Zobrazeno 1 - 10
of 192
pro vyhledávání: '"Kevin J Harrington"'
Autor:
Keith C. Bible, Irene Brana, Mollie Leoni, Stephan Hackenberg, Jessica Bauman, Pol Specenier, Jérôme Fayette, Catherine Rose Scholz, Binaifer Balsara, Maria Jose Flor, Bridget Martell, Alan L. Ho, Robert I. Haddad, Valentina Boni, Caroline Even, Sjoukje F. Oosting, Sung-Bae Kim, Kevin J. Harrington, Nabil F. Saba, Francis P. Worden, Antonio Gualberto, Lisa Licitra, Ioanna Nixon, Deborah J. Wong, Myung-Ju Ahn
Publikováno v:
Journal of clinical oncology
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 39(17):JCO2002903, 1856-1864. AMER SOC CLINICAL ONCOLOGY
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 39(17):JCO2002903, 1856-1864. AMER SOC CLINICAL ONCOLOGY
PURPOSEMutations in the HRAS (m HRAS) proto-oncogene occur in 4%-8% of patients with recurrent and/or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC). Tipifarnib is a farnesyltransferase inhibitor that disrupts HRAS function. We evalua
Autor:
Jing Xie, Muzammil Ali, Kevin J. Harrington, Robert L. Ferris, Amanda Psyrri, Lisa Licitra, William C. Holmes, Stefano Cavalieri, Cristiana Bergamini, Gabriella Mariani
Publikováno v:
Head & Neck
Hemorrhage in recurrent and/or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) may be attributed to chemotherapy and local tumor irradiation. Evidence of the relationship between hemorrhage in R/M HNSCC and targeted therapies, includin
Autor:
M Dvorkin, Jean Bourhis, Antonio Rueda, Amanda Psyrri, József Lövey, Robert L. Ferris, Holger Thurm, Steven De Beukelaer, Mohammad Abdul Razaq, Kevin J. Harrington, Chaosu Hu, Lara Dunn, Jin-Ching Lin, Ezra E.W. Cohen, Makoto Tahara, Robert I. Haddad, Nancy Y. Lee, Dmitri Pavlov, Peter Mu Hsin Chang, Maria Margarida Teixeira, Jerome Chamois
Publikováno v:
The Lancet Oncology. 22:450-462
Summary Background Chemoradiotherapy is the standard of care for unresected locally advanced squamous cell carcinoma of the head and neck. We aimed to assess if addition of avelumab (anti-PD-L1) to chemoradiotherapy could improve treatment outcomes f
Autor:
Timothy Kottke, Laura Evgin, Christopher B. Driscoll, Phonphimon Wongthida, Jill Thompson, Brady Zell, Adel Samson, Jason M. Tonne, Amanda L. Huff, Lewis R. Roberts, Elizabeth Ilett, Peter Selby, Alan Melcher, Kevin J. Harrington, Jacob van Vloten, Mitesh J. Borad, Hardev Pandha, Matthew Schuelke, Richard G. Vile, Mark A. McNiven, Victoria A. Jennings, Jose S. Pulido
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
In our clinical trials of oncolytic vesicular stomatitis virus expressing interferon beta (VSV-IFNβ), several patients achieved initial responses followed by aggressive relapse. We show here that VSV-IFNβ-escape tumors predictably express a point-m
Autor:
M. Denyer, Nicola E. Annels, Guy Simpson, Kevin J. Harrington, Richard G. Vile, Mehreen Arif, Hardev Pandha, Alan Melcher, Matthew C. Coffey
Publikováno v:
Molecular Therapy Oncolytics
Molecular Therapy: Oncolytics, Vol 20, Iss, Pp 434-446 (2021)
Molecular Therapy: Oncolytics, Vol 20, Iss, Pp 434-446 (2021)
Prostate cancers are considered “cold” tumors characterized by minimal T cell infiltrates, absence of a type I interferon (IFN) signature, and the presence of immunosuppressive cells. This non-inflamed phenotype is likely responsible for the lack
