Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Wenyu Lin"'
Autor:
Nadia Alatrakchi, Tuo Shao, Myung-Ho Kim, Wenyu Lin, Shadi Salloum, Raymond T. Chung, Annie J. Kruger, Andre J Jeyarajan, Kathleen E. Corey, Stuti Shroff, Andrew Kassa, Zhu Zhuo, Sanjoy K. Khan, Mozhdeh Sojoodi, Jacinta A Holmes, Esperance A. Schaefer
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 4, Pp 1297-1310 (2021)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims Patients with simple steatosis (SS) and nonalcoholic steatohepatitis can develop progressive liver fibrosis, which is associated with liver-related mortality. The mechanisms contributing to liver fibrosis development in SS, however,
Autor:
Chen Qu, Hao Wang, Shuang Peng, Xue Ning, Jian Hong, Aimin Li, Wenyu Lin, Yue Luo, Peng Chen, Xiaojun Luo, Penghui Xie, Guanqi Dai, Yuchuan Jiang
Publikováno v:
Experimental & Molecular Medicine
Experimental and Molecular Medicine, Vol 52, Iss 7, Pp 1062-1074 (2020)
Experimental and Molecular Medicine, Vol 52, Iss 7, Pp 1062-1074 (2020)
Dexmedetomidine (DEX) is an anesthetic that is widely used in the clinic, and it has been reported to exhibit paradoxical effects in the progression of multiple solid tumors. In this study, we sought to explore the mechanism by which DEX regulates he
Autor:
Tuo Shao, Qingzhen Yu, Jian Rong, Wenyu Lin, Xiaohong Wang, Viksit Kumar, Zhen Chen, Steven H. Liang, Vasily Belov, Anthony E. Samir, Xiaoyun Deng, Lixin Lang, Raymond T. Chung, Hualong Fu, Xiaoyuan Chen, Lee Josephson, Steve Rwema
Publikováno v:
Journal of Hepatology. 73:161-169
Background & Aims The vitronectin receptor integrin αvβ3 drives fibrogenic activation of hepatic stellate cells (HSCs). Molecular imaging targeting the integrin αvβ3 could provide a non-invasive method for evaluating the expression and the functi
Autor:
Jian Hong, Hengxing Chen, Wenyu Lin, Dandan Zheng, Mengxian Tu, Kaishun Hu, Peng Chen, Lehang Lin, Jun Fan, Guohua Cheng, Zelong Lin, Yuchuan Jiang, Jinying Li, Lu He, Hui Yuan, Chen Qu
Publikováno v:
Am J Pathol
Liver fibrosis is an increasing health problem worldwide, for which no effective antifibrosis drugs are available. Although the involvement of aerobic glycolysis in hepatic stellate cell (HSC) activation has been reported, the role of pyruvate kinase
Autor:
Winona Wu, Esperance A. Schaefer, Erik DiGiacomo, Shadi Salloum, Kathleen E. Corey, Charles Carlton-Smith, Raymond T. Chung, Andrew Yang, Cynthia Brisac, Christina Mark, Wenyu Lin
Publikováno v:
Hepatology Communications
The biological factors that promote inflammation or nonalcoholic steatohepatitis (NASH) in the setting of nonalcoholic fatty liver disease remain incompletely understood. Clinical studies have demonstrated an association between obstructive sleep apn
Autor:
Jay Luther, Martin L. Yarmush, Nadia Alatrakchi, Shadi Salloum, Raymond T. Chung, Annie J. Kruger, Anna Lidofsky, Rohit Jindal, Shyam Sundhar Bale, Cynthia Brisac, Dahlene N. Fusco, Wenyu Lin, Esperance A. Schaefer, Jacinta A. Holmes
Publikováno v:
Hepatology. 64:1951-1968
HIV/HCV co-infection accelerates progressive liver fibrosis, however the mechanisms remain poorly understood. HCV and HIV independently induce profibrogenic markers TGFβ1 (mediated by reactive oxygen species (ROS)) and NFκB in hepatocytes and hepat
Autor:
Jacinta A. Holmes, Yuchuan Jiang, Wenyu Lin, Dandan Zheng, Mengxian Tu, Yadi Liao, Weiming Li, Hui Yuan, Bryan C. Fuchs, Xijun Chen, Jian Hong, Lu He, Qimeng Jin, Yingjun Liu, Sai Li, Qiaoting Hu, Zelong Lin, Raymond T. Chung, Lan Wei, Jianning Chen, Anna Lidofsky, Chen Qu
Publikováno v:
Hepatology (Baltimore, Md.). 68(3)
Spleen tyrosine kinase (SYK) plays a critical role in immune cell signaling pathways and has been reported as a biomarker for human hepatocellular carcinoma (HCC). We sought to investigate the mechanism by which SYK promotes liver fibrosis and to eva
Autor:
Hong Zhao, Leiliang Zhang, Guoyang Wu, Shaoyong Li, Kattareeya Kumthip, Ethan M. Weinberg, Wen-Chi Chen, Mark A. Brockman, Wenyu Lin, Nikolaus Jilg, Lee F. Peng, Jorge Méndez-Navarro, Detlef Schuppan, Kaku Goto, Raymond T. Chung
Publikováno v:
The Journal of Biological Chemistry
HIV/HCV coinfection leads to accelerated hepatic fibrosis progression, with higher rates of cirrhosis, liver failure, and liver death than does HCV mono-infection. However, the profibrogenic role of HIV on hepatocytes and hepatic stellate cells (HSC)