Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Karel Souček"'
Autor:
Sára Lenárt, Peter Lenárt, Lucia Knopfová, Hana Kotasová, Vendula Pelková, Veronika Sedláková, Vladimír Čan, Jan Šmarda, Karel Souček, Aleš Hampl, Petr Beneš
TACSTD2 encodes a transmembrane glycoprotein Trop2 commonly overexpressed in carcinomas. While the Trop2 protein was discovered already in 1981 and first antibody-drug conjugate targeting Trop2 were recently approved cancer therapy, the physiological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7f1ccc011d8be1bda0430a0a7ec71ed
https://doi.org/10.1101/2021.06.29.450320
https://doi.org/10.1101/2021.06.29.450320
Publikováno v:
Cancers
Cancers, Vol 13, Iss 2188, p 2188 (2021)
Cancers, Vol 13, Iss 2188, p 2188 (2021)
Simple Summary Epithelial–mesenchymal transition (EMT) and its reverse process mesenchymal–epithelial transition (MET) are considered critical events in the cancer progression. These programs are tightly connected with the development of metastas
Autor:
Daniela Kurfürstová, Milan Král, Alena Mickova, Jan Bouchal, Barbora Pokryvkova, Mariam Gachechiladze, Ondrej Vacek, Karel Souček, Martin Mistrik, Gvantsa Kharaishvili
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 2844, p 2844 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 6
International Journal of Molecular Sciences
Volume 22
Issue 6
Prostate cancer (PCa) is the second leading cause of cancer-related deaths in men in Western countries, and there is still an urgent need for a better understanding of PCa progression to inspire new treatment strategies. Skp2 is a substrate-recruitin
Autor:
Vondálová Blanářová O, Karel Souček, Michaela Nosková, Víchová R, Kristína Gömöryová, Gybel’ T, Zbynek Zdrahal, Karol Kaiser, Lucia Kucerova, Lucia Demkova, Bryja, David Potěšil, Katarzyna Anna Radaszkiewicz, Markéta Pícková, Tomasz Witold Radaszkiewicz
RNF43 is a E3 ubiquitin ligase and known negative regulator of WNT/β-catenin signaling. We demonstrate that RNF43 is also regulator of noncanonical WNT5A-induced signaling in human cells. Analysis of the RNF43 interactome using BioID and immunopreci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::259dd6982413886159ca97f70622272a
https://doi.org/10.1101/2021.02.08.430210
https://doi.org/10.1101/2021.02.08.430210
Autor:
Stanislav Drápela, Miroslav Boudny, Josef Jaroš, Michaela Špunarová, Jan Verner, Prashant Khirsariya, Zuzana Jašková, Kamil Paruch, Yvona Brychtová, Marie Kasparkova, Jana Zemanová, Jiri Mayer, Marek Borsky, Václav Šeda, Jana Černá, Martin Trbušek, Alexandra Oltová, Marek Mráz, Karel Souček
Publikováno v:
Haematologica
Introduction of small-molecule inhibitors of B-cell receptor signaling and BCL2 protein significantly improves therapeutic options in chronic lymphocytic leukemia. However, some patients suffer from adverse effects mandating treatment discontinuation
Autor:
Herbert Waldmann, Jana Flegel, Slava Ziegler, Barbora Valčíková, Stjepan Uldrijan, Sonja Sievers, Michaela Hylsová, Apirat Chaikuad, Stefan Knapp, Benedict-Tilman Berger, Lukáš Maier, Martin Schröder, Vaclav Nemec, Karel Souček, Stanislav Drápela, Kamil Paruch
Publikováno v:
Angewandte Chemie International Edition. 58:1062-1066
Reported is the identification of the furo[3,2-b]pyridine core as a novel scaffold for potent and highly selective inhibitors of cdc-like kinases (CLKs) and efficient modulators of the Hedgehog signaling pathway. Initially, a diverse target compound
Autor:
Ján Remšík, Aleš Hampl, Lucia Binó, Eva Slabáková, Karel Souček, Zuzana Kahounová, Daniela Kurfűrstová, Volodymyr Porokh, Radek Fedr, Vladimír Študent, Jan Bouchal, Radek Vrtěl, Lucie Jurečková
Publikováno v:
Stem Cell Research, Vol 33, Iss, Pp 255-259 (2018)
A human induced pluripotent stem cell line was generated from cancer-associated fibroblasts of a 68-years old patient with diagnosed prostate adenocarcinoma (PCa). The fibroblast cell line was reprogrammed with Epi5™ Episomal iPSC Reprogramming Kit
Autor:
Lucie Jurečková, Veronika Pospíšilová, Petr Vaňhara, Aleš Hampl, Zuzana Holubcová, Vendula Pelková, Daniela Mináriková, Tomáš Bárta, Karel Souček, Dáša Bohačiaková, Volodymyr Porokh
Publikováno v:
Stem Cells and Development. 27:1077-1084
Chromosomal instability evoked by abnormalities in centrosome numbers has been traditionally considered as a hallmark of aberrant, typically cancerous or senescent cells. We have reported previously that pristine human embryonic stem cells (hESC) suf
Autor:
Jan Bouchal, Wytske M. van Weerden, Vladimír Študent, Zoran Culig, Martin Morong, Stanislav Drápela, Daniela Kurfürstová, Barbora Kvokackova, Radek Fedr, Martin Puhr, Karel Souček
BackgroundDocetaxel resistance represents a leading obstacle in the therapy of prostate cancer (PCa), resulting in lethal disease. Intratumoral heterogeneity, which is frequently driven by epithelial-mesenchymal plasticity significantly contributes t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c06e0a02611c88c6759b3e22b9c27403
https://doi.org/10.1101/2021.01.28.428577
https://doi.org/10.1101/2021.01.28.428577
Autor:
Zbyněk Zdráhal, Olga Vondálová Blanářová, Tomáš Gybeľ, Markéta Pícková, Lucia Kucerova, Ráchel Víchová, Kristína Gömöryová, Tomasz Witold Radaszkiewicz, Karol Kaiser, Vítězslav Bryja, David Potěšil, Tomáš Bárta, Michaela Nosková, Karel Souček, Lucia Demkova, Katarzyna Anna Radaszkiewicz
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
RNF43 is an E3 ubiquitin ligase and known negative regulator of WNT/β-catenin signaling. We demonstrate that RNF43 is also a regulator of noncanonical WNT5A-induced signaling in human cells. Analysis of the RNF43 interactome using BioID and immunopr