Publikováno v:
Clinical Cancer Research. 27:689-703
Therapeutic cancer vaccines, an exciting development in cancer immunotherapy, share the goal of creating and amplifying tumor-specific T-cell responses, but significant obstacles still remain to their success. Here, we briefly outline the principles
Autor:
Burak Gumuscu, Kevin J. Harrington, Hoi-Shen Radcliffe, Lillian L. Siu, Wendy Snyder, Danny Rischin, Beatriz Castelo Fernandez, Ezra E.W. Cohen, Jason Chesney, Anthony Kong, Jonathan D. Cheng, Nicolas Mach
Publikováno v:
Clinical Cancer Research, Vol. 26, No 19 (2020) pp. 5153-5161
Purpose: The prognosis for patients with recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) is poor, and only a minority of patients benefit from checkpoint immunotherapy. Talimogene laherparepvec (T-VEC), an oncolytic immunoth
Autor:
F. Stephen Hodi, Kevin J. Harrington, Archie N. Tse, David C. Madoff, Jason J. Luke, Andrea Marie Perrone, Lawrence H. Schwartz, Anuradha D. Khilnani, Robert H.I. Andtbacka, Aurélien Marabelle, Gregory V. Goldmacher
Publikováno v:
Journal of Clinical Oncology
3141 Background: The approval of intratumoral (IT) immunotherapy for metastatic melanoma and the active development of numerous novel IT drugs have created a need for standardized evaluation of response to this unique treatment strategy. The Response
Autor:
Johannes A. Langendijk, Jordi Giralt, Matthias Guckenberger, Jørgen Johansen, John Waldron, Shlomo A. Koyfman, Danielle N. Margalit, Jimmy J. Caudell, Panagiotis Balermpas, Ying J. Hitchcock, Johannes H.A.M. Kaanders, Sandro V. Porceddu, Jonathan J. Beitler, Pierre Blanchard, Yoke Lim Soong, Michelle Mierzwa, June Corry, David M. Brizel, Wilfred Budach, David A. Palma, Sue S. Yom, Adam S. Garden, Vincent Grégoire, Nancy Y. Lee, Mererid Evans, Renzo Corvò, Ying Sun, Quynh-Thu Le, Kevin J. Harrington, Paul M. Harari, Juliette Thariat, David J Thomson
Publikováno v:
Radiotherapy and Oncology, 151, pp. 314-321
International Journal of Radiation Oncology, Biology, Physics, 107, 618-627
Scientia
Radiotherapy and Oncology, 151, 314-321. ELSEVIER IRELAND LTD
Thomson, D J, Palma, D, Guckenberger, M, Balermpas, P, Beitler, J J, Blanchard, P, Brizel, D, Budach, W, Caudell, J, Corry, J, Corvo, R, Evans, M, Garden, A S, Giralt, J, Gregoire, V, Harari, P M, Harrington, K, Hitchcock, Y J, Johansen, J, Kaanders, J, Koyfman, S, Langendijk, J A, Le, Q T, Lee, N, Margalit, D, Mierzwa, M, Porceddu, S, Soong, Y L, Sun, Y, Thariat, J, Waldron, J & Yom, S S 2020, ' Practice Recommendations for Risk-Adapted Head and Neck Cancer Radiation Therapy During the COVID-19 Pandemic : An ASTRO-ESTRO Consensus Statement ', International Journal of Radiation Oncology Biology Physics, vol. 107, no. 4, pp. 618-627 . https://doi.org/10.1016/j.ijrobp.2020.04.016
International journal of radiation oncology, biology, physics, vol 107, iss 4
International Journal of Radiation Oncology, Biology, Physics
