Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Christine M. Dejea"'
Autor:
Ye Yang, Raad Z. Gharaibeh, Payam Fathi, Shaoguang Wu, Liam Chung, Anthony A. Fodor, Sarah Tomkovich, Sepideh Besharati, Marcus Mühlbauer, James R. White, Jillian L. Pope, Cynthia L. Sears, Ernesto Perez-Chanona, Drew M. Pardoll, Julia L. Drewes, Kathryn Winglee, Xinqun Wu, Robert A. Anders, Christian Jobin, Franck Housseau, Christine M. Dejea, Hao Wang, Xiaolun Sun, Josee Gauthier, Xiuli Liu, Hua Ding
Publikováno v:
Journal of Clinical Investigation. 129:1699-1712
Mucus-invasive bacterial biofilms are identified on the colon mucosa of approximately 50% of colorectal cancer (CRC) patients and approximately 13% of healthy subjects. Here, we test the hypothesis that human colon biofilms comprise microbial communi
Autor:
Ye Yang, Raad Z. Gharaibeh, Thomas D. Schmittgen, Anthony A. Fodor, Jinmai Jiang, Cynthia L. Sears, Kathryn Winglee, Christine M. Dejea, Rachel C. Newsome, Josee Gauthier, Christian Jobin, Jillian L. Pope, Sarah Tomkovich
Publikováno v:
mSystems
mSystems, Vol 5, Iss 1 (2020)
mSystems, Vol 5, Iss 1, p e00451-19 (2020)
mSystems, Vol 5, Iss 1 (2020)
mSystems, Vol 5, Iss 1, p e00451-19 (2020)
Bacteria and bacterial biofilms have been implicated in colorectal cancer (CRC), but it is still unclear what genes these microbial communities express and how they influence the host. MicroRNAs regulate host gene expression and have been explored as
Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria
Autor:
John M. Craig, Shaoguang Wu, Christina E. DeStefano Shields, Xinqun Wu, Robert A. Anders, Christine M. Dejea, Rahwa Taddese, Hao Wang, Abby L. Geis, David L. Huso, Drew M. Pardoll, Francis M. Giardiello, Elizabeth C. Wick, Annemarie Boleij, Franck Housseau, Payam Fathi, Elizabeth M. Hechenbleikner, Cynthia L. Sears
Publikováno v:
Science, 359, 6375, pp. 592-597
Science, 359, 592-597
Science, 359, 592-597
Biofilms provide refuge for cancerous bacteria Familial adenomatous polyposis (FAP) causes benign polyps along the colon. If left untreated, FAP leads to a high incidence of colon cancer. To understand how polyps influence tumor formation, Dejea et a
Autor:
Christine M. Dejea, Cynthia L. Sears
Publikováno v:
Gut Microbes. 7:54-57
It is now widely recognized that a range of human diseases, including obesity, cancer and inflammatory bowel disease, is strongly linked to the microbiota. For decades, the microbiota has been proposed to contribute to the pathogenesis of colon cance
Autor:
Mun Fai Loke, Jamuna Vadivelu, James R. White, Cynthia L. Sears, Hoong Yin Chong, Thevambiga Iyadorai, Sandip Kumar, Han Ming Gan, Khean-Lee Goh, Julia L. Drewes, Payam Fathi, Emmanuel F. Mongodin, April Camilla Roslani, Jane W. Wanyiri, Elizabeth C. Wick, Christine M. Dejea, Kumar Thulasi
Publikováno v:
npj Biofilms and Microbiomes, Vol 3, Iss 1, Pp 1-12 (2017)
NPJ Biofilms and Microbiomes
NPJ Biofilms and Microbiomes
Colorectal cancer (CRC) remains the third most common cancer worldwide, with a growing incidence among young adults. Multiple studies have presented associations between the gut microbiome and CRC, suggesting a link with cancer risk. Although CRC mic
Autor:
Hongni Fan, Cynthia L. Sears, Christine M. Dejea, Shaoguang Wu, Benjamin B. Finard, Abby L. Geis, Xinqun Wu, Christina E. DeStefano Shields, David L. Huso, Elizabeth C. Wick, Kai Fu, June L. Chan, Ada J. Tam, Sara W. Van Meerbeke, Liam Chung, Fengyi Wan, Florencia McAllister, Erik Thiele Orberg, Payam Fathi, Andriana Lebid, Franck Housseau, Drew M. Pardoll, Jie Chen, Paul Metz, Sudipto Ganguly
Publikováno v:
Cell host & microbe, vol 23, iss 2
Summary Pro-carcinogenic bacteria have the potential to initiate and/or promote colon cancer, in part via immune mechanisms that are incompletely understood. Using Apc Min mice colonized with the human pathobiont enterotoxigenic Bacteroides fragilis
Autor:
Shaoguang Wu, Cynthia L. Sears, Franck Housseau, E. Thiele Orberg, Payam Fathi, Ada Tam, Sudipto Ganguly, Hongni Fan, Drew M. Pardoll, Juan Fu, Xinqun Wu, C E Destefano Shields, Benjamin B. Finard, Christine M. Dejea, Liam Chung
Publikováno v:
Mucosal immunology
Enterotoxigenic Bacteroides fragilis (ETBF), a human commensal and candidate pathogen in colorectal cancer (CRC), is a potent initiator of interleukin-17 (IL-17)-dependent colon tumorigenesis in MinApc+/- mice. We examined the role of IL-17 and ETBF
Autor:
Britta Rauck, Jeffrey D. Rothstein, Christine M. Dejea, Andrea C. Pardo, Nicholas J. Maragakis, Mahendra S. Rao, Angelo C. Lepore
Publikováno v:
Nature neuroscience
Cellular abnormalities in amyotrophic lateral sclerosis (ALS) are not limited to motor neurons. Astrocyte dysfunction also occurs in human ALS and transgenic rodents expressing mutant human SOD1 protein (SOD1(G93A)). Here we investigated focal enrich