Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Irene M. Ghobrial"'
Autor:
Jorge J. Castillo, Kirsten Meid, Maria Luisa Guerrera, Guang Yang, Irene M. Ghobrial, Steven P. Treon, Jacob D. Soumerai, Alan P Skarbnik
Publikováno v:
Blood. 135:1912-1915
Treon et al provide early clinical data supporting a theoretical rationale for continuing ibrutinib in patients receiving the drug during COVID-19 illness.
Autor:
Jordan Rossen, Alexandre Detappe, Mairead Reidy, John L. Markley, Mustafa Kocak, Prathapan Thiru, Kai Cai, Nora Kory, Irene M. Ghobrial, Guillaume Kugener, Weiwen Ying, Peter Tsvetkov, Luke Whitesell, Aviad Tsherniak, Zarina Brune, Susan Lindquist, Todd R. Golub, Sandro Santagata, Heather R. Keys
Publikováno v:
Nature chemical biology
The mechanisms by which cells adapt to proteotoxic stress are largely unknown, but are key to understanding how tumor cells, particularly in vivo, are largely resistant to proteasome inhibitors. Analysis of cancer cell lines, mouse xenografts and pat
Autor:
Philippe Armand, Damian R. Handisides, Irene M. Ghobrial, Jacalyn Rosenblatt, Kenneth C. Anderson, Jacquelyn Hedlund, Paul G. Richardson, Henry Dumke, Bradley Rivotto, Stacey Chuma, Robert L. Schlossman, Kenneth H. Shain, Stew Kroll, Patrick Henrick, Chia Jen Liu, Noopur Raje, Michael Gary Martin, Alexandra Savell, Andrew Yee, Craig Reynolds, Kalvis Hornburg, Laura Stampleman, Jacob P. Laubach, Ira Zackon
Publikováno v:
Clinical Cancer Research. 25:478-486
Purpose: The presence of hypoxia in the diseased bone marrow presents a new therapeutic target for multiple myeloma. Evofosfamide (formerly TH-302) is a 2-nitroimidazole prodrug of the DNA alkylator, bromo-isophosphoramide mustard, which is selective
Autor:
Alexandre Detappe, Aviad Tsherniak, Irene M. Ghobrial, Peter Tsvetkov, Kai Cai, Prathapan Thiru, Sandro Santagata, Heather R. Keys, Zarina Brune, Susan Lindquist, Mairead Reidy, Guillaume Kugener, Luke Whitesell, John L. Markley, Weiwen Ying
SUMMARYThe mechanisms used by cancer cells to resist the severe disruption in protein homeostasis caused by proteasome inhibitors remain obscure. Here, we show this resistance correlates with a metabolic shift from glycolysis to oxidative phosphoryla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc3b7176efc5970ff474b06de9bf7f40
Publikováno v:
Leukemia & Lymphoma. 57:2699-2701
Lymphoplasmacytic lymphoma (LPL) is characterized by involvement of the bone marrow and other sites by a monoclonal population of B-cells, lymphoplasmacytoid and plasma cells. In over 95% of LPL ca...
Autor:
Paul A. Baldock, Graham R. Williams, Babatunde O. Oyajobi, Alyson Morse, Anja Seckinger, Irene M. Ghobrial, Heather Fairfield, Lawrence M. T. Le, Tri Giang Phan, Peter I. Croucher, David G. Little, Tegan L. Cheng, Scott E. Youlten, David Abi-Hanna, Rachael L. Terry, Michaela Kneissel, Dirk Hose, Jessica A. Pettitt, Ina Kramer, Karin Vanderkerken, Michaela R. Reagan, Sindhu T. Mohanty, Carolyne Falank, Michelle M. McDonald, Marija K. Simic, J. H. Duncan Bassett
Multiple myeloma (MM) is a plasma cell cancer that develops in the skeleton causing profound bone destruction and fractures. The bone disease is mediated by increased osteoclastic bone resorption and suppressed bone formation. Bisphosphonates used fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de64ffc5e9c51813da549154b2c6cc9b
https://hdl.handle.net/20.500.14017/7adae6a1-cb61-4b8a-8c47-16347906c559
https://hdl.handle.net/20.500.14017/7adae6a1-cb61-4b8a-8c47-16347906c559
Autor:
Tegan L. Cheng, Ina Kramer, Irene M. Ghobrial, Peter I. Croucher, Sindhu T. Mohanty, Cliff J. Rosen, Mary L. Bouxsein, Michelle M. McDonald, Michaela Kneissel, Rachael L. Terry, Michaela R. Reagan, David G. Little, Lawrence Le, Daniel J. Brooks, Jessica A. Pettitt
Publikováno v:
Bone Abstracts.
Publikováno v:
Annals of Oncology
We review the available trial data for novel regimens, recently updated treatment guidelines, and the practical considerations for treatment selection in patients with Waldenström's macroglobulinemia (WM). This comprehensive review will help inform
Autor:
Aldo M. Roccaro, Yuji Mishima, Michaela R. Reagan, Yong Zhang, Bo Jiang, Siobhan Glavey, Xavier Leleu, Irene M. Ghobrial, Yu Zhang, Yaoyu E. Wang, Wenjing Zhang, Salomon Manier, Antonio Sacco
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 10, p e110973 (2014)
PLoS ONE, Vol 9, Iss 10, p e110973 (2014)
Epigenetic changes frequently occur during tumorigenesis and DNA hypermethylation may account for the inactivation of tumor suppressor genes in cancer cells. Studies in Multiple Myeloma (MM) have shown variable DNA methylation patterns with focal hyp
Autor:
Kenneth C. Anderson, Bradley Rivotto, Paul G. Richardson, Patrick Henrick, Alexandra Savell, Irene M. Ghobrial, Ashraf Badros, Rodrigo O. Maegawa, Jacalyn Rosenblatt, Saad Z. Usmani, Andrew Yee, James J. Vredenburgh, Claudia E. Paba-Prada, Jeffrey Matous, Charles M. Farber, Joseph Cappuccio, Kaitlen Reyes, Aaron M. Caola, Jeffrey S. Wisch, Robert L. Schlossman, Jacob P. Laubach, Kimberly Noonan, Nikhil C. Munshi
Publikováno v:
Blood. 128:976-976
Background This study aimed to determine the benefit of early therapeutic intervention with the combination of elotuzumab, Lenalidomide, and Dexamethasone in patients with high-risk smoldering multiple myeloma (SMM). ClinicalTrials.gov Identifier: NC