Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Kevin J Harrington"'
Autor:
Keith C. Bible, Irene Brana, Mollie Leoni, Stephan Hackenberg, Jessica Bauman, Pol Specenier, Jérôme Fayette, Catherine Rose Scholz, Binaifer Balsara, Maria Jose Flor, Bridget Martell, Alan L. Ho, Robert I. Haddad, Valentina Boni, Caroline Even, Sjoukje F. Oosting, Sung-Bae Kim, Kevin J. Harrington, Nabil F. Saba, Francis P. Worden, Antonio Gualberto, Lisa Licitra, Ioanna Nixon, Deborah J. Wong, Myung-Ju Ahn
Publikováno v:
Journal of clinical oncology
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 39(17):JCO2002903, 1856-1864. AMER SOC CLINICAL ONCOLOGY
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 39(17):JCO2002903, 1856-1864. AMER SOC CLINICAL ONCOLOGY
PURPOSEMutations in the HRAS (m HRAS) proto-oncogene occur in 4%-8% of patients with recurrent and/or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC). Tipifarnib is a farnesyltransferase inhibitor that disrupts HRAS function. We evalua
Autor:
Timothy Kottke, Laura Evgin, Christopher B. Driscoll, Phonphimon Wongthida, Jill Thompson, Brady Zell, Adel Samson, Jason M. Tonne, Amanda L. Huff, Lewis R. Roberts, Elizabeth Ilett, Peter Selby, Alan Melcher, Kevin J. Harrington, Jacob van Vloten, Mitesh J. Borad, Hardev Pandha, Matthew Schuelke, Richard G. Vile, Mark A. McNiven, Victoria A. Jennings, Jose S. Pulido
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
In our clinical trials of oncolytic vesicular stomatitis virus expressing interferon beta (VSV-IFNβ), several patients achieved initial responses followed by aggressive relapse. We show here that VSV-IFNβ-escape tumors predictably express a point-m
Autor:
M. Denyer, Nicola E. Annels, Guy Simpson, Kevin J. Harrington, Richard G. Vile, Mehreen Arif, Hardev Pandha, Alan Melcher, Matthew C. Coffey
Publikováno v:
Molecular Therapy Oncolytics
Molecular Therapy: Oncolytics, Vol 20, Iss, Pp 434-446 (2021)
Molecular Therapy: Oncolytics, Vol 20, Iss, Pp 434-446 (2021)
Prostate cancers are considered “cold” tumors characterized by minimal T cell infiltrates, absence of a type I interferon (IFN) signature, and the presence of immunosuppressive cells. This non-inflamed phenotype is likely responsible for the lack
Publikováno v:
Clinical Cancer Research. 27:689-703
Therapeutic cancer vaccines, an exciting development in cancer immunotherapy, share the goal of creating and amplifying tumor-specific T-cell responses, but significant obstacles still remain to their success. Here, we briefly outline the principles
Autor:
Burak Gumuscu, Kevin J. Harrington, Hoi-Shen Radcliffe, Lillian L. Siu, Wendy Snyder, Danny Rischin, Beatriz Castelo Fernandez, Ezra E.W. Cohen, Jason Chesney, Anthony Kong, Jonathan D. Cheng, Nicolas Mach
Publikováno v:
Clinical Cancer Research, Vol. 26, No 19 (2020) pp. 5153-5161
Purpose: The prognosis for patients with recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) is poor, and only a minority of patients benefit from checkpoint immunotherapy. Talimogene laherparepvec (T-VEC), an oncolytic immunoth
Autor:
F. Stephen Hodi, Kevin J. Harrington, Archie N. Tse, David C. Madoff, Jason J. Luke, Andrea Marie Perrone, Lawrence H. Schwartz, Anuradha D. Khilnani, Robert H.I. Andtbacka, Aurélien Marabelle, Gregory V. Goldmacher
Publikováno v:
Journal of Clinical Oncology
3141 Background: The approval of intratumoral (IT) immunotherapy for metastatic melanoma and the active development of numerous novel IT drugs have created a need for standardized evaluation of response to this unique treatment strategy. The Response
Autor:
