Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Liron Bar-Peled"'
Autor:
Islam Baiev, Jochen K. Lennerz, Lesli A. Kiedrowski, Mohammed Usman Syed, Chendi Li, Rebecca S. Heist, Samuel J. Klempner, Dejan Juric, Aaron N. Hata, Mustafa Sakhi, Katerina A. Fella, Ryan B. Corcoran, Alexa G. Michel, Justin F. Gainor, Junbing Zhang, Liron Bar-Peled, Jessica J. Lin, Meagan B. Ryan, Noritaka Tanaka, Giulia Siravegna
Publikováno v:
Cancer Discovery. 11:1913-1922
Mutant-selective KRASG12C inhibitors, such as MRTX849 (adagrasib) and AMG 510 (sotorasib), have demonstrated efficacy in KRASG12C-mutant cancers, including non–small cell lung cancer (NSCLC). However, mechanisms underlying clinical acquired resista
Autor:
Peter K. Vogt, Liron Bar-Peled, Jonathan R. Hart, Philipp Raffeiner, Marc S. Weinberg, Daniel García-Caballero
Publikováno v:
Proceedings of the National Academy of Sciences. 117:6571-6579
MYC controls the transcription of large numbers of long noncoding RNAs (lncRNAs). Since MYC is a ubiquitous oncoprotein, some of these lncRNAs probably play a significant role in cancer. We applied CRISPR interference (CRISPRi) to the identification
Autor:
Tatiani B. Lima, A.F.Z. Nascimento, Juliana Helena Costa Smetana, David M. Sabatini, Germanna Lima Righetto, Kuang Shen, Gustavo Fernando Mercaldi, Ana L S Silva, Liron Bar-Peled, Nadia Rasheed, Fabio C. Gozzo, Ricardo Aparicio
Publikováno v:
FEBS Open Bio
FEBS Open Bio, Vol 9, Iss 9, Pp 1589-1602 (2019)
FEBS Open Bio, Vol 9, Iss 9, Pp 1589-1602 (2019)
Ragulator is a pentamer composed of p18, MP1, p14, C7orf59, and hepatitis B virus X‐interacting protein (HBXIP; LAMTOR 1—5) which acts as a lysosomal scaffold of the Rag GTPases in the amino acid sensitive branch of TORC1 signaling. Here, we pres
Autor:
Gabriel M. Simon, Pablo Lara-Gonzalez, Benjamin F. Cravatt, Kenneth M. Lum, Michael Petrascheck, Daisuke Ogasawara, Arshad Desai, William H. Parsons, Armand B. Cognetta, Liron Bar-Peled, Alice L Chen, Alan To
Publikováno v:
Nature Chemical Biology. 15:453-462
Phenotypic screening has identified small-molecule modulators of aging, but the mechanism of compound action often remains opaque due to the complexities of mapping protein targets in whole organisms. Here, we combine a library of covalent inhibitors
Autor:
Michael Petrascheck, Liron Bar-Peled, Brian K. Kennedy, Elizabeth R Valentine, Rozina Kardakaris, Megan M. Blewett, Gregory M. Solis, Mark A. McCormick, Alice L Chen, Benjamin F. Cravatt, James R. Williamson
Publikováno v:
eLife
eLife, Vol 7 (2018)
eLife, Vol 7 (2018)
Aging impairs the activation of stress signaling pathways (SSPs), preventing the induction of longevity mechanisms late in life. Here, we show that the antibiotic minocycline increases lifespan and reduces protein aggregation even in old, SSP-deficie
Autor:
Benjamin F. Cravatt, Elizabeth R Valentine, Liron Bar-Peled, Michael Petrascheck, Mark A. McCormick, Alice L Chen, Megan M. Blewett, Rozina Kardakaris, Gregory M. Solis, Brian K. Kennedy, James R. Williamson
SummaryAging impairs the activation of Stress Signaling Pathways (SSPs), preventing the induction of longevity mechanisms late in life. Here we show that the antibiotic minocycline increases lifespan and reduces protein aggregation even in old, SSP-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c5307af6399385c3c28f7c1f4d5605b
Autor:
Dudley W. Lamming, Liron Bar-Peled
Publikováno v:
Traffic (Copenhagen, Denmark). 20(1)
For the past five decades, the lysosome has been characterized as an unglamorous cellular recycling center. This notion has undergone a radical shift in the last 10 years, with new research revealing that this organelle serves as a major hub for meta
Publikováno v:
Cell. 150(6):1196-1208
The mTOR Complex 1 (mTORC1) pathway promotes cell growth in response to a diverse set of cues, including growth factors as well as energy and amino acid levels. Amino acids signal through the Rag GTPases to promote the translocation of mTORC1 to the
Autor:
Yasemin Sancak, Roberto Zoncu, Shigeyuki Nada, Liron Bar-Peled, David M. Sabatini, Andrew L. Markhard
Publikováno v:
PMC
The mTORC1 kinase promotes growth in response to growth factors, energy levels, and amino acids, and its activity is often deregulated in disease. The Rag GTPases interact with mTORC1 and are proposed to activate it in response to amino acids by prom
Autor:
Ping Jiang, Enrique Saez, Benjamin D. Horning, Radu M. Suciu, Esther K. Kemper, Thomas A Paul, Keriann M. Backus, Jose Olucha, Liron Bar-Peled, Melissa M. Dix, Reuben J. Shaw, Taka-Aki Ichu, Matthew Merrill Hayward, Bernard P. Kok, Ekaterina V. Vinogradova, Nathan T. Ihle, Zhou Zhu, Max W. Chang, Robert U. Svensson, Benjamin F. Cravatt
Publikováno v:
Cell. 171:696-709.e23
The transcription factor NRF2 is a master regulator of the cellular antioxidant response, and it is often genetically activated in non-small-cell lung cancers (NSCLCs) by, for instance, mutations in the negative regulator KEAP1. While direct pharmaco