Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Davide Trotti"'
Publikováno v:
EMBO J
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder whose exact causative mechanisms are still under intense investigation. Several lines of evidence suggest that the anatomical and temporal propagation of pathological protein s
Autor:
Katelyn Russell, Ashley Boehringer, Dieter Edbauer, Kevin McAvoy, Brigid K. Jensen, Thomas Westergard, Bridget M. Curran, Le Ma, Martin H Schuldi, Piera Pasinelli, Xinmei Wen, Karthik Krishnamurthy, Aaron R. Haeusler, Davide Trotti
Publikováno v:
EMBO molecular medicine 12(5), e10722 (2020). doi:10.15252/emmm.201910722
EMBO Molecular Medicine
EMBO Molecular Medicine, Vol 12, Iss 5, Pp n/a-n/a (2020)
EMBO Molecular Medicine
EMBO Molecular Medicine, Vol 12, Iss 5, Pp n/a-n/a (2020)
The most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is an intronic hexanucleotide repeat expansion in the C9orf72 gene. In disease, RNA transcripts containing this expanded region undergo repeat‐associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73196be2a6ddf0e1abed144a6614902a
Publikováno v:
Glia
Mutations in fused in sarcoma (FUS) are linked to amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease affecting both upper and lower motor neurons. While it is established that astrocytes contribute to the death of motor neurons in
Autor:
Silvia Bonanno, Loqman A. Mohamed, Piera Pasinelli, Davide Trotti, Shashirekha S. Markandaiah
Publikováno v:
The AAPS Journal. 19:1600-1614
The blood–brain barrier (BBB) is essential for proper neuronal function, homeostasis, and protection of the central nervous system (CNS) microenvironment from blood-borne pathogens and neurotoxins. The BBB is also an impediment for CNS penetration
Publikováno v:
Neuroscience Letters. 636:16-26
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two apparently distinct neurodegenerative diseases, the former characterized by selective loss of motor neurons in the brain and spinal cord and the latter characterized by sel
Autor:
Elizabeth Kropf, Jingli Cai, Brigid K. Jensen, Piera Pasinelli, Thomas Westergard, Lorraine Iacovitti, Davide Trotti, Xinmei Wen
Publikováno v:
Cell Reports, Vol 17, Iss 3, Pp 645-652 (2016)
SummaryAberrant hexanucleotide repeat expansions in C9orf72 are the most common genetic change underlying amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). RNA transcripts containing these expansions undergo repeat-associated non
Autor:
Piera Pasinelli, Silvia Bonanno, Davide Trotti, Loqman A. Mohamed, Shashirekha S. Markandaiah
Publikováno v:
Exp Neurol
In amyotrophic lateral sclerosis (ALS), upregulation in expression and activity of the ABC transporter P-glycoprotein (P-gp) driven by disease advancement progressively reduces CNS penetration and efficacy of the ALS drug, riluzole. Post-mortem spina
Autor:
Jean Philippe Richard, Kevin McAvoy, Shashirekha S. Markandaiah, Mark Sarlo, Piera Pasinelli, Hisham Qosa, Nicholas J. Maragakis, Davide Trotti, Michael R. Jablonski, Jessica Lichter
Publikováno v:
Glia. 64:1298-1313
The efficacy of drugs targeting the CNS is influenced by their limited brain access, which can lead to complete pharmacoresistance. Recently a tissue-specific and selective upregulation of the multidrug efflux transporter ABCB1 or P-glycoprotein (P-g
Autor:
Gabriel R. Linares, Justin K. Ichida, Yingxiao Shi, Brandon B Ge, Yichen Li, Jacob Komberg, R. Jeroen Pasterkamp, Davide Trotti, Valerie Hennes, Leonard H. van den Berg, Nicole Koutsodendris, Jason A. Chen, Kaitlin P. Sandor, Vamshidhar R. Vangoor, Louise Menendez, Amy R. Nelson, Michael E. Ward, Tze-Yuan Cheng, Yaoming Wang, Phillip E. Woolwine, Wen-Hsuan Chang, Ketharini Senthilkumar, Kim A. Staats, Mickey Huang, Carina Seah, Alice Zhang, Chris Grunseich, Esther Y. Son, Eric Hendricks, Michael J. Cowan, Paul R. August, Kassandra Kisler, Shih Jong J. Lee, Marcelo P. Coba, Shu Ting Hung, Shaoyu Lin, Brent Wilkinson, N. Wisniewski, Berislav V. Zlokovic, Tohru Sugawara, T. Grant Belgard, Victor Hanson-Smith, Xinmei Wen
Publikováno v:
Nature Medicine, 24(3), 313. Nature Publishing Group
An intronic GGGGCC repeat expansion in C9ORF72 is the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), but the pathogenic mechanism of this repeat remains unclear. Using human induced motor neurons (iMNs), w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a7b18c3fd3677e0457e409e74f97ed0
https://dspace.library.uu.nl/handle/1874/364200
https://dspace.library.uu.nl/handle/1874/364200
Autor:
Oded Behar, Ariel Ionescu, Miguel Weil, Shane Wald-Altman, Sahar Sweetat, Shani Inbar, Davide Trotti, Eran Perlson, Tal Gradus, Roy Maimon, Avichai Bonnie
Publikováno v:
The Journal of Neuroscience
Axon degeneration and disruption of neuromuscular junctions (NMJs) are key events in amyotrophic lateral sclerosis (ALS) pathology. Although the disease's etiology is not fully understood, it is thought to involve a non–cell-autonomous mechanism an