Johannes A. Langendijk, Jordi Giralt, Matthias Guckenberger, Jørgen Johansen, John Waldron, Shlomo A. Koyfman, Danielle N. Margalit, Jimmy J. Caudell, Panagiotis Balermpas, Ying J. Hitchcock, Johannes H.A.M. Kaanders, Sandro V. Porceddu, Jonathan J. Beitler, Pierre Blanchard, Yoke Lim Soong, Michelle Mierzwa, June Corry, David M. Brizel, Wilfred Budach, David A. Palma, Sue S. Yom, Adam S. Garden, Vincent Grégoire, Nancy Y. Lee, Mererid Evans, Renzo Corvò, Ying Sun, Quynh-Thu Le, Kevin J. Harrington, Paul M. Harari, Juliette Thariat, David J Thomson
Publikováno v:
Radiotherapy and Oncology, 151, pp. 314-321
International Journal of Radiation Oncology, Biology, Physics, 107, 618-627
Scientia
Radiotherapy and Oncology, 151, 314-321. ELSEVIER IRELAND LTD
Thomson, D J, Palma, D, Guckenberger, M, Balermpas, P, Beitler, J J, Blanchard, P, Brizel, D, Budach, W, Caudell, J, Corry, J, Corvo, R, Evans, M, Garden, A S, Giralt, J, Gregoire, V, Harari, P M, Harrington, K, Hitchcock, Y J, Johansen, J, Kaanders, J, Koyfman, S, Langendijk, J A, Le, Q T, Lee, N, Margalit, D, Mierzwa, M, Porceddu, S, Soong, Y L, Sun, Y, Thariat, J, Waldron, J & Yom, S S 2020, ' Practice Recommendations for Risk-Adapted Head and Neck Cancer Radiation Therapy During the COVID-19 Pandemic : An ASTRO-ESTRO Consensus Statement ', International Journal of Radiation Oncology Biology Physics, vol. 107, no. 4, pp. 618-627 . https://doi.org/10.1016/j.ijrobp.2020.04.016
International journal of radiation oncology, biology, physics, vol 107, iss 4
International Journal of Radiation Oncology, Biology, Physics
Thomson, D J, Palma, D, Guckenberger, M, Balermpas, P, Beitler, J J, Blanchard, P, Brizel, D, Budach, W, Caudell, J, Corry, J, Corvo, R, Evans, M, Garden, A S, Giralt, J, Gregoire, V, Harari, P M, Harrington, K, Hitchcock, Y J, Johansen, J, Kaanders, J, Koyfman, S, Langendijk, J A, Le, Q T, Lee, N, Margalit, D, Mierzwa, M, Porceddu, S, Soong, Y L, Sun, Y, Thariat, J, Waldron, J & Yom, S S 2020, ' Practice recommendations for risk-adapted head and neck cancer radiotherapy during the COVID-19 pandemic : An ASTRO-ESTRO consensus statement ', Radiotherapy and Oncology, vol. 151, pp. 314-321 . https://doi.org/10.1016/j.radonc.2020.04.019
Radiotherapy and Oncology, 151, 314-321
Radiotherapy and Oncology
International Journal of Radiation Oncology, Biology, Physics, 107, 4, pp. 618-627
International Journal of Radiation Oncology, Biology, Physics, 107(4), 618-627. ELSEVIER SCIENCE INC
International Journal of Radiation Oncology, Biology, Physics, 107, 618-627
Scientia
Radiotherapy and Oncology, 151, 314-321. ELSEVIER IRELAND LTD
Thomson, D J, Palma, D, Guckenberger, M, Balermpas, P, Beitler, J J, Blanchard, P, Brizel, D, Budach, W, Caudell, J, Corry, J, Corvo, R, Evans, M, Garden, A S, Giralt, J, Gregoire, V, Harari, P M, Harrington, K, Hitchcock, Y J, Johansen, J, Kaanders, J, Koyfman, S, Langendijk, J A, Le, Q T, Lee, N, Margalit, D, Mierzwa, M, Porceddu, S, Soong, Y L, Sun, Y, Thariat, J, Waldron, J & Yom, S S 2020, ' Practice Recommendations for Risk-Adapted Head and Neck Cancer Radiation Therapy During the COVID-19 Pandemic : An ASTRO-ESTRO Consensus Statement ', International Journal of Radiation Oncology Biology Physics, vol. 107, no. 4, pp. 618-627 . https://doi.org/10.1016/j.ijrobp.2020.04.016
International journal of radiation oncology, biology, physics, vol 107, iss 4
International Journal of Radiation Oncology, Biology, Physics
