Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Hannu Koistinen"'
Autor:
Ulf-Håkan Stenman, Hannu Koistinen, Paco Hulpiau, Cedric Hermans, Benedicte Y. De Winter, Nikita Hanning, Ingrid De Meester, Hannah Ceuleers, Maya Berg, Joris G. De Man, Anne-Marie Lambeir, Michelle De bruyn
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 10711, p 10711 (2021)
International journal of molecular sciences
International Journal of Molecular Sciences
Volume 22
Issue 19
International journal of molecular sciences
International Journal of Molecular Sciences
Volume 22
Issue 19
The protease activity in inflammatory bowel disease (IBD) and irritable bowel syndrome has been studied extensively using synthetic fluorogenic substrates targeting specific sets of proteases. We explored activities in colonic tissue from a 2,4,6-tri
Autor:
Qing Yin, Shyamal D. Peddada, Ulf-Håkan Stenman, Nicole R. Bush, Henrik Alfthan, Jennifer J. Adibi, Kaja Z. LeWinn, Ashok Panigrahy, Xiaoshuang Xun, Hannu Koistinen, Frances A. Tylavsky, Yaqi Zhao
Publikováno v:
Journal of the Endocrine Society
Journal of the Endocrine Society, vol 5, iss 5
Journal of the Endocrine Society, vol 5, iss 5
Adequate maternal thyroid hormone (TH) is necessary for fetal brain development. The role of placental human chorionic gonadotropin (hCG) in ensuring the production of TH is less well understood. The objective of the study was to evaluate 1) associat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4343114eca2dd0f182198e074ea8cb58
http://hdl.handle.net/10138/335086
http://hdl.handle.net/10138/335086
Autor:
Carolin Stürenberg, Andrew Erickson, Adrian Malen, Hannu Koistinen, Ian G. Mills, Antti Rannikko, Tuomas Mirtti, Timo-Pekka Lehto
Publikováno v:
Lehto, T-P K, Stürenberg, C, Malén, A, Erickson, A M, Koistinen, H, Mills, I G, Rannikko, A & Mirtti, T 2021, ' Transcript analysis of commercial prostate cancer risk stratification panels in hard-to-predict grade group 2-4 prostate cancers ', Prostate . https://doi.org/10.1002/pros.24108
BACKGROUND: Improved prognostication is needed to minimize overtreatment in grade group (GG) 2-4 prostate cancer. Our aim was to determine, at messenger RNA (mRNA) level, the performance of the genes in the commercial panels Decipher, Oncotype DX, Pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::473eafad4598f5240f161f088b18ca9a
https://ora.ox.ac.uk/objects/uuid:9d0ce665-99ea-47b8-9e93-1d291da422b6
https://ora.ox.ac.uk/objects/uuid:9d0ce665-99ea-47b8-9e93-1d291da422b6
Autor:
Ulf-Håkan Stenman, Jouni Jokela, Hannu Koistinen, Kaarina Sivonen, Antti Poso, Matti Wahlsten, Perttu Permi, David P. Fewer, Tomas Strandin, Danillo O. Alvarenga, Matthias Nees, Mikko Metsä-Ketelä, Muhammad N. Ahmed
Publikováno v:
ACS Chemical Biology
Ahmed, M N, Wahlsten, M, Jokela, J, Nees, M, Stenman, U-H, Alvarenga, D O, Strandin, T, Sivonen, K, Poso, A, Permi, P, Metsä-Ketelä, M, Koistinen, H & Fewer, D P 2021, ' Potent Inhibitor of Human Trypsins from the Aeruginosin Family of Natural Products ', ACS chemical biology, vol. 16, no. 11, pp. 2537–2546 . https://doi.org/10.1021/acschembio.1c00611
Ahmed, M N, Wahlsten, M, Jokela, J, Nees, M, Stenman, U-H, Alvarenga, D O, Strandin, T, Sivonen, K, Poso, A, Permi, P, Metsä-Ketelä, M, Koistinen, H & Fewer, D P 2021, ' Potent Inhibitor of Human Trypsins from the Aeruginosin Family of Natural Products ', ACS chemical biology, vol. 16, no. 11, pp. 2537–2546 . https://doi.org/10.1021/acschembio.1c00611
Funding Information: We would like to thank A. Löfhjelm and L. Saari for excellent technical assistance. This work was supported by a Sigrid Jusélius Foundation grant to H.K. and the Academy of Finland funding (321809) to T.S. We would also like to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48dab7b1e75d58c8c8668582248387f2
http://urn.fi/URN:NBN:fi:jyu-202110205299
http://urn.fi/URN:NBN:fi:jyu-202110205299
Autor:
Thomas Kryza, Ute Reuning, Tobias Dreyer, Marina Pajic, Viktor Magdolen, Yaowu He, Julia Yin, Juha Rantala, Edward W. Tate, Hannu Koistinen, Scott Lovell, Brittney S. Harrington, Tashbib Khan, John D. Hooper, Sean Porazinski
Publikováno v:
Nature chemical biology. 17(7)
CUB domain-containing protein 1 (CDCP1) is an oncogenic orphan transmembrane receptor and a promising target for the detection and treatment of cancer. Extracellular proteolysis of CDCP1 by poorly defined mechanisms induces pro-metastatic signaling.
