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Autor:
Ekram Nemr Abd Al Haleem, Sawsan Abo Bakr Zaytoon, Fatma Al –Zahraa Mohamed Ibrahim, Hossam M.M. Arafa
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 99:864-874
Peptic ulcers are one of the world's major gastrointestinal disorders, embracing both gastric and duodenal ulcers, and affecting 10% of the world population. The current study aimed to investigate the possible protective effect of tadalafil and pento
Autor:
William C. Wimley, Camille R. T. Bourgeois, Jing He, Venkateswara R Gogulamudi, Minolfa C. Prieto, Danielle Y Arita, Ryosuke Satou, Justine Jorgensen, Alexis A. Gonzalez
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Scientific Reports
Scientific Reports
Growing evidence indicates that prorenin receptor (PRR) is upregulated in collecting duct (CD) of diabetic kidney. Prorenin is secreted by the principal CD cells, and is the natural ligand of the PRR. PRR activation stimulates fibrotic factors, inclu
Autor:
Naoya Kakutani, Soichiro Hata, Satoshi Maekawa, Shingo Takada, Hideo Nambu, Yoshikuni Obata, Shintaro Kinugawa, Hikaru Hagiwara, Yoshizuki Fumoto, Takaaki Furihata, Arata Fukushima, Takashi Yokota, Ippei Nakano, Katsuma Yamanashi
Publikováno v:
Experimental Physiology. 106:1785-1793
NEW FINDINGS What is the central question of this study? We questioned whether an angiotensin-converting enzyme (ACE) inhibitor prevents skeletal muscle fibrosis in diabetic mice. What is the main finding and its importance? Administration of ACE inh
Autor:
Zhihao Liu, Guannan Meng, Xiaoxing Jin, Liping Zhou, Xiaoya Zhou, Lilei Yu, Hu Chen, Hong Jiang, Fuding Guo, Yanqiu Lai
Publikováno v:
Cardiovascular Research. 118:1821-1834
Aims The clinical use of antitumor agent doxorubicin (DOX) is hampered by its dose-dependent cardiotoxicity. Development of highly efficient and safe adjuvant intervention for preventing DOX-induced adverse cardiac events is urgently needed. We aimed
Autor:
Bruno Durante da Silva, Humberto Dellê, Gizele Alves Neves, Robson Luiz Bandoni, Fernanda Marciano Consolim-Colombo, Maria Helena Mattos Porter, Tercio Lemos de Moraes, Valentin A. Pavlov, Kátia De Angelis, Luis Ulloa, Pamela Nithzi Bricher Choque, Maria Claudia Irigoyen
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports
Scientific Reports
The mechanisms regulating immune cells recruitment into the heart during healing after an acute myocardial infarction (AMI) have major clinical implications. We investigated whether cholinergic stimulation with pyridostigmine, a cholinesterase inhibi
Autor:
Fernande Petingmve Peyembouo, Elvine Pami Nguelefack-Mbuyo, Christian Kuete Fofie, Télesphore Benoît Nguelefack
Publikováno v:
Journal of Basic and Clinical Physiology and Pharmacology. 33:457-469
Objectives Dexamethasone is used experimentally to induce insulin resistance and type 2 diabetes. However, data concerning the dose, the duration of treatment, and the associated comorbidities are inconsistent. The aim of this study was to compare th
Autor:
Anna Vavřínová, Ivana Vaněčková, Jaroslav Kuneš, Josef Zicha, Zdenka Dobešová, Hana Rauchová, Michal Behuliak
Publikováno v:
Hypertension Research. 44:1067-1078
Salt hypertensive Dahl rats are characterized by sympathoexcitation and relative NO deficiency. We tested the hypothesis that the increased blood pressure (BP) response to fasudil in salt hypertensive Dahl rats is due to augmented calcium sensitizati
Autor:
Martin Diener, Jasmin Ballout
Publikováno v:
Pflugers Archiv
Propionate, a metabolite from the microbial fermentation of carbohydrates, evokes a release of epithelial acetylcholine in rat caecum resulting in an increase of short-circuit current (Isc) in Ussing chamber experiments. The present experiments were
Autor:
Keliang Xie, Yi Chen, Yize Li, Linlin Zhang, Yuan Yuan, Chunyan Wang, Guolin Wang, Jing Li, Yonghao Yu
Publikováno v:
Neurosci Bull
Remifentanil is widely used to control intraoperative pain. However, its analgesic effect is limited by the generation of postoperative hyperalgesia. In this study, we investigated whether the impairment of transmembrane protein 16C (TMEM16C)/Slack i
Autor:
Ahmed Omar Touhami Ahami, Affaf Hafid, Ismail Louragli, Soukaina Chakib, Samir Bikri, Youssef Aboussaleh, Assia Berrani
Publikováno v:
Journal of Basic and Clinical Physiology and Pharmacology. 32:1031-1040
Objectives Several epidemiological data indicate that chronic hyperglycemia is associated with behavioral changes such as anxiety and depressive symptoms. Date seeds, one of the most potent products with potential antioxidant activities and possess m