Thomson, D J, Palma, D, Guckenberger, M, Balermpas, P, Beitler, J J, Blanchard, P, Brizel, D, Budach, W, Caudell, J, Corry, J, Corvo, R, Evans, M, Garden, A S, Giralt, J, Gregoire, V, Harari, P M, Harrington, K, Hitchcock, Y J, Johansen, J, Kaanders, J, Koyfman, S, Langendijk, J A, Le, Q T, Lee, N, Margalit, D, Mierzwa, M, Porceddu, S, Soong, Y L, Sun, Y, Thariat, J, Waldron, J & Yom, S S 2020, ' Practice recommendations for risk-adapted head and neck cancer radiotherapy during the COVID-19 pandemic : An ASTRO-ESTRO consensus statement ', Radiotherapy and Oncology, vol. 151, pp. 314-321 . https://doi.org/10.1016/j.radonc.2020.04.019
Radiotherapy and Oncology, 151, 314-321
Radiotherapy and Oncology
International Journal of Radiation Oncology, Biology, Physics, 107, 4, pp. 618-627
International Journal of Radiation Oncology, Biology, Physics, 107(4), 618-627. ELSEVIER SCIENCE INC
International Journal of Radiation Oncology, Biology, Physics, 107, 618-627
Scientia
Radiotherapy and Oncology, 151, 314-321. ELSEVIER IRELAND LTD
Thomson, D J, Palma, D, Guckenberger, M, Balermpas, P, Beitler, J J, Blanchard, P, Brizel, D, Budach, W, Caudell, J, Corry, J, Corvo, R, Evans, M, Garden, A S, Giralt, J, Gregoire, V, Harari, P M, Harrington, K, Hitchcock, Y J, Johansen, J, Kaanders, J, Koyfman, S, Langendijk, J A, Le, Q T, Lee, N, Margalit, D, Mierzwa, M, Porceddu, S, Soong, Y L, Sun, Y, Thariat, J, Waldron, J & Yom, S S 2020, ' Practice Recommendations for Risk-Adapted Head and Neck Cancer Radiation Therapy During the COVID-19 Pandemic : An ASTRO-ESTRO Consensus Statement ', International Journal of Radiation Oncology Biology Physics, vol. 107, no. 4, pp. 618-627 . https://doi.org/10.1016/j.ijrobp.2020.04.016
International journal of radiation oncology, biology, physics, vol 107, iss 4
International Journal of Radiation Oncology, Biology, Physics
Thomson, D J, Palma, D, Guckenberger, M, Balermpas, P, Beitler, J J, Blanchard, P, Brizel, D, Budach, W, Caudell, J, Corry, J, Corvo, R, Evans, M, Garden, A S, Giralt, J, Gregoire, V, Harari, P M, Harrington, K, Hitchcock, Y J, Johansen, J, Kaanders, J, Koyfman, S, Langendijk, J A, Le, Q T, Lee, N, Margalit, D, Mierzwa, M, Porceddu, S, Soong, Y L, Sun, Y, Thariat, J, Waldron, J & Yom, S S 2020, ' Practice recommendations for risk-adapted head and neck cancer radiotherapy during the COVID-19 pandemic : An ASTRO-ESTRO consensus statement ', Radiotherapy and Oncology, vol. 151, pp. 314-321 . https://doi.org/10.1016/j.radonc.2020.04.019
Radiotherapy and Oncology, 151, 314-321
Radiotherapy and Oncology
International Journal of Radiation Oncology, Biology, Physics, 107, 4, pp. 618-627
International Journal of Radiation Oncology, Biology, Physics, 107(4), 618-627. ELSEVIER SCIENCE INC
Càncer de cap i coll; Radioteràpia; Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV Cáncer de cabeza y cuello; Terapia de radiación; Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV Head and Neck Cancer; Radiation Therapy; Coronavirus SARS-CoV-2; COVID-19
Autor:
Kabir Mohammed, Myles Smith, David Mansfield, Hayden Snow, Christina Messiou, Stephen Hazell, Emma Davies, David Nicol, Stephanie O'Neill, Nabil Hujairi, Kevin J. Harrington, Nicholas Francis
Publikováno v:
Journal of Cutaneous Pathology. 47:1115-1122
Background Prostate-specific membrane antigen (PSMA) is a prostatic epithelial protein that is used as a radiotracer (68Ga-PSMA-11) for prostate cancer staging. PSMA-PET/CT (positron emission tomography/computed tomography) performed for prostate can