Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Kalvis Hornburg"'
Autor:
Robert A. Redd, Matthew Leventhal, Irene M. Ghobrial, Nikhil C. Munshi, Christopher J. Gibson, Jerome Ritz, Amin Nassar, Chip Stewart, Jihye Park, Romanos Sklavenitis-Pistofidis, Marzia Capelletti, Cody J. Boehner, David P. Steensma, Saud H. AlDubayan, Daniel Auclair, Lorenzo Trippa, Muhieddine M. Itani, Benjamin L. Ebert, Kalvis Hornburg, Shaadi Mehr, Mark Bustoros, Robert L. Schlossman, Henry Dumke, Jacob P. Laubach, Adam S. Sperling, Gad Getz, Salomon Manier, Paul G. Richardson, Eliezer M. Van Allen, Tarek H. Mouhieddine, Sabrin Tahri, Kenneth C. Anderson, Robert J. Soiffer, Daisy Huynh, Donna Neuberg, Brendan Reardon, Chia Jen Liu, Jonathan J Keats
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Nature Communications
Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.2996. ⟨10.1038/s41467-020-16805-5⟩
Nature Communications, 2020, 11 (1), pp.2996. ⟨10.1038/s41467-020-16805-5⟩
Nature Communications
Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.2996. ⟨10.1038/s41467-020-16805-5⟩
Nature Communications, 2020, 11 (1), pp.2996. ⟨10.1038/s41467-020-16805-5⟩
Multiple myeloma (MM) is a plasma-cell neoplasm that is treated with high-dose chemotherapy, autologous stem cell transplant (ASCT) and long-term immunomodulatory drug (IMiD) maintenance. The presence of somatic mutations in the peripheral blood is t
Autor:
Peter Sabbatini, Stacey Chuma, Rachid Baz, Jacob P. Laubach, Robert A. Redd, Alexandra Savell, Raymond P. Perez, Pamela S. Becker, Patrick Henrick, Kenneth C. Anderson, Oksana Zavidij, Chia Jen Liu, Kalvis Hornburg, Romanos Sklavenitis-Pistofidis, Michael Robbins, Kaitlen Reyes, Paul G. Richardson, Irene M. Ghobrial
Publikováno v:
Clinical Cancer Research. 26:344-353
Purpose: Ulocuplumab (BMS-936564) is a first-in-class fully human IgG4 monoclonal anti-CXCR4 antibody that inhibits the binding of CXCR4 to CXCL12. Patients and Methods: This phase Ib/II study aimed to determine the safety and tolerability of ulocupl
Autor:
Edie Weller, Kaitlen Reyes, James J. Vredenburgh, Adam Boruchov, Kimberly Noonan, Paul G. Richardson, Rachid Baz, Jacob P. Laubach, Abdel Kareem Azab, Houry Leblebjian, Robert L. Schlossman, Irene M. Ghobrial, Frank G. Basile, Pamela A. Crilley, Kenneth C. Anderson, Patrick Henrick, Michael Constantine, Stacey Chuma, Nikhil C. Munshi, Kenneth H. Shain, Kalvis Hornburg, Claudia E. Paba-Prada, Philippe Armand, Diane Warren, Yuji Mishima, Lorenzo Trippa, Chia Jen Liu, Oksana Zavidij
Publikováno v:
American Journal of Hematology. 94:1244-1253
We tested the hypothesis that using CXCR4 inhibition to target the interaction between the tumor cells and the microenvironment leads to sensitization of the tumor cells to apoptosis. Eligibility criteria included multiple myeloma (MM) patients with
Autor:
Philippe Armand, Damian R. Handisides, Irene M. Ghobrial, Jacalyn Rosenblatt, Kenneth C. Anderson, Jacquelyn Hedlund, Paul G. Richardson, Henry Dumke, Bradley Rivotto, Stacey Chuma, Robert L. Schlossman, Kenneth H. Shain, Stew Kroll, Patrick Henrick, Chia Jen Liu, Noopur Raje, Michael Gary Martin, Alexandra Savell, Andrew Yee, Craig Reynolds, Kalvis Hornburg, Laura Stampleman, Jacob P. Laubach, Ira Zackon
Publikováno v:
Clinical Cancer Research. 25:478-486
Purpose: The presence of hypoxia in the diseased bone marrow presents a new therapeutic target for multiple myeloma. Evofosfamide (formerly TH-302) is a 2-nitroimidazole prodrug of the DNA alkylator, bromo-isophosphoramide mustard, which is selective
Autor:
Choi-Fong Cho, Kalvis Hornburg, David Calligaris, Nathalie Y. R. Agar, Colin M. Fadzen, Sean E. Lawler, Justin M. Wolfe, Bradley L. Pentelute, E. Antonio Chiocca
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Nature
Nature Communications
Nature
Nature Communications
Culture-based blood–brain barrier (BBB) models are crucial tools to enable rapid screening of brain-penetrating drugs. However, reproducibility of in vitro barrier properties and permeability remain as major challenges. Here, we report that self-as
Autor:
Kenneth C. Anderson, Donna Neuberg, Romanos Sklavenitis-Pistofidis, Marzia Capelletti, Daniel Auclair, Kalvis Hornburg, Mark Bustoros, Tarek H. Mouhieddine, Irene M. Ghobrial, Brendan Reardon, Muhieddine M. Itani, Robert L. Schlossman, Jacob P. Laubach, Jerome Ritz, Jihye Park, Daisy Huynh, Salomon Manier, Chia Jen Liu, Paul G. Richardson, Nikhil C. Munshi, Christopher J. Gibson, Robert J. Soiffer, Eliezer M. Van Allen, Benjamin L. Ebert, Saud H. AlDubayan, Henry Dumke, Cody J. Boehner, Robert A. Redd, Amin Nassar, David P. Steensma
Publikováno v:
Blood. 132:749-749
Introduction: Multiple Myeloma (MM) is a clonal plasma cell malignancy, accounting for 10% of all hematological malignancies. Genetic analyses of large populations revealed that blood-specific somatic mutations in hematopoietic stem cells (HSCs) are
Autor:
Daisy Huynh, Benjamin L. Ebert, Paul G. Richardson, Irene M. Ghobrial, Jerome Ritz, Kenneth C. Anderson, Mark Bustoros, Saud H. AlDubayan, Nikhil C. Munshi, Christopher J. Gibson, Donna Neuberg, Chia-Jen Lui, Brendan Reardon, Jacob P. Laubach, Robert L. Schlossman, Jihye Park, Amin Nassar, Salomon Manier, David P. Steensma, Tarek H. Mouhieddine, Kalvis Hornburg, Marzia Capelletti, Robert J. Soiffer, Henry Dumke, Romanos Sklavenitits Pistofidis, Darlys Schott, Cody J. Boehner, Eliezer M. Van Allen, Robert A. Redd
Publikováno v:
Cancer Research. 78:2954-2954
Introduction: Multiple Myeloma (MM) is a clonal plasma cell malignancy, accounting for 10% of all hematological malignancies. Genetic analyses of large populations revealed that blood-specific somatic mutations in hematopoietic stem cells (HSCs) are