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Publikováno v:
Critical reviews in biochemistry and molecular biology. 56(4):426-439
Plasma levels of high-density lipoprotein (HDL) inversely correlate with the incidence of cardiovascular diseases (CVD). The causal relationship between plasma HDL-cholesterol levels and CVD has been called into question by Mendelian randomization st
Autor:
In Jeoung Baek, Dae Won Jun, Brian Raught, Eun-Jung Jin, Chang Yeob Han, Jinsoo Song, Peter K. Kim, Sujeong Park, Kyu Yun Jang
Publikováno v:
Experimental & Molecular Medicine
In this study, we hypothesized that deregulation in the maintenance of the pool of coenzyme A (CoA) may play a crucial role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Specific deletion of Acot12 (Acot12−/−), the major acyl-C
Publikováno v:
Open Access Macedonian Journal of Medical Sciences. 9:352-355
BACKGROUND: Basically, body regulates various harmful substances, including nicotine and tar which were carried by cigarette smoke. Nicotine which accumulated in blood was transported to liver to be metabolized and excreted in kidneys. The metabolism
Autor:
Tarique Mahmood, Abdullah Ansari, Farogh Ahsan, Paramdeep Bagga, Mohammad Shariq, Ranjan Kumar, Arshiya Shamim, Shoaib Ahmad
Publikováno v:
Journal of Complementary and Integrative Medicine. 19:27-36
Objectives Comparative evaluation of cardioprotective activity of Gala and Fuji apple juice against isoprenaline induced cardiotoxicity in rats. Methods Rats (125–150 g) were orally administered Gala (GA) and Fuji (FA) apple juice (3 mL/day, per or
Autor:
Klaus G. Parhofer, Anja Kerksiek, Bediha Bölükbasi, Ulrich Laufs, Dieter Lütjohann, Frans Stellaard
Publikováno v:
British Journal of Clinical Pharmacology. 87:4252-4261
AIMS The serum ratios of the brain-specific oxysterol 24S-hydroxycholesterol (24S-OHC) to cholesterol and to 27-OHC reflect brain cholesterol turnover. We studied the effect of proprotein convertase subtilisin/kexin type 9 monoclonal antibodies (PCSK
Publikováno v:
Clínica e Investigación en Arteriosclerosis. 33:50-55
Dysbetalipoproteinaemia (or type III hyperlipoproteinaemia) is a severe mixed hyperlipidaemia resulting from the accumulation of remnant chylomicron and VLDL particles in plasma, also called β-VLDL. It is caused by a defect in the recognition by hep
Autor:
Tong-Cun Zhang, Chang Wang, Qing-Qing Dong, Rui Huang, Zhongyuan Li, Nan Wang, Wei Zhao, Yajian Song, Hai-Jie Hu, Xue-Gang Luo
Publikováno v:
Bioscience, Biotechnology, and Biochemistry. 85:1395-1404
Liraglutide is an analogue of human glucagon-like peptide-1 (GLP-1), an endogenous intestinal hormone which play essential roles in the regulation of glycolipid metabolism. To investigate the role of lactic acid bacteria (LAB) in the lipid-lowering e
Autor:
Ahmed Omar Touhami Ahami, Affaf Hafid, Ismail Louragli, Soukaina Chakib, Samir Bikri, Youssef Aboussaleh, Assia Berrani
Publikováno v:
Journal of Basic and Clinical Physiology and Pharmacology. 32:1031-1040
Objectives Several epidemiological data indicate that chronic hyperglycemia is associated with behavioral changes such as anxiety and depressive symptoms. Date seeds, one of the most potent products with potential antioxidant activities and possess m
Publikováno v:
Endocrine, Metabolic & Immune Disorders - Drug Targets. 21:352-359
Background: Endothelial nitric oxide synthase (eNOS) plays a major role in the response of anti-hypercholesterol statin drugs. Genetic polymorphisms in the eNOS gene affect the activity of eNOS thereby modulating the statin response. Objectives: This
Autor:
Thiago C. Genaro-Mattos, Allison Anderson, Zeljka Korade, Luke B. Allen, Keri A. Tallman, Ned A. Porter, Karoly Mirnics
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-9 (2021)
Translational Psychiatry
Translational Psychiatry
Trazodone (TRZ) is a commonly prescribed antidepressant with significant off-label use for insomnia. A recent drug screening revealed that TRZ interferes with sterol biosynthesis, causing elevated levels of sterol precursor 7-dehydrocholesterol (7-DH