Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Asla Pitkänen"'
Publikováno v:
Brain Structure & Function
Ventricular enlargement is one long-term consequence of a traumatic brain injury, and a risk factor for memory disorders and epilepsy. One underlying mechanisms of the chronic ventricular enlargement is disturbed cerebrospinal-fluid secretion or abso
Autor:
Olli Gröhn, Niina Lapinlampi, Pedro Andrade, Alejandra Sierra, Eppu Manninen, Jussi Tohka, Tomi Paananen, Karthik Chary, Asla Pitkänen
Publikováno v:
Epilepsia. 62:1852-1864
OBJECTIVE To identify magnetic resonance imaging (MRI) biomarkers for post-traumatic epilepsy. METHODS The EPITARGET (Targets and biomarkers for antiepileptogenesis, epitarget.eu) animal cohort completing T2 relaxation and diffusion tensor MRI follow
Autor:
Tomi Paananen, Asla Pitkänen, Karthik Chary, Niina Lapinlampi, Alejandra Sierra, Eppu Manninen, Jussi Tohka, Pedro Andrade, Olli Gröhn
Publikováno v:
Journal of Neurotrauma. 37:2580-2594
Prognostic biomarkers for post-injury outcome are necessary for the development of neuroprotective and antiepileptogenic treatments for traumatic brain injury (TBI). We hypothesized that T2 relaxat...
Publikováno v:
Neuroscience. 433:21-35
Mechanisms initiated by traumatic brain injury (TBI), leading to the development of progressive secondary injury are poorly understood. MicroRNAs (miRNAs) have a proposed role in orchestrating the post-injury aftermath as a single miRNA can control t
Publikováno v:
Neuroinformatics
Disabilities resulting from traumatic brain injury (TBI) strongly correlate with the cytoarchitectonic part of the brain damaged, lesion area, and type of lesion. We developed a Web application to estimate the location of the lesion on mouse cerebral
Autor:
David J. Poulsen, Jenni Kyyriäinen, Kaitlynn Donahue, Kathryn Toffolo, Ferdinand Schweser, Austin Poulsen, Asla Pitkänen, Benett Levy, Marilena Preda
Publikováno v:
Neuroimage
A key event in the pathophysiology of traumatic brain injury (TBI) is the influx of substantial amounts of Ca2+ into neurons, particularly in the thalamus. Detection of this calcium influx in vivo would provide a window into the biochemical mechanism
Autor:
Merab Kokaia, Janet Mifsud, Sergiusz Jozwiak, Michele Simonato, David C. Henshall, Asla Pitkänen, J. Helen Cross, Renzo Guerrini, Sanjay M. Sisodiya
Publikováno v:
Epilepsia. 60:1281-1292
Seven large European Union (EU)-funded epilepsy-related research projects joined forces in May 2018 in Brussels, Belgium, in a unique community building event-the epiXchange conference. During this conference, 170 investigators from the projects DESI
Autor:
Arthur W. Toga, Niina Lapinlampi, Adebayo Braimah, Paul M. Vespa, Dominique Duncan, Asla Pitkänen
Publikováno v:
Neurobiology of Disease, Vol 123, Iss, Pp 127-136 (2019)
We describe the infrastructure and functionality for a centralized preclinical and clinical data repository and analytic platform to support importing heterogeneous multi-modal data, automatically and manually linking data across modalities and sites
Autor:
Xavier Ekolle Ndode-Ekane, Heikki Tanila, Anssi Lipponen, Laura Oliva Pérez, Jenni Kyyriäinen, Asla Pitkänen, Hennariikka Koivisto, Tamuna Bolkvadze
Publikováno v:
Epilepsy Research. 151:67-74
Extracellular proteolysis initiated by the binding of urokinase-type plasminogen activator (uPA) to its receptor (uPAR) regulates the development of inhibitory neuronal circuits in the cerebral cortex and tissue remodeling after epileptogenic brain i
Autor:
Roxanne Aniceto, Denes V. Agoston, Gregory Smith, Pedro Andrade de Abreu, Terence J. O'Brien, Matthew R. Hudson, Shalini Das Gupta, Pablo M. Casillas-Espinosa, Alaa Kamnaksh, Xavier Ekolle Ndode-Ekane, Sandy R. Shultz, Rhys D. Brady, Riikka Immonen, Jesse Mccullough, Noora Puhakka, Idrish Ali, Asla Pitkänen, Richard J. Staba, César Emmanuel Santana-Gómez, Nigel C. Jones
Publikováno v:
Epilepsy Research. 149:92-101
The Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx) is an international, multicenter, multidisciplinary study aimed at preventing epileptogenesis (EpiBioS4Rx: https://epibios.loni.usc.edu/). One of the study's major objective