Autor:
Ulf-Håkan Stenman, Johanna Wennervirta, Anne Vakkuri, Anna Lempiäinen, Hannu Koistinen, Kristina Hotakainen, Juhani A Stewart, Riitta Koistinen, Ulla-Stina Salminen
Publikováno v:
Scandinavian journal of clinical and laboratory investigation. 80(8)
The concentrations of several diagnostic markers have been found to increase dramatically in critically ill patients with a severe disturbance of normal physiological homeostasis, without indication of the diseases they are normally associated with.
Autor:
Annukka Pasanen, Anne Dell, Cheuk-Lun Lee, Laura Hautala, Aristotelis Antonopoulos, Mikko Loukovaara, Stuart M. Haslam, Poh-Choo Pang, Hannu Koistinen, William S.B. Yeung, Ralf Bützow, Philip C.N. Chiu
Publikováno v:
Laboratory Investigation; a Journal of Technical Methods and Pathology
Glycodelin is a major glycoprotein expressed in reproductive tissues, like secretory and decidualized endometrium. It has several reproduction related functions that are dependent on specific glycosylation, but it has also been found to drive differe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00d5a923d6d3b4264859bbbd3b6c2389
http://hdl.handle.net/10044/1/78020
http://hdl.handle.net/10044/1/78020
Autor:
Jian Wu, Markku Seppälä, Kungfeng Bai, Philip C.N. Chiu, Kai-Fai Lee, Ernest Hung Yu Ng, William S.B. Yeung, Hannu Koistinen, Madhavi Vijayan, Cheuk-Lun Lee, Vera H.H. Wong, Xia Wang
Publikováno v:
Journal of Cell Science.
Decidual macrophages constitute 20-30% of the total leukocytes in the uterus of pregnant women, regulating the maternal immune tolerance and placenta development. Abnormal number or activities of decidual macrophages (dMs) are associated with fetal l
Autor:
Michael Jeltsch, Khushbu Rauniyar, Kenny Mattonet, Ulf-Håkan Stenman, Hannu Koistinen, Ewa Chronowska, Sawan Kumar Jha, Eunice Wairimu Maina, Kari Alitalo
Publikováno v:
eLife, Vol 8 (2019)
eLife
eLife
Vascular endothelial growth factor-C (VEGF-C) acts primarily on endothelial cells, but also on non-vascular targets, for example in the CNS and immune system. Here we describe a novel, unique VEGF-C form in the human reproductive system produced via
Autor:
Xiaoshuang Xun, Kaja Z. LeWinn, Ulf-Håkan Stenman, Shyamal D. Peddada, Thomas R. Zoeller, Jennifer J. Adibi, Margaret A. Adgent, Carroll Kecia, Frances A. Tylavsky, Hannu Koistinen
Publikováno v:
Journal of the Endocrine Society
It is widely agreed that adequate maternal thyroid hormone is necessary for proper brain development. The role of the fetal placenta in ensuring the production and delivery of thyroid hormone during fetal brain development is less well understood. We