Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Richard A, Koup"'
Publikováno v:
Methods. 154:118-124
Bispecific (bs) antibodies (Abs, bsAbs) are engineered immunoglobulins that contain two different antigen-binding sites in one molecule. bsAbs can be divided in two molecular formats; the IgG-like and non-IgG like. The structural elements of each for
Autor:
Rachel L. Rutishauser, Peter W. Hunt, Kyle A. Raymond, Daniel C. Douek, Theodore L. Roth, Rafick-Pierre Sekaly, Frederick Hecht, Alexander Marson, Carly E. Starke, Franziska Blaeschke, Steven G. Deeks, Christian Deo T Deguit, Christopher D. Pilcher, Joseph Hiatt, Joseph C. Mudd, Wenxuan Chen, Carolyn P Smullin, Joseph M. McCune, Satish K. Pillai, Melissa R. Krone, Richard A. Koup, Rebecca Hoh, Jeffrey N. Martin, Jason M. Brenchley, Lynn Wang, Rodrigo Matus-Nicodemos
Publikováno v:
JCI Insight
JCI Insight, Vol 6, Iss 3 (2021)
JCI insight, vol 6, iss 3
JCI Insight, Vol 6, Iss 3 (2021)
JCI insight, vol 6, iss 3
Although many HIV cure strategies seek to expand HIV-specific CD8+ T cells to control the virus, all are likely to fail if cellular exhaustion is not prevented. A loss in stem-like memory properties (i.e., the ability to proliferate and generate seco
Publikováno v:
Retrovirology, Vol 15, Iss 1, Pp 1-10 (2018)
Retrovirology
Retrovirology
The induction of HIV-1-specific antibodies that can neutralize a broad number of isolates is a major goal of HIV-1 vaccination strategies. However, to date no candidate HIV-1 vaccine has successfully elicited broadly neutralizing antibodies of suffic
Autor:
Pablo Tebas, Robert F. Siliciano, Mohamed Abdel-Mohsen, Jun Lai, E. Turner Overton, Kevin McCormick, James A. Hoxie, Randall Tressler, Scott Sherrill-Mix, Janet M. Siliciano, Jonathan Z. Li, D. Brenda Salantes, Richard A. Koup, Tuhina Srivastava, Yu Zheng, Felicity Mampe, Gerald H. Learn, Frederic D. Bushman, Subul A. Beg, Katharine J. Bar
Publikováno v:
Journal of Clinical Investigation. 128:3102-3115
BACKGROUND. The effect of a brief analytical treatment interruption (ATI) on the HIV-1 latent reservoir of individuals who initiate antiretroviral therapy (ART) during chronic infection is unknown. METHODS. We evaluated the impact of transient viremi
Autor:
Lucio Gama, Richard A. Koup
Publikováno v:
Annual Review of Medicine. 69:409-419
Broadly neutralizing antibodies (bNAbs) have been evaluated as promising agents in the fight against infectious diseases. HIV-1-specific bNAbs, in particular, have been tested in both preventive and therapeutic modalities. Multiple bNAbs have been is
Autor:
Zachary Mankoff, Ronnie Wei, Dennis R. Burton, Krisha McKee, Dana M. Lord, Richard A. Koup, Christian Lange, Wulf Dirk Leuschner, Keyun Wang, Mario Roederer, Stephen D. Schmidt, Tongqing Zhou, Dan H. Barouch, Rebecca Sendak, Lawrence J. Tartaglia, Sijy O'Dell, Zhi Yong Yang, Misook Choe, Robert T. Bailer, Lan Wu, John R. Mascola, Mangaiarkarasi Asokan, Young Do Kwon, Amarendra Pegu, Ercole Rao, Ling Xu, Mark Connors, Peter D. Kwong, Jochen Kruip, Xuejun Chen, John-Paul Todd, Gejing Deng, Mark K. Louder, Gary J. Nabel, Nicole A. Doria-Rose, Christian Beil, Jochen Beninga
Publikováno v:
Science. 358:85-90
A triple threat for HIV The HIV virus continually evolves tricks to evade elimination by the host. Prevention and a cure will likely rely on broadly neutralizing antibodies that can recognize and conquer multiple viral strains or subtypes. Xu et al.
