Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Goro Katsuumi"'
Autor:
Ippei Shimizu, Takuya Ozawa, Yohko Yoshida, Goro Katsuumi, Tomoyoshi Soga, Daisuke Izumi, Y Hsiao, Masaaki Nakao, Tohru Minamino, Takayuki Wakasugi, Masayoshi Suda, Yuka Hayashi, Kazuyuki Ozaki, Ryutaro Ikegami, Takeshi Kashimura
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Prognosis of severe heart failure remains poor. Urgent new therapies are required. Some heart failure patients do not respond to established multidisciplinary treatment and are classified as “non-responders”. The outcome is especially poor for no
Autor:
Ippei Shimizu, Yusuke Ota, Sho Okada, Ayako Nagasawa, Masayoshi Suda, Goro Katsuumi, Marcus Fruttiger, Yoshiaki Kubota, Takayuki Wakasugi, Tohru Minamino, Masataka Yokoyama, Ryutaro Ikegami, Masanori Tsuchida, Yuka Hayashi, Yoshio Kobayashi, Yohko Yoshida
Publikováno v:
Journal of Molecular and Cellular Cardiology. 129:105-117
p53 is a guardian of the genome that protects against carcinogenesis. There is accumulating evidence that p53 is activated with aging. Such activation has been reported to contribute to various age-associated pathologies, but its role in vascular dys
Autor:
Ippei Shimizu, Masaaki Nakao, Yuka Hayashi, Goro Katsuumi, Yohko Yoshida, Takayuki Wakasugi, Tohru Minamino, Ryutaro Ikegami, Masayoshi Suda
Publikováno v:
International Heart Journal. 59:837-844
Previous studies have suggested that cellular senescence plays a central role in the progression of pathologic changes in the failing heart. It is well known that the sympathetic nervous system is activated in patients with heart failure, and this ch
Autor:
Goro Katsuumi, Yuka Hayashi, Takayuki Wakasugi, Tohru Minamino, Masayoshi Suda, Yohko Yoshida, Ryutaro Ikegami, Hiromi Kayamori, Ippei Shimizu
Publikováno v:
International Heart Journal. 59:607-613
Vascular cells have a finite lifespan and eventually enter irreversible growth arrest called cellular senescence. We have previously suggested that vascular cell senescence contributes to the pathogenesis of human atherosclerosis. Amlodipine is a mix
Autor:
Nobue Yagihara, Hiroshi Furushima, Goro Katsuumi, Masaomi Chinushi, Yoshifusa Aizawa, Akinori Sato, Daisuke Izumi, Tohru Minamino, Sou Otuki, Kanae Hasegawa, Kenichi Iijima, Hiroshi Watanabe
Publikováno v:
Journal of Electrocardiology. 50:277-281
Background Patients with repetitive ventricular tachyarrhythmias — so-called electrical storm — frequently require antiarrhythmic drugs. Amiodarone is widely used for the treatment of electrical storm but is ineffective in some patients. Therefor
Autor:
Tohru Minamino, Hironori Nakagami, Takayuki Wakasugi, Ryuichi Morishita, Ippei Shimizu, Masaaki Nakao, Masayoshi Suda, Ryutaro Ikegami, Yohko Yoshida, Yuka Hayashi, Goro Katsuumi
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-7 (2019)
Scientific Reports
Scientific Reports
We previously demonstrated that cellular aging signals upregulated a secreted class 3 semaphorin E (Sema3E) and its receptor plexinD1 in the adipose tissue of a murine model of dietary obesity and that Sema3E was a chemoattractant, mediating its biol
Autor:
Tohru Minamino, Kazufumi Nakamura, Goro Katsuumi, Takayuki Wakasugi, Tomoyoshi Soga, Hiroshi Ito, Yohko Yoshida, Yuka Hayashi, Masayoshi Suda, Ippei Shimizu, Masaaki Nakao, Takashi Nojiri, Makoto Hoyano, Takeshi Kashimura, Ryutaro Ikegami
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0212889 (2019)
PLoS ONE
PLoS ONE
Pulmonary arterial hypertension (PAH) is characterized by remodeling and narrowing of the pulmonary arteries, which lead to elevation of right ventricular pressure, heart failure, and death. Proliferation of pulmonary artery smooth muscle cells (PASM
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 5 (2018)
Frontiers in Cardiovascular Medicine
Frontiers in Cardiovascular Medicine
In mammals, aging is associated with accumulation of senescent cells. Stresses such as telomere shortening and reactive oxygen species induce “cellular senescence”, which is characterized by growth arrest and alteration of the gene expression pro
Autor:
Yasuhiko Minokoshi, Ippei Shimizu, Takeshi Sato, Ji Li, Eiichi Hinoi, Masayoshi Suda, Takayuki Wakasugi, Shiki Okamoto, Søren Nielsen, Ryutaro Ikegami, Goro Katsuumi, Camilla Scheele, Yuka Hayashi, Tomoyoshi Soga, Tohru Minamino, Yohko Yoshida, Naja Z. Jespersen
Publikováno v:
Cell Reports, Vol 24, Iss 11, Pp 2827-2837.e5 (2018)
Ikegami, R, Shimizu, I, Sato, T, Yoshida, Y, Hayashi, Y, Suda, M, Katsuumi, G, Li, J, Wakasugi, T, Minokoshi, Y, Okamoto, S, Hinoi, E, Nielsen, S, Jespersen, N Z, Scheele, C, Soga, T & Minamino, T 2018, ' Gamma-Aminobutyric Acid Signaling in Brown Adipose Tissue Promotes Systemic Metabolic Derangement in Obesity ', Cell Reports, vol. 24, no. 11, pp. 2827-2837.e5 . https://doi.org/10.1016/j.celrep.2018.08.024
Ikegami, R, Shimizu, I, Sato, T, Yoshida, Y, Hayashi, Y, Suda, M, Katsuumi, G, Li, J, Wakasugi, T, Minokoshi, Y, Okamoto, S, Hinoi, E, Nielsen, S, Jespersen, N Z, Scheele, C, Soga, T & Minamino, T 2018, ' Gamma-Aminobutyric Acid Signaling in Brown Adipose Tissue Promotes Systemic Metabolic Derangement in Obesity ', Cell Reports, vol. 24, no. 11, pp. 2827-2837.e5 . https://doi.org/10.1016/j.celrep.2018.08.024
Summary: Brown adipose tissue (BAT) is a metabolically active organ that contributes to the maintenance of systemic metabolism. The sympathetic nervous system plays important roles in the homeostasis of BAT and promotes its browning and activation. H
Autor:
Tohru Minamino, Yohko Yoshida, Goro Katsuumi, Yuka Hayashi, Masayoshi Suda, Ryo Furuuchi, Masaaki Nakao, Takayuki Wakasugi, Ryutaro Ikegami, Ippei Shimizu
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 8, p e0202051 (2018)
PLoS ONE, Vol 13, Iss 8, p e0202051 (2018)
Endothelial cells have an important role in maintaining vascular homeostasis. Age-related disorders (including obesity, diabetes, and hypertension) or aging per se induce endothelial dysfunction that predisposes to the development of atherosclerosis.