Thomson, D J, Palma, D, Guckenberger, M, Balermpas, P, Beitler, J J, Blanchard, P, Brizel, D, Budach, W, Caudell, J, Corry, J, Corvo, R, Evans, M, Garden, A S, Giralt, J, Gregoire, V, Harari, P M, Harrington, K, Hitchcock, Y J, Johansen, J, Kaanders, J, Koyfman, S, Langendijk, J A, Le, Q T, Lee, N, Margalit, D, Mierzwa, M, Porceddu, S, Soong, Y L, Sun, Y, Thariat, J, Waldron, J & Yom, S S 2020, ' Practice recommendations for risk-adapted head and neck cancer radiotherapy during the COVID-19 pandemic : An ASTRO-ESTRO consensus statement ', Radiotherapy and Oncology, vol. 151, pp. 314-321 . https://doi.org/10.1016/j.radonc.2020.04.019
Radiotherapy and Oncology, 151, 314-321
Radiotherapy and Oncology
International Journal of Radiation Oncology, Biology, Physics, 107, 4, pp. 618-627
International Journal of Radiation Oncology, Biology, Physics, 107(4), 618-627. ELSEVIER SCIENCE INC
Càncer de cap i coll; Radioteràpia; Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV Cáncer de cabeza y cuello; Terapia de radiación; Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV Head and Neck Cancer; Radiation Therapy; Coronavirus SARS-CoV-2; COVID-19
Autor:
Magnus T. Dillon, Martin McLaughlin, Anna Wilkins, Kevin J. Harrington, Malin Pedersen, Alan Melcher, Emmanuel C Patin
Publikováno v:
Nature Reviews Cancer. 20:203-217
The development of immune checkpoint inhibitors (ICIs) is revolutionizing the way we think about cancer treatment. Even so, for most types of cancer, only a minority of patients currently benefit from ICI therapies. Intrinsic and acquired resistance
Autor:
Joan N. Kyula, Gabriella Baker, David Mansfield, Matthew Chiu, Anna Wilkins, Kevin J. Harrington, Eva Crespo-Rodriguez, Edward Armstrong, Alan Melcher, Martin McLaughlin, Fiona McDonald, Vicki Jennings, Victoria Roulstone, Shane Foo, Malin Pedersen, Galabina Bozhanova, Lorna Grove, Emmanuel C Patin
Publikováno v:
Expert Opinion on Biological Therapy. 20:635-652
Introduction: Immune checkpoint inhibitors (ICI) have dramatically improved the outcome for cancer patients across multiple tumor types. However the response rates to ICI monotherapy remain relativ...
Autor:
Bas W. Raaymakers, Marcel Verheij, Bruce D. Minsky, Jan J W Lagendijk, Arjun Sahgal, Parag J. Parikh, William A. Hall, Kevin J. Harrington, Ananya Choudhury, Robert J H A Tersteeg, Clifton D. Fuller, Uulke A. van der Heide, Eric S. Paulson, Michael F. Bassetti, Laura A. Dawson, Percy Lee, David A. Jaffray, Beth Erickson, Clifford G. Robinson, X. Allen Li, Christopher J. Schultz
Publikováno v:
Eur J Cancer
European Journal of Cancer, 122, pp. 42-52
European Journal of Cancer, 122, 42-52
European Journal of Cancer, 122, 42. Elsevier Limited
Hall, W A, Paulson, E S, Heide, U A V D, Fuller, C D, Raaymakers, B W, Lagendijk, J J W, Li, X A, Jaffray, D A, Dawson, L A, Erickson, B, Verheij, M, Harrington, K J, Sahgal, A, Lee, P, Parikh, P J, Bassetti, M F, Robinson, C G, Choudhury, A, Tersteeg, J H A & Schultz, C J 2019, ' The Transformation Of Radiation Oncology Using Real-Time Magnetic Resonance Guidance : A Review ', European Journal of Cancer . https://doi.org/10.1016/j.ejca.2019.07.021
European Journal of Cancer, 122, pp. 42-52
European Journal of Cancer, 122, 42-52
European Journal of Cancer, 122, 42. Elsevier Limited
Hall, W A, Paulson, E S, Heide, U A V D, Fuller, C D, Raaymakers, B W, Lagendijk, J J W, Li, X A, Jaffray, D A, Dawson, L A, Erickson, B, Verheij, M, Harrington, K J, Sahgal, A, Lee, P, Parikh, P J, Bassetti, M F, Robinson, C G, Choudhury, A, Tersteeg, J H A & Schultz, C J 2019, ' The Transformation Of Radiation Oncology Using Real-Time Magnetic Resonance Guidance : A Review ', European Journal of Cancer . https://doi.org/10.1016/j.ejca.2019.07.021
Radiation therapy (RT) is an essential component of effective cancer care and is used across nearly all cancer types. The delivery of RT is becoming more precise through rapid advances in both computing and imaging. The direct integration of magnetic