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Case report: Emergence of dolutegravir resistance in a patient on second-line antiretroviral therapy
Autor:
Graeme Meintjes, Liezl Dunn, Carole L. Wallis, Gary Maartens, Kairoonisha Mahomed, Shavani Maharaj
Publikováno v:
Southern African Journal of HIV Medicine; Vol. 21 No. 1 (2020)
Southern African Journal of HIV Medicine
Southern African Journal of HIV Medicine, Vol 21, Iss 1, Pp e1-e2 (2020)
Southern African Journal of HIV Medicine, Volume: 21, Issue: 1, Pages: 1-4, Published: 2020
Southern African Journal of HIV Medicine
Southern African Journal of HIV Medicine, Vol 21, Iss 1, Pp e1-e2 (2020)
Southern African Journal of HIV Medicine, Volume: 21, Issue: 1, Pages: 1-4, Published: 2020
Introduction: The integrase strand transfer inhibitor dolutegravir (DTG) has a high genetic barrier to resistance. Only rare cases of resistance to DTG have been reported when it is used as a component of antiretroviral therapy regimens in treatment-
Autor:
Michael J. Vjecha, Alimuddin Zumla, Giovanni Battista Migliori, Jessica Galvin, Adam Zumla, Simon Tiberi
Publikováno v:
International Journal of Infectious Diseases
International Journal of Infectious Diseases, Vol 113, Iss, Pp S96-S99 (2021)
International Journal of Infectious Diseases, Vol 113, Iss, Pp S96-S99 (2021)
The WHO 2020 global TB Report estimates that in 2019 there were an estimated 500,000 cases of multi-drug resistant TB (MDR-TB) of which only 186,772 MDR-TB cases were diagnosed, and positive treatment outcomes were achieved in 57% of them. These data
Autor:
Jin-Yuan Wang, Li-Min Huang, Fu-Yuan Huang, Hsin Chi, Ching-Ying Huang, Yi-Hsuan Tu, Chien-Wei Lee, Nan-Chang Chiu, Yu-Lin Tai, Daniel Tsung-Ning Huang
Publikováno v:
Journal of Microbiology, Immunology and Infection, Vol 54, Iss 5, Pp 876-884 (2021)
Purpose This study aimed to compare the safety and efficacy of clarithromycin-naproxen-oseltamivir combination therapy to that of oseltamivir therapy alone in hospitalized pediatric influenza patients. Methods This prospective, single-blind study inc
Autor:
Biljana Carevic, Jonathan Lellouche, Yehuda Carmeli, Shimrit Cohen-Percia, Joseph M. Klausner, Sammy Frenk, Amir Nutman, Stéphan Juergen Harbarth, Elizabeth Temkin, Tomer Hoffman, Yehuda Kariv, Noga Fallach
Publikováno v:
Clinical Microbiology and Infection. 27:1481-1487
Objectives Compared to cephalosporin-based prophylaxis, ertapenem prophylaxis lowers the risk of surgical site infection among carriers of extended-spectrum β-lactamase-producing Enterobacterales (ESBL-PEs) undergoing colorectal surgery. We aimed to
Autor:
Naoki Hosogaya, Hiroshi Mukae, Masakazu Fujiwara, Yoshitake Kitanishi, Keiichi Honda, Hideyuki Miyauchi, Taiga Miyazaki, Hideaki Watanabe, Shinpei Iwata, Takuji Komeda, Kanae Hara, Eriko Ogura, Takahiro Takazono, Yoshikazu Ajisawa
Publikováno v:
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Background Baloxavir marboxil (baloxavir) is a single-dose, oral antiinfluenza drug with a novel mechanism of action. We compared the incidence of hospitalization in patients treated with baloxavir vs neuraminidase inhibitors. Methods In this retrosp
Autor:
Cissy Kityo, Stephen D. Barr, Emmanuel Ndashimye, Abayomi S Olabode, Miguel E. Quiñones-Mateu, Yue Li, Paul S Reyes, Fred Kyeyune, Mariano Avino, Immaculate Nankya, Eric J. Arts
Publikováno v:
J Antimicrob Chemother
Objectives The second-generation integrase strand transfer inhibitor (INSTI) bictegravir is becoming accessible in low- and middle-income countries (LMICs), and another INSTI, cabotegravir, has recently been approved as a long-acting injectable. Data
Publikováno v:
Journal of Antimicrobial Chemotherapy
Objectives To evaluate the effects of concomitant efavirenz-based ART and genetic polymorphism on the variability in rifampicin and 25-desacetylrifampicin pharmacokinetics. Patients and methods Plasma concentrations of rifampicin and 25-desacetylrifa
Autor:
Xiaohong Pan, Lei Pan, Minjie Mao, Xiao-bo Ji, Xiao-qing Huang, Caihong Wang, Junke Qiu, Yang Zhou, Jiekun Xu
Publikováno v:
BMC Infectious Diseases, Vol 21, Iss 1, Pp 1-8 (2021)
BMC Infectious Diseases
BMC Infectious Diseases
Background Disseminated nocardiosis is liable to be misdiagnosed owing to the non-specific clinical manifestations and laboratory/imaging findings. Metagenomic next-generation sequencing (mNGS) is a culture-independent and rapid method for direct ide
Autor:
Qiwen Yang, Jingjia Zhang, Yingchun Xu, Ge Zhang, Simeng Duan, Yang Yang, Dongxue Li, Hui Zhang
Publikováno v:
Journal of Microbiology, Immunology and Infection, Vol 54, Iss 4, Pp 639-648 (2021)
Background We describe antibiotic resistance trends of Klebsiella pneumoniae pathogens, responsible for urinary tract infections (UTIs) and intra-abdominal infections (IAIs), isolated from different organs and tissues, hospital departments and Chines
Autor:
Orawan Anunsittichai, Panida Srisan, Thitima Wattanavijitkul, Siriporn Sangkhamal, Warumphon Sukkummee, Noppadol Wacharachaisurapol, Prawat Chantharit, Warunee Punpanich Vandepitte, Thanyawee Puthanakit
Publikováno v:
International Journal of Infectious Diseases, Vol 109, Iss, Pp 230-237 (2021)
Objectives The aim of this study was to describe the population pharmacokinetics of intravenous colistin use in children and to propose optimal dosage regimens. Methods A prospective, multicenter, population pharmacokinetic (PPK) study was conducted.