Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Andrée E. Gravel"'
Autor:
Dror E. Warschawski, Alexandre A. Arnold, Matthieu Fillion, Isabelle Marcotte, Michèle Auger, Andrée E. Gravel
Publikováno v:
Biochimica et Biophysica Acta:Biomembranes
Biochimica et Biophysica Acta:Biomembranes, Elsevier, 2020, 1862 (10), pp.183379. ⟨10.1016/j.bbamem.2020.183379⟩
Biochimica et Biophysica Acta:Biomembranes, Elsevier, 2020, 1862 (10), pp.183379. ⟨10.1016/j.bbamem.2020.183379⟩
International audience; We present a new membrane mimetic system using a membrane softening detergent commonly known as Tween 80 (TW80), to form oriented systems for solid-state NMR applications. TW80 is a fatty acid ester (oleate) of sorbitan polyet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3699c74f93929ec10840dc406bc55617
https://hal.archives-ouvertes.fr/hal-02861563
https://hal.archives-ouvertes.fr/hal-02861563
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1858:2959-2964
Nuclear magnetic resonance (NMR) is commonly used to probe the effect of antimicrobial agents on bacterial membranes using model membrane systems. Ideally, considering the complexity of membranes, the interaction of molecules with membranes should be
Autor:
Alexandre A. Arnold, Isabelle Marcotte, Chai Ann Ng, Matthew D. Perry, Jamie I. Vandenberg, Andrée E. Gravel
Slow deactivation of Kv11.1 channels is critical for its function in the heart. The S4-S5 linker, which joins the voltage sensor and pore domains, plays a critical role in this slow deactivation gating. Here, we use NMR spectroscopy to identify the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1328d5a1bdce78764a7fa09f0954d72
https://europepmc.org/articles/PMC5016128/
https://europepmc.org/articles/PMC5016128/
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1798:1651-1662
The human ether-à-go-go related gene (hERG) potassium channels are located in the myocardium cell membrane where they ensure normal cardiac activity. The binding of drugs to this channel, a side effect known as drug-induced (acquired) long QT syndro
Publikováno v:
Biochimica et Biophysica Acta:Biomembranes
Biochimica et Biophysica Acta:Biomembranes, Elsevier, 2013, 1828 (6), pp.1494-1502. ⟨10.1016/j.bbamem.2013.02.012⟩
Biochimica et Biophysica Acta:Biomembranes, Elsevier, 2013, 1828 (6), pp.1494-1502. ⟨10.1016/j.bbamem.2013.02.012⟩
The human ether-a-go-go-related gene (hERG) voltage-gated K(+) channels are located in heart cell membranes and hold a unique selectivity filter (SF) amino acid sequence (SVGFG) as compared to other K(+) channels (TVGYG). The hERG provokes the acquir
Autor:
Alexandre A. Arnold, Étienne Chartrand, Andrée E. Gravel, Maïwenn Beaugrand, Dror E. Warschawski, Isabelle Marcotte
Publikováno v:
Biochimica et Biophysica Acta:Biomembranes
Biochimica et Biophysica Acta:Biomembranes, Elsevier, 2011, 1808 (8), pp.1957-1974. ⟨10.1016/j.bbamem.2011.03.016⟩
Biochimica et Biophysica Acta:Biomembranes, Elsevier, 2011, 1808 (8), pp.1957-1974. ⟨10.1016/j.bbamem.2011.03.016⟩
The native environment of membrane proteins is complex and scientists have felt the need to simplify it to reduce the number of varying parameters. However, experimental problems can also arise from oversimplification which contributes to why membran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cd52181202278863110d597949ed817
https://hal.archives-ouvertes.fr/hal-02567622
https://hal.archives-ouvertes.fr/hal-02567622
Autor:
Sumit Kalsi, Jason C. Young, Christopher D. Johnson, Andrée E. Gravel, Maurits R.R. de Planque, Isabelle Marcotte, Philip T. F. Williamson, J. Neville Wright, Maïwenn Beaugrand
Publikováno v:
Biophysical Journal. (2):137a
The long QT syndrome (LQTS) is a cardiac dysfunction that prolongs the heart repolarisation interval, leading to cardiac arrhythmia or failure. This pathology can be induced by off-target effects of drugs which block the human ether-a-go-go related g
Publikováno v:
Biophysical Journal
Biophysical Journal, Biophysical Society, 2011, 100 (3), pp.602a. ⟨10.1016/j.bpj.2010.12.3468⟩
Biophysical Journal, Biophysical Society, 2011, 100 (3), pp.602a. ⟨10.1016/j.bpj.2010.12.3468⟩
The drug-induced (acquired) long QT syndrome (ALQTS) is a cardiac muscle dysfunction responsible for heart arrhythmia and failure. Virtually all cases of ALQTS are due to the blockage of the heart human ether-a-go-go-related-gene (hERG) potassium cha
Publikováno v:
Biophysical Journal. (2):501a
Tween-80 (TW80) is a fatty acid ester (oleate) of sorbitan polyethoxylate known to be a mild non-ionic surfactant and is commonly used to solubilize membrane proteins. In order to facilitate the structural study of membrane proteins and peptides by n