Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Jingwen Chen"'
Autor:
Qi Zhao, Dongsheng Yu, Jiayue Liu, Jiacheng Lin, Jingwen Chen, Jiaxuan Lu, Wenqing Li, Xin Yang, Wei Zhao
Publikováno v:
Stem Cells International, Vol 2021 (2021)
Graphene oxide quantum dots (GOQDs) are a carbon nanomaterial with broad potential for application in the field of nanomaterial biomedicine. Stem cells from human exfoliated deciduous teeth (SHEDs) play an important role in tissue engineering and reg
Publikováno v:
Chemical Research in Toxicology. 33:1382-1388
Peroxisome proliferator activator receptor gamma (PPARγ) agonist activity of chemicals is an indicator of concerned health conditions such as fatty liver and obesity. In silico screening PPARγ agonists based on quantitative structure-activity relat
Publikováno v:
Chemical Science
Azido-functionalized poly-ADP-ribose (PAR) polymers were conjugated with anti-HER2 antibodies and tubulin inhibitors to generate a PAR polymer-based antibody-drug conjugate with potent and specific cytotoxicity toward HER2-expressing cancer cells.
Autor:
Jingmei Wang, Zhenqian Huang, Jingwen Chen, Weidong Ding, Yan Ren, Yusaku Nakabeppu, Jiaqi Kang, Yimei Fan, Xin Wu, Wei Gao, Xiang Lu, Yaping Wang
Publikováno v:
Free Radical Biology and Medicine. 143:482-493
8-oxoguanine (8-oxoG) is one of the most prevalent genotoxic lesions, and it is generated in DNA attacked by reactive oxygen species (ROS). Adenine misincorporated opposite to 8-oxoG during replication is excised by MutY homolog (MUTYH), an important
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
As a highly prevalent disease among women worldwide, breast cancer remains in urgent need of further elucidation its molecular mechanisms to improve the patient outcomes. Identifying hub genes involved in the pathogenesis and progression of breast ca
Publikováno v:
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
The ubiquitin (Ub)–proteasome system (UPS) is an important regulatory component in colorectal cancer (CRC), and the cell cycle is also characterized to play a significant role in CRC. In this present study, we firstly identified UPS-associated diff
Autor:
Shun Zhang, Zhiyuan Tian, Tao Xia, Pei Li, Jingwen Chen, Qian Zhao, Luming Liu, Aiguo Wang, Guoyu Zhou, Qiang Niu, Chen Luo, Lixin Dong
Publikováno v:
Science of The Total Environment. 645:363-371
Brominated flame retardant 2,2′,4,4′‑tetrabromodiphenyl ether (PBDE-47) is known to induce developmental neurotoxicity by disturbing thyroid hormones (THs). Evidence shows that maternal THs are crucial for brain development and growth of fetuse
Autor:
Jingwen Chen, Shun Zhang, Pei Li, Chunyan Xu, Tao Xia, Guoyu Zhou, Qian Zhao, Qiang Niu, Lixin Dong, Aiguo Wang
Publikováno v:
Toxicology. 410:222-230
Excessive exposure to fluoride has adverse effects on neurodevelopment, but the mechanisms remain unclear. This study aimed to investigate the effects of fluoride exposure on synaptogenesis, and focused on the role of brain-derived neurotrophic facto
Publikováno v:
Journal of Environmental Science and Health, Part C. 36:252-271
Humans and wildlife inhabit a world with panoply of natural and synthetic chemicals. Alarmingly, only a limited number of chemicals have undergone comprehensive toxicological evaluation due to limitations of traditional toxicity testing. High-through
Publikováno v:
Environmental Pollution. 240:68-76
Microcystin-LR (MC-LR) is the most abundant toxicant among microcystin variants produced by cyanobacteria. MC-induced toxicity is broadly reported to pose a threat to aquatic animals and humans and has been associated with the dysfunction of some org