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pro vyhledávání: '"Jonathan L.C. Lee"'
Publikováno v:
Learn Mem
The efficacy of pharmacological disruption of fear memory reconsolidation depends on several factors, including memory strength and age. We built on previous observations that systemic treatment with the nootropic nefiracetam potentiates cued fear me
Publikováno v:
Psychopharmacology
Rationale Pharmacological targeting of memory reconsolidation is a promising therapeutic strategy for the treatment of fear memory-related disorders. However, the success of reconsolidation-based approaches depends upon the effective destabilisation
Publikováno v:
Frontiers in Behavioral Neuroscience
Frontiers in Behavioral Neuroscience, Vol 13 (2019)
Frontiers in Behavioral Neuroscience, Vol 13 (2019)
Reconsolidation normally functions to update and maintain memories in the long-term. However, this process can be disrupted pharmacologically to weaken memories. Exploiting such experimental amnesia to disrupt the maladaptive reward memories underpin
Publikováno v:
Trends in Cognitive Sciences. 21:531-545
The reactivation of a synaptically stored memory in the brain can make the memory transiently labile. During the time it takes for the memory to re-stabilize (reconsolidate), the memory can either be reduced by an amnesic agent or enhanced by memory
Autor:
Kai Rong Tay, Maria Wimber, Charlotte R. Flavell, Jonathan L.C. Lee, Lindsey de Freitas Cassini
Publikováno v:
The Journal of Neuroscience
Memory reconsolidation is hypothesized to be a mechanism by which memories can be updated with new information. Such updating has previously been shown to weaken memory expression or change the nature of the memory. Here we demonstrate that retrieval
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e47faf45e5cfa23ee61859e2b1069a1
https://eprints.gla.ac.uk/225925/1/225925.pdf
https://eprints.gla.ac.uk/225925/1/225925.pdf
Reconsolidation is a process in which re-exposure to a reminder causes a previously acquired memory to undergo a process of destabilisation followed by subsequent restabilisation. Different molecular mechanisms have been postulated for destabilisatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f237333f7570a48ca66c70ebb8ffaf6a
Publikováno v:
Behavioural Brain Research. 393:112774
Studies of memory reconsolidation of pavlovian memories have typically employed unimodal conditioned stimuli, despite the use of multimodal compound stimuli in other settings. Here we studied sign-tracking behaviour to a compound audiovisual stimulus
Autor:
Harriet L L Day, Francisco Silveira Guimarães, Leandro J. Bertoglio, Carl W. Stevenson, Regimantas Jurkus, Jonathan L.C. Lee
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Frontiers in Pharmacology, Vol 7 (2016)
Frontiers in Pharmacology
Universidade de São Paulo (USP)
instacron:USP
Frontiers in Pharmacology, Vol 7 (2016)
Frontiers in Pharmacology
Anxiety and trauma-related disorders are psychiatric diseases with a lifetime prevalence of up to 25%. Phobias and post-traumatic stress disorder (PTSD) are characterized by abnormal and persistent memories of fear-related contexts and cues. The effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d26d256b1d98cd929e7b60f82d31d566
http://eprints.nottingham.ac.uk/38709/
http://eprints.nottingham.ac.uk/38709/
Publikováno v:
Learn Mem
Learn Mem, 2010, 17 (9), pp.444-53. ⟨10.1101/lm.1757410⟩
Learn Mem, 2010, 17 (9), pp.444-53. ⟨10.1101/lm.1757410⟩
A distributed limbic-corticostriatal circuitry is implicated in cue-induced drug craving and relapse. Exposure to drug-paired cues not only precipitates relapse, but also triggers the reactivation and reconsolidation of the cue-drug memory. However,
Publikováno v:
Frontiers in Behavioral Neuroscience
Frontiers in Behavioral Neuroscience, Vol 8 (2014)
Frontiers in Behavioral Neuroscience, Vol 8 (2014)
The reactivation of a memory can result in its destabilization, necessitating a process of memory reconsolidation to maintain its persistence. Here we show that the destabilization of a contextual fear memory is potentiated by the cannabinoid CB1 rec