toxicities of metabolites of these therapeutic agents. We previously described 5
Autor:
Amanda K. McCullough, Martin Egli, Vladimir Vartanian, R. Stephen Lloyd, Jongchan Yeo, Miral Dizdaroglu, Naoto N. Tozaki, Erdem Coskun, Sanem Hosbas Coskun, Michael P. Stone, Pawel Jaruga, Irina G. Minko, Sheila S. David
Publikováno v:
DNA Repair (Amst)
Pre-mRNA encoding human NEIL1 undergoes editing by adenosine deaminase ADAR1 that converts a single adenosine to inosine, and this conversion results in an amino acid change of lysine 242 to arginine. Previous investigations of the catalytic efficien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ce12a2f9822ce2bfccbaac7c1ec4b82
https://escholarship.org/uc/item/72z2t1bq
https://escholarship.org/uc/item/72z2t1bq
Publikováno v:
Crystals, Vol 9, Iss 10, p 532 (2019)
Crystals
Volume 9
Issue 10
Crystals
Volume 9
Issue 10
The (4&prime
&rarr
6&prime
)-linked DNA homolog 2&prime
3&prime
dideoxy-&beta
D-glucopyranosyl nucleic acid (dideoxy-glucose nucleic acid or homo-DNA) exhibits stable self-pairing of the Watson&ndash
Crick and rever
&rarr
6&prime
)-linked DNA homolog 2&prime
3&prime
dideoxy-&beta
D-glucopyranosyl nucleic acid (dideoxy-glucose nucleic acid or homo-DNA) exhibits stable self-pairing of the Watson&ndash
Crick and rever