Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Mahmoud M. El-Mas"'
Publikováno v:
Inflammation Research. 69:217-231
The objective of the study was to test the hypothesis that nicotine guards against endotoxemia-associated renal inflammation and vasoconstrictor dysfunction via the activation of α7-nicotinic acetylcholine receptors (α7-nAChRs)/heme oxygenase-1 (HO
Publikováno v:
Saudi Pharmaceutical Journal : SPJ
Saudi Pharmaceutical Journal, Vol 28, Iss 1, Pp 127-135 (2020)
Saudi Pharmaceutical Journal, Vol 28, Iss 1, Pp 127-135 (2020)
Widely different exposure times to endotoxic insults have been employed in reported studies. The current experimental study systematically evaluated the time-course and sex influences of endotoxic insult on survivability and cardiovascular and renal
Publikováno v:
Pharmacological Reports. 71:782-793
Background Nicotine alleviates renal inflammation and injury induced by endotoxemia. This study investigated (i) the nicotine modulation of hemodynamic and renal vasodilatory responses to endotoxemia in rats, and (ii) roles of α7 or α4β2-nAChRs an
Publikováno v:
Clinical and experimental pharmacologyphysiologyREFERENCES. 48(9)
Evidence suggests that immunosuppressant therapies protect against harmful effects of endotoxaemia. In this study, we tested whether calcineurin-dependent (cyclosporine/tacrolimus) and -independent (sirolimus) immunosuppressants variably influence ne
Publikováno v:
Journal of Cardiovascular Pharmacology.
Inconsistent reports are available on the role of testosterone in end-organ damage caused by endotoxemia. Here, pharmacologic, surgical, and molecular studies were employed to assess the testosterone modulation of cardiovascular, autonomic, and perip
Publikováno v:
Prostaglandins & Other Lipid Mediators. 141:1-10
We recently reported that celecoxib, a selective cyclooxygenase-2 (COX2) inhibitor, counteracts the adverse circulatory and renal actions of cyclosporine (CSA). Despite the seemingly advantageous nature of this interaction particularly in clinical se
Autor:
Amal G. Omar, Neamah Mahjoub, Safaa H. Hammoud, Assaad A. Eid, Sahar Alkhansa, Mahmoud M. El-Mas
Publikováno v:
American Journal of Physiology-Renal Physiology. 315:F572-F582
Nephrotoxicity is a serious side effect for the immunosuppressant drug cyclosporine A(CSA). In this study, we tested the hypothesis that administration of calcium channel blockers such as verapamil or nifedipine ameliorates renal CSA-induced renal dy
Autor:
Mahmoud M. El-Mas, Bassam Hamam, Firas Kobeissy, Elham A. Afify, Ali H. Eid, Suzanne A. Nasser
Publikováno v:
Current pharmaceutical design. 27(18)
Atherosclerosis-related cardiovascular diseases (CVDs) are the leading cause of death globally. Several lines of evidence are supportive of the contributory role of vascular inflammation in atherosclerosis. Diverse immune cell types, including monocy
Publikováno v:
Brain research. 1756
Autonomic neuropathy contributes to cardiovascular derangements induced by endotoxemia. In this communication, we tested the hypothesis that androgenic hormones improve arterial baroreflex dysfunction and predisposing neuroinflammatory response cause
Autor:
Mohamed A. Fouda, Hanan M. El-Gowelli, Mohammed A. El-Lakany, Marwa Y. Sallam, Mahmoud M. El-Mas
Publikováno v:
Toxicology letters. 335
Endotoxic manifestations are diminished in female populations due to immune boosting actions of sex steroids. Considering that tobacco constituents including nicotine inhibit estrogen synthesis, we tested the hypothesis that nicotine exposure unveils