Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Gregory B Lesinski"'
Autor:
Matthew R. Farren, Yan Tong, Safi Shahda, Cameron Herting, Tanios Bekaii-Saab, Gregory B. Lesinski, Bert H. O'Neil, Bassel F. El-Rayes, Ziyue Liu, Christina Wu, Walid L. Shaib, Thomas A. Mace, Christopher McQuinn, Anne M. Noonan
Publikováno v:
Cancer Immunol Immunother
Modified FOLFOX6 is an established therapy for patients with metastatic colorectal cancer (mCRC). We conducted a single-arm phase Ib study to address the hypothesis that addition of pembrolizumab to this regimen could safely and effectively improve p
Autor:
Gregory B. Lesinski
Publikováno v:
Gut
OBJECTIVE: This study exploits the intersection between molecular-targeted therapies and immune-checkpoint inhibition to define new means to treat pancreatic cancer. DESIGN: Patient-derived cell lines and xenograft models were used to define the resp
Autor:
Stephen J. Pandol, Jo Ann Rinaudo, Darwin L. Conwell, Steven J. Hughes, Douglas S. Fishman, Mark E. Lowe, Hanno Steen, Robert Y. Liu, William E. Fisher, Amer Abouhamze, Amy L. McElhany, Ziding Feng, Zobeida Cruz-Monserrate, Gregory B. Lesinski, Sudhir Srivastava, Mark Topazian, David M. Troendle, Thomas A. Mace, Zachary M. Sellers, Ria Ghosh, Robert Orr, Dhiraj Yadav, Phil A. Hart, David C. Whitcomb, Jose Serrano, Aliye Uc, Emily Y. Lu, George Van Buren
Publikováno v:
Pancreas. 47(10)
High-quality and well-annotated biorepositories are needed to better understand the pathophysiology and biologic mechanisms of chronic pancreatitis (CP) and its consequences. We report a methodology for the development of a robust standard operating
Publikováno v:
Journal for Immunotherapy of Cancer
Pancreatic ductal adenocarcinoma (PDAC) is plagued by a dismal 5-year survival rate, early onset of metastasis and limited efficacy of systemic therapies. This scenario highlights the need to fervently pursue novel therapeutic strategies to treat thi
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 9 (2018)
Frontiers in Immunology, Vol 9 (2018)
Pancreatic cancer has a dismal prognosis and effective treatment options are limited. It is projected to be the second most common cause of cancer related mortality in the United States by 2030 and there is urgent unmet need for novel systemic treatm
Autor:
Hannah M. Komar, Avner Friedman, Gregory B. Lesinski, Phil A. Hart, Wenrui Hao, Darwin L. Conwell
Significance Chronic pancreatitis is a progressive inflammatory disease that inflicts hundreds of thousands of people annually in the United State alone, and it has no effective treatment. In the present paper we develop a mathematical model of the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74b6ff6d5c1fca916a327111eeaa3dce
https://europepmc.org/articles/PMC5441692/
https://europepmc.org/articles/PMC5441692/
Autor:
Susan N. Thomas, Brian Pollack, Gregory B. Lesinski, Yun Min Chang, Maiko Sasaki, Edmund K. Waller, Anna E. Kersh, Haydn T. Kissick, Spencer Ng, Ragini R. Kudchadkar
Publikováno v:
Journal of clinical pharmacology. 58(1)
Two pharmacologic approaches that are currently at the forefront of treating advanced cancer are those that center on disrupting critical growth/survival signaling pathways within tumor cells (commonly referred to as "targeted therapies") and those t
Autor:
Brian Olson, Michael C. Lowe, Maurice Zauderer, Desa Rae Pastore, Crystal Mallow, Conor E. Steuer, John E. Leonard, Ernest S. Smith, Elizabeth E. Evans, Gregory B. Lesinski, Nabil F. Saba, Christina Wu, Ragini R. Kudchadkar, Terrence L. Fisher
Publikováno v:
Cancer Research. 79:CT016-CT016
Interrogation of the tumor microenvironment (TME) is crucial to provide insight into biological activity, resistance mechanisms and implementation of rational combination immunotherapies. Semaphorin 4D (SEMA4D, CD100) has broad immunomodulatory effec
Autor:
Bassel F. El-Rayes, Cynthia Timmers, John L. Marshall, Tanios Bekaii-Saab, Shubham Pant, Santiago Aparo, Sanaa Tahiri, Sameh Mikhail, Susan Geyer, Miguel A. Villalona-Calero, Kristen K. Ciombor, Gregory B. Lesinski, Anne M. Noonan, Daniel H. Ahn, Thomas A. Mace, Christina Wu, James A. Zwiebel, Jennifer Sexton, Matthew R. Farren, Ying Huang
Pelareorep causes oncolysis in tumor cells with activated Ras. We hypothesized that pelareorep would have efficacy and immunomodulatory activity in metastatic pancreatic adenocarcinoma (MPA) when combined with carboplatin and paclitaxel. A randomized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5664a825b37cb0ceef2a9190140006fe
https://europepmc.org/articles/PMC4923331/
https://europepmc.org/articles/PMC4923331/
Autor:
Phil A. Hart, Zobeida Cruz-Monserrate, William E. Fisher, Gregory B. Lesinski, Darwin L. Conwell, Massimo Raimondo, Hanno Steen, Mark Topazian
Publikováno v:
The American journal of gastroenterology. 111(9)
Pancreatic secretions have an important role in the regulation of a normal nutritional state but can be altered owing to a variety of pathophysiological mechanisms in the context of exocrine pancreatic disease. The development of an endoscopic techni