Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Cima, Michael J."'
Autor:
Ann M. Graybiel, Michael J. Cima, Khalil B. Ramadi, Kevin C. Spencer, Jay C. Sy, Robert Langer
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
Nature
Nature
Glial scar is a significant barrier to neural implant function. Micromotion between the implant and tissue is suspected to be a key driver of glial scar formation around neural implants. This study explores the ability of soft hydrogel coatings to mo
Autor:
Keyue Shen, Michael J. Cima, Jungwoo Lee, Arjun K. Manrai, Biju Parekkadan, Martin L. Yarmush, Aaron Gabow, Joshua Yarmush, Yunxin Jiao, Jack M. Milwid, Jessica S Elman, Anne L. Fletcher, Matthew D. Li
Publikováno v:
Elsevier
The secreted proteins from a cell constitute a natural biologic library that can offer significant insight into human health and disease. Discovering new secreted proteins from cells is bounded by the limitations of traditional separation and detecti
Autor:
Matthew Whitman, Joyce T. O’Connell, Mihir B. Doshi, Patrick Bhola, Li Tan, Jinhua Wang, Robert Langer, Anthony Letai, Oliver Jonas, Young Jin Ham, John G. Doench, Yaara Zwang, William C. Hahn, Casandra Chen, David E. Root, Nathanael S. Gray, Federica Piccioni, Mikael L. Rinne, Hai-Tsang Huang, Michael J. Cima
Publikováno v:
eLife
eLife, Vol 6 (2017)
eLife, Vol 6 (2017)
Activating mutations involving the PI3K pathway occur frequently in human cancers. However, PI3K inhibitors primarily induce cell cycle arrest, leaving a significant reservoir of tumor cells that may acquire or exhibit resistance. We searched for gen
Autor:
Joshua D. Rabinowitz, Alex Lammers, Alba Luengo, Kendall J. Condon, Jongyoon Han, Dafna Bar-Sagi, Jeffrey Wyckoff, Michael J. Cima, Robert Langer, Katherine A Kellersberger, Christopher R. Chin, Brian K Stall, Shawn M. Davidson, Jared R. Mayers, Mark A. Keibler, Han Wei Hou, Oliver Jonas, Matthew Whitman, Gregory Stephanopoulos, Amanda M. Del Rosario, Matthew G. Vander Heiden
Publikováno v:
PMC
Mammalian tissues rely on a variety of nutrients to support their physiological functions. It is known that altered metabolism is involved in the pathogenesis of cancer, but which nutrients support the inappropriate growth of intact malignant tumors
Autor:
Brian D. Crompton, Jesse S. Boehm, Levi A. Garraway, Paul Van Hummelen, Alykhan F. Shamji, Sara Howell, Craig M. Bielski, Gregory V. Kryukov, Stephanie C. Meyer, William C. Hahn, Yuen-Yi Tseng, Paula Keskula, Coyin Oh, Oliver Jonas, Carlos Rodriguez-Galindo, Shubhroz Gill, Robert Langer, Francisca Vazquez, Mihir B. Doshi, Paul A. Clemons, Alanna J. Church, Andrew L. Hong, Stuart L. Schreiber, Alma Imamovic, Charles W. M. Roberts, Katherine A. Janeway, Michael J. Cima, Kimberly Stegmaier, Aviad Tsherniak, David E. Root, Glenn S. Cowley, Jaime H. Cheah, Bryan D. Kynnap
Publikováno v:
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Nature
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Nature
Identifying therapeutic targets in rare cancers remains challenging due to the paucity of established models to perform preclinical studies. As a proof-of-concept, we developed a patient-derived cancer cell line, CLF-PED-015-T, from a paediatric pati
Autor:
John M. Lamar, Madeleine J. Oudin, Douglas A. Lauffenburger, Liliane C. Broye, Patricia J. Keely, Michael J. Cima, Sreeja B. Asokan, Oliver Jonas, Robert Langer, Charles A. Whittaker, Kari B. Wisinski, Duanduan Ma, Jeffrey Wyckoff, James E. Bear, Tatsiana Kosciuk, Bruna C. Guido, Frank B. Gertler, Richard O. Hynes, Daisy N. Riquelme
Publikováno v:
Cancer Discovery
Fibronectin (FN) is a major component of the tumor microenvironment, but its role in promoting metastasis is incompletely understood. Here we show that FN gradients elicit directional movement of breast cancer cells, in vitro and in vivo. Haptotaxis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::295b18623105cc55ad96df21f4a4100c