Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Jiayu Zhou"'
Publikováno v:
Environmental Microbiology. 22:1421-1434
Lycoris radiata is a main source of Amaryllidaceae alkaloids; however, the low content of these alkaloids in planta remains a limit to their pharmaceutical development and utilization. The accumulation of secondary metabolites can be enhanced in plan
Publikováno v:
International Journal of Biological Macromolecules. 148:908-920
Although digestive resistance of Kunitz protease inhibitors has been reported extensively, the molecular mechanism is not well established. In the present study, the first X-ray structure of Cassia obtusifolia trypsin inhibitor (COTI), a member of Ku
Publikováno v:
Clinical & Experimental Metastasis. 37:115-124
Cullin 3 (CUL3), a molecular scaffold of Cullin-RING ubiquitin ligase, plays an important role in regulating biological processes through modulating the ubiquitylation and degradation of various protein substrates. Dysfunction of CUL3 is implicated i
Publikováno v:
Briefings in Bioinformatics. 21:919-935
Despite the fact that deep learning has achieved remarkable success in various domains over the past decade, its application in molecular informatics and drug discovery is still limited. Recent advances in adapting deep architectures to structured da
Publikováno v:
Evidence-Based Complementary and Alternative Medicine, Vol 2021 (2021)
Evidence-based Complementary and Alternative Medicine : eCAM
Evidence-based Complementary and Alternative Medicine : eCAM
Objective. To explore the mechanism of action of Citri Reticulatae Pericarpium-Pinelliae Rhizoma (CRP-PR) in treating gastric cancer (GC) by using pharmacology network. Methods. Based on oral bioavailability and drug-likeness, the main active compone
Publikováno v:
BMC Plant Biology, Vol 20, Iss 1, Pp 1-14 (2020)
BMC Plant Biology
BMC Plant Biology
BackgroundTheLycorisgenus includes many ornamentally and medicinally important species. Polyploidization and hybridization are considered modes of speciation in this genus, implying great genetic diversity. However, the lack of effective molecular ma
Publikováno v:
Microbiological research. 239
Lycoris radiata is the major source of Amaryllidaceae alkaloids, having various medicinal activities. However, the low content of these alkaloids in planta limits their pharmaceutical development and utilization. In this study, the ability of bacteri
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
The search for early biomarkers of mild cognitive impairment (MCI) has been central to the Alzheimer’s Disease (AD) and dementia research community in recent years. To identify MCI status at the earliest possible point, recent studies have shown th
Publikováno v:
JAMIA Open
Objective The growing availability of rich clinical data such as patients’ electronic health records provide great opportunities to address a broad range of real-world questions in medicine. At the same time, artificial intelligence and machine lea
Autor:
Wenjie Zhang, Bo Pan, Xu Zhou, Dan Li, Hengyun Sun, Wei Liu, Chen Zhang, Zhiyong Zhang, Jiayu Zhou, Yu Liu, Guangdong Zhou, Zongqi Yin, Yilin Cao, Qingguo Zhang, Aijuan He, Haiyue Jiang
Publikováno v:
EBioMedicine, Vol 28, Iss C, Pp 287-302 (2018)
EBioMedicine
EBioMedicine
Microtia is a congenital external ear malformation that can seriously influence the psychological and physiological well-being of affected children. The successful regeneration of human ear-shaped cartilage using a tissue engineering approach in a nu