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Autor:
Vesna Vetma, Kristin M. Riching, Satomi Imaide, Marjeta Urh, Claire Whitworth, Chiara Maniaci, Angus D. Cowan, Nicole Trainor, Sarah D. Mahan, Alessio Ciulli, Andrea Testa, Nancy Murphy, Conner Craigon, Kwok-Ho Chan, Nikolai Makukhin, Scott J. Hughes, Danette L. Daniels
Publikováno v:
Nature chemical biology
Bivalent proteolysis-targeting chimeras (PROTACs) drive protein degradation by simultaneously binding a target protein and an E3 ligase and forming a productive ternary complex. We hypothesized that increasing binding valency within a PROTAC could en
Autor:
Cleophas Cheruiyot, Antje D. Ebert, Jonathan Bodenschatz, Ruheen Wali, Michael Habeck, Andreas Janshoff, Hang Xu, Gerd Hasenfuss
Publikováno v:
FEBS Letters. 595:2544-2557
We developed an integrated platform for analysis of parameterized data from human disease models. We report a non-negative blind deconvolution (NNBD) approach to quantify calcium (Ca2+ ) handling, beating force and contractility in human-induced plur
Autor:
Ya-Yu Zhao, Chen-Chun Wang, Jia-Lu Ying, Xue Chen, Hong-Bo Jin, Cheng-Cheng Yang, Xin-Yao Yin, Yi-Chi Lu, Pan Du
Publikováno v:
Biochemical and Biophysical Research Communications. 568:103-109
At present, stem cell transplantation has a significant therapeutic effect on spinal cord injury (SCI), however, it is still challenging for the seed cells selection. In this study, in order to explore cells with wide neural repair potentials, we sel
Publikováno v:
Biochemical and Biophysical Research Communications. 568:76-82
Medulloblastoma, the most common malignant brain tumor in children, consists of four molecular subgroups WNT, SHH, Group 3, and Group 4. Group 3 has the worst survival rate among the four subgroups and is characterized by the expression of retina-spe
Autor:
Xiao Qian Chen, Shang Bin Yu, Song Lin Yin, Guo Qiang Liu, Feng Hu, Feng Liu, Chun Yang Li, Xiao Hong Xu, Ting Ting Zhang
Publikováno v:
Biochemical and Biophysical Research Communications. 569:1-9
Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor without curable therapy. Surgical resection remains the first choice of patients with GBM but tumors relapse rapidly even combined with conventional chemoradiotherapy. The
Publikováno v:
Biochemical and Biophysical Research Communications. 568:89-94
Manganese (Mn), even though an essential trace element, causes neurotoxicity in excess. In adults, over-exposure to Mn causes clinical manifestations, including dystonia, progressive bradykinesia, disturbance of gait, slurring, and stuttering of spee
Autor:
Elias Georges, Georgia Limniatis
Publikováno v:
Biochemical and Biophysical Research Communications. 570:148-153
P-glycoprotein, member of the B-subfamily of the ATP-binding cassette (ABC) superfamily (e.g., ABCB1), has been demonstrated to confer resistance to clinically relevant anticancer drugs. Paradoxically, ABCB1-expressing multidrug resistant (MDR) cells
Publikováno v:
Biochemical and Biophysical Research Communications. 568:30-36
Autophagy, the process of lysosomal degradation of biological materials within cells, is often halted abnormally in proteopathies, such as tauopathy and amyloidopathy. Thus, autophagy regulators that rescue dysregulated autophagy have great potential
Autor:
Tomoyuki Aoyama, Taishi