Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Ebbe Boedtkjer"'
Autor:
Jeppe Olsen, Vladimir V. Matchkov, Mads V. Sorensen, Ebbe Boedtkjer, Peder Berg, Vibeke Secher Dam, Samuel L Svendsen, Jens Leipziger
Publikováno v:
Olsen, J S, Svendsen, S L S C, Berg, P, Dam, V S, Sørensen, M V, Matchkov, V, Leipziger, J G & Boedtkjer, E 2021, ' NBCn1 increases NH 4 + reabsorption across thick ascending limbs, the capacity for urinary NH 4 + excretion, and early recovery from metabolic acidosis ', Journal of the American Society of Nephrology, vol. 32, no. 4, pp. 852-865 . https://doi.org/10.1681/ASN.2019060613
BACKGROUND: The electroneutral Na +/HCO 3 - cotransporter NBCn1 (Slc4a7) is expressed in basolateral membranes of renal medullary thick ascending limbs (mTALs). However, direct evidence that NBCn1 contributes to acid-base handling in mTALs, urinary n
Autor:
Ebbe Boedtkjer
Publikováno v:
Boedtkjer, E 2019, ' Na +,HCO 3 – cotransporter NBCn1 accelerates breast carcinogenesis ', Cancer and Metastasis Reviews, vol. 38, no. 1-2, pp. 165-178 . https://doi.org/10.1007/s10555-019-09784-7
Cell metabolism increases during carcinogenesis. Yet, intracellular pH in solid cancer tissue is typically maintained equal to or above that of normal tissue. This is achieved through accelerated cellular acid extrusion that compensates for the enhan
Autor:
Christian Staehr, Kristoffer B Hansen, Palle Duun Rohde, Sukhan Kim, Mette Nyegaard, Vladimir V. Matchkov, Ebbe Boedtkjer, Casper Homilius
Publikováno v:
Berg-Hansen, K, Staehr, C, Rohde, P D, Homilius, C, Kim, S, Nyegaard, M, Matchkov, V & Boedtkjer, E 2020, ' PTPRG is an ischemia risk locus essential for HCO 3--dependent regulation of endothelial function and tissue perfusion ', eLife, vol. 9, e57553 . https://doi.org/10.7554/eLife.57553
eLife, Vol 9 (2020)
Berg-Hansen, K, Staehr, C, Rohde, P D, Homilius, C, Kim, S, Nyegaard, M, Matchkov, V & Boedtkjer, E 2020, ' PTPRG is an ischemia risk locus essential for HCO3--dependent regulation of endothelial function and tissue perfusion ', eLife, vol. 9, e57553, pp. 1-46 . https://doi.org/10.7554/eLife.57553
eLife
eLife, Vol 9 (2020)
Berg-Hansen, K, Staehr, C, Rohde, P D, Homilius, C, Kim, S, Nyegaard, M, Matchkov, V & Boedtkjer, E 2020, ' PTPRG is an ischemia risk locus essential for HCO3--dependent regulation of endothelial function and tissue perfusion ', eLife, vol. 9, e57553, pp. 1-46 . https://doi.org/10.7554/eLife.57553
eLife
Acid-base conditions modify artery tone and tissue perfusion but the involved vascular-sensing mechanisms and disease consequences remain unclear. We experimentally investigated transgenic mice and performed genetic studies in a UK-based human cohort
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac4a684621091b36022b92e9daab5a4b
https://pure.au.dk/portal/da/publications/ptprg-is-an-ischemia-risk-locus-essential-for-hco3dependent-regulation-of-endothelial-function-and-tissue-perfusion(fb87f373-66e5-48e8-bfd9-d41e9eeb1a13).html
https://pure.au.dk/portal/da/publications/ptprg-is-an-ischemia-risk-locus-essential-for-hco3dependent-regulation-of-endothelial-function-and-tissue-perfusion(fb87f373-66e5-48e8-bfd9-d41e9eeb1a13).html
Autor:
Vibeke Secher Dam, Ebbe Boedtkjer, Donald J. Noble, Sandra M. Garraway, Seongho Bae, Christian Aalkjaer, Kristian Beedholm, Inyeong Choi
Publikováno v:
Choi, I, Beedholm, K, Dam, V S, Bae, S-H, Noble, D J, Garraway, S M, Aalkjær, C & Boedtkjer, E 2021, ' Sodium bicarbonate cotransporter NBCn1/Slc4a7 affects locomotor activity and hearing in mice ', Behavioural Brain Research, vol. 401, 113065 . https://doi.org/10.1016/j.bbr.2020.113065
Despite a widespread expression pattern in the central nervous system, the role of the sodium bicarbonate cotransporter NBCn1/Slc4a7 has not been investigated for locomotor activity, emotion and cognition. Here, we addressed the behavioral consequenc
Autor:
Ebbe Boedtkjer, Ninna C. S. Voss, Bent Honoré, Pernille Vahl, Thomas Dreyer, Mikkel B. Henningsen
Publikováno v:
Cancers, Vol 12, Iss 891, p 891 (2020)
Voss, N C S, Dreyer, T K, Henningsen, M B, Vahl, P, Honoré, B & Boedtkjer, E 2020, ' Targeting the acidic tumor microenvironment: Unexpected pro-neoplastic effects of oral NaHCO3 therapy in murine breast tissue ', Cancers, vol. 12, no. 4, 891 . https://doi.org/10.3390/cancers12040891