Autor:
Julie E, Ledgerwood, Adam D, DeZure, Daphne A, Stanley, Emily E, Coates, Laura, Novik, Mary E, Enama, Nina M, Berkowitz, Zonghui, Hu, Gyan, Joshi, Aurélie, Ploquin, Sandra, Sitar, Ingelise J, Gordon, Sarah A, Plummer, LaSonji A, Holman, Cynthia S, Hendel, Galina, Yamshchikov, Francois, Roman, Alfredo, Nicosia, Stefano, Colloca, Riccardo, Cortese, Robert T, Bailer, Richard M, Schwartz, Mario, Roederer, John R, Mascola, Richard A, Koup, Nancy J, Sullivan, Barney S, Graham, Sarah, Romano
Publikováno v:
New England Journal of Medicine. 376:928-938
BackgroundThe unprecedented 2014 epidemic of Ebola virus disease (EVD) prompted an international response to accelerate the availability of a preventive vaccine. A replication-defective recombinant chimpanzee adenovirus type 3–vectored ebolavirus v
Autor:
Florian Krammer, Sarah F. Andrews, Kenta Matsuda, Peter D. Kwong, Stephen A. Migueles, Adam K. Wheatley, Sarah Stuccio, Sam Darko, Marc Gurwith, Mark Connors, Jinghe Huang, Baoshan Zhang, Robert T. Bailer, Trevor Griesman, M. Gordon Joyce, Zizhang Sheng, Jeff Alexander, Alyssa A. Pullano, Elise Ishida, Jason Plyler, Yaroslav Tsybovsky, Byong H. Kang, Teddy John Wohlbold, Hana Golding, Tongqing Zhou, Kwanyee Leung, Richard A. Koup, Jon Smith, Adrian B. McDermott, Surender Khurana, Lyuba Bolkhovitinov, Crystal S.F. Cheung, Cinque Soto, Yongping Yang, Yicheng Guo, Lawrence Shapiro, Veronika Chromikova, C. Jason Liang, Sandeep Narpala, April Poole, Alberto Cagigi
Publikováno v:
Science Immunology. 4
Induction of an antibody response capable of recognizing highly diverse strains is a major obstacle to the development of vaccines for viruses such as HIV and influenza. Here, we report the dynamics of B cell expansion and evolution at the single-cel
Autor:
Samuel Darko, Brandon F. Keele, Nicolas W. Hengartner, Farida Laboune, Amy R. Henry, Katharine Best, Taina T. Immonen, Richard A. Koup, Frank Maldarelli, C. Jason Liang, Daniel C. Douek, David R. Ambrozak, Takuya Yamamoto, Alan S. Perelson, Jason M. Hataye, Joseph P. Casazza
Publikováno v:
Cell hostmicrobe. 26(6)
Summary A population at low census might go extinct or instead transition into exponential growth to become firmly established. Whether this pivotal event occurs for a within-host pathogen can be the difference between health and illness. Here, we de
Autor:
Jeffrey D. Lifson, John R. Mascola, Sean P. O’Brien, Theodora Hatziioannou, Paul D. Bieniasz, Jason Gorman, Brandon F. Keele, George M. Shaw, Gregory Q. Del Prete, Richard A. Koup, Taina T. Immonen, Adrienne E. Swanstrom, Christine M. Fennessey, Amarendra Pegu, Kathryn E. Foulds, Nicole A. Doria-Rose, Peter D. Kwong, Sung-Youl Ko, Mario Roederer, Carolyn Williamson, Stephen D. Schmidt, Hui Li
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 15, Iss 4, p e1007632 (2019)
PLoS Pathogens, Vol 15, Iss 4, p e1007632 (2019)
Chimeric Simian-Human Immunodeficiency Viruses (SHIVs) are an important tool for evaluating anti-HIV Env interventions in nonhuman primate (NHP) models. However, most unadapted SHIVs do not replicate well in vivo limiting their utility. Furthermore,