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pro vyhledávání: ''
Autor:
Maciej Pawłowski, Xavier Bantreil, Natalia Malikowska-Racia, Ryszard Bugno, Joanna Golebiowska, Jean Martinez, Frédéric Lamaty, Séverine Chaumont-Dubel, Gilles Subra, Paweł Zajdel, Grzegorz Satała, Piotr Popik, Katarzyna Grychowska, Andrzej J. Bojarski, Philippe Marin, Szczepan Mogilski, Rafał Kurczab, Agnieszka Nikiforuk, Tomasz Kos
Publikováno v:
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, 2021, 64 (18), pp.13279-13298. ⟨10.1021/acs.jmedchem.1c00224⟩
Journal of Medicinal Chemistry, American Chemical Society, 2021, 64 (18), pp.13279-13298. ⟨10.1021/acs.jmedchem.1c00224⟩
Journal of Medicinal Chemistry, 2021, 64 (18), pp.13279-13298. ⟨10.1021/acs.jmedchem.1c00224⟩
Journal of Medicinal Chemistry, American Chemical Society, 2021, 64 (18), pp.13279-13298. ⟨10.1021/acs.jmedchem.1c00224⟩
International audience; In line with recent clinical trials demonstrating that ondansetron, a 5-HT3 receptor (5-HT3R) antagonist, ameliorates cognitive deficits of schizophrenia and the known procognitive effects of 5-HT6 receptor (5-HT6R) antagonist
Autor:
Tracy M. Josephs, Le Vi Dinh, Aaron DeBono, Karen J. Gregory, Ben Capuano, Katie Leach, Andrew N. Keller
Publikováno v:
ChemMedChem. 16:3451-3462
The calcium-sensing receptor (CaSR) is a clinical target in the treatment of hyperparathyroidism and related diseases. However, clinical use of approved CaSR-targeting drugs such as cinacalcet ( 1 ) is limited due to adverse side effects including hy
Autor:
Lily L. Cao, Prem Kumar, Jiarong Fu, Abdulaziz A. Alzahrani, Demitris Nathanael, Keith L. Brain, Andrew M. Coney, Hayyaf S. Aldossary, Clare J. Ray, Andrew P. Holmes
Publikováno v:
Pflugers Archiv
Carotid body (CB) hyperactivity promotes hypertension in response to chronic intermittent hypoxia (CIH). The plasma concentration of adrenaline is reported to be elevated in CIH and our previous work suggests that adrenaline directly activates the CB
Autor:
Na Liu, Jiaxing Sun, Xin Zhang, Wenxiu Liu, Xue Ding, Xinhua Yin, Yutong Guo, Ningning Kang, Jinyu Chi, Yue Liu
Publikováno v:
Journal of Cellular and Molecular Medicine
The calcium‐sensing receptor (CaSR) is involved in the pathophysiology of many cardiovascular diseases, including myocardial infarction (MI) and hypertension. The role of Calhex231, a specific inhibitor of CaSR, in myocardial fibrosis following MI
Autor:
Tobias Thaler, Elisabeth Kersten, Hannah JÖRIßEN, Chantal Fürstner, Sonja Anlauf, Mark Meininghaus, Kersten Matthias Gericke, Lisa Dietz, Dirk Schneider, Hartmut Beck, Virginia Marossek, Carsten Terjung, Johanna Anlahr, Daniel Meibom, Uwe Münster, Thomas Buyck, Raimund Kast, Kai Lovis, Timo Stellfeld, Guillaume Levilain, Michaela Bairlein, Clemens-Jeremias Von Bühler
Publikováno v:
Journal of Medicinal Chemistry. 63:11639-11662
Idiopathic pulmonary fibrosis (IPF) is a rare and devastating chronic lung disease of unknown etiology. Despite the approved treatment options nintedanib and pirfenidone, the medical need for a safe and well-tolerated antifibrotic treatment of IPF re
Publikováno v:
J Med Chem
The endogenous neuropeptide FF (NPFF) and its two cognate G protein-coupled receptors, Neuropeptide FF Receptors 1 and 2 (NPFFR1 and NPFFR2), represent a relatively new target system for many therapeutic applications including pain regulation, modula
Autor:
Jennifer L. Schmachtenberg, John F. Reed, Randy Torralva, Tracy L. Swanson, William E. Schutzer, Katherine M. Wolfrum, Amy J. Eshleman, Shelley H. Bloom, Aaron Janowsky
Publikováno v:
J Pharmacol Exp Ther
Synthetic opioids, including fentanyl and its analogs, have therapeutic efficacy in analgesia and anesthesia. However, their illicit use in the United States has increased and contributed to the number one cause of death for adults 18–50 years old.
Autor:
Zhihui Chen, Xizhen Xu, Ruolan Dong, Menglu Fu, Yan Yang, Ying Tang, Danli Hu, Ling Tu, Yanjun Zhang
Publikováno v:
Molecular Medicine Reports
Age-related alterations in the renin-angiotensin-aldosterone system (RAAS) have been reported in the cardiovascular system; however, the detailed mechanism of the RAAS component mineralocorticoid receptors (MR) has not been elucidated. The present st
Publikováno v:
Mol Pharmacol
Based on studies using mutations of the µ-opioid receptor (MOR), phosphorylation of multiple sites on the C-terminus has been recognized as a critical step underlying acute desensitization and the development of cellular tolerance. The aim of this s
Publikováno v:
Journal of Cellular and Molecular Medicine
δ‐opioid receptor (DOPr) agonists have analgesic efficacy in chronic pain models but development of tolerance limits their use for long‐term pain management. Although agonist potential for inducing acute analgesic tolerance has been associated w