Cancers
Volume 12
Issue 4
Voss, N C S, Dreyer, T K, Henningsen, M B, Vahl, P, Honoré, B & Boedtkjer, E 2020, ' Targeting the acidic tumor microenvironment: Unexpected pro-neoplastic effects of oral NaHCO3 therapy in murine breast tissue ', Cancers, vol. 12, no. 4, 891 . https://doi.org/10.3390/cancers12040891
Cancers
Volume 12
Issue 4
The acidic tumor microenvironment modifies malignant cell behavior. Here, we study consequences of the microenvironment in breast carcinomas. Beginning at carcinogen-based breast cancer induction, we supply either regular or NaHCO3-containing drinkin
Autor:
Ebbe Boedtkjer, Stine F. Pedersen
Publikováno v:
Boedtkjer, E & Pedersen, S F 2020, ' The Acidic Tumor Microenvironment as a Driver of Cancer ', Annual Review of Physiology, vol. 82, pp. 103-126 . https://doi.org/10.1146/annurev-physiol-021119-034627
Acidic metabolic waste products accumulate in the tumor microenvironment because of high metabolic activity and insufficient perfusion. In tumors, the acidity of the interstitial space and the relatively well-maintained intracellular pH influence can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bbcc79e98e38b2800cef91009fc05fa
https://pure.au.dk/portal/da/publications/the-acidic-tumor-microenvironment-as-a-driver-of-cancer(b1ac3f58-7869-4652-b310-82300c0303f4).html
https://pure.au.dk/portal/da/publications/the-acidic-tumor-microenvironment-as-a-driver-of-cancer(b1ac3f58-7869-4652-b310-82300c0303f4).html
Autor:
Anne Sofie Froelunde, Ebbe Boedtkjer, Sukhan Kim, Kristoffer B Hansen, Nicolai Jessen, Marit Edna Ohlenbusch
Publikováno v:
Breast Cancer Research, Vol 20, Iss 1, Pp 1-12 (2018)
Breast Cancer Research : BCR
Frølunde, A S, Ohlenbusch, M E, Berg-Hansen, K, Jessen, N, Kim, S & Boedtkjer, E 2018, ' Murine breast cancer feed arteries are thin-walled with reduced α 1A-adrenoceptor expression and attenuated sympathetic vasocontraction ', Breast Cancer Research, vol. 20, 20 . https://doi.org/10.1186/s13058-018-0952-8
Breast Cancer Research : BCR
Frølunde, A S, Ohlenbusch, M E, Berg-Hansen, K, Jessen, N, Kim, S & Boedtkjer, E 2018, ' Murine breast cancer feed arteries are thin-walled with reduced α 1A-adrenoceptor expression and attenuated sympathetic vasocontraction ', Breast Cancer Research, vol. 20, 20 . https://doi.org/10.1186/s13058-018-0952-8
Background Perfusion of breast cancer tissue limits oxygen availability and metabolism but angiogenesis inhibitors have hitherto been unsuccessful for breast cancer therapy. In order to identify abnormalities and possible therapeutic targets in matur
Autor:
Stine F. Pedersen, Eva Kjer Oernbo, Marie Kveiborg, Jacob Samsøe-Petersen, Ebbe Boedtkjer, Anne Poder Andersen, José M.A. Moreira
Publikováno v:
International Journal of Cancer. 142:2529-2542
High metabolic and proliferative rates in cancer cells lead to production of large amounts of H+ and CO2 , and as a result, net acid extruding transporters are essential for the function and survival of cancer cells. We assessed protein expression of
Publikováno v:
Rasmussen, J K & Boedtkjer, E 2018, ' Carbonic anhydrase inhibitors modify intracellular pH transients and contractions of rat middle cerebral arteries during CO 2 /HCO 3 – fluctuations ', Journal of Cerebral Blood Flow and Metabolism, vol. 38, no. 3, pp. 492-505 .
The CO2/HCO3– buffer minimizes pH changes in response to acid–base loads, HCO3– provides substrate for Na+,HCO3–-cotransporters and Cl–/HCO3–-exchangers, and H+ and HCO3– modify vasomotor responses during acid–base disturbances. We sh
Publikováno v:
Physiological Reports, Vol 7, Iss 8, Pp n/a-n/a (2019)
Møller, A L, Hjortdal, V E, Bødtkjer, D B & Boedtkjer, E 2019, ' Acidosis inhibits rhythmic contractions of human thoracic ducts ', Physiological Reports, vol. 7, no. 8, e14074 . https://doi.org/10.14814/phy2.14074
Physiological Reports
Møller, A L, Hjortdal, V E, Bødtkjer, D B & Boedtkjer, E 2019, ' Acidosis inhibits rhythmic contractions of human thoracic ducts ', Physiological Reports, vol. 7, no. 8, e14074 . https://doi.org/10.14814/phy2.14074
Physiological Reports
Lymph vessels counteract edema by transporting interstitial fluid from peripheral tissues to the large veins and serve as conduits for immune cells, cancer cells, and pathogens. Because edema during inflammation and malignancies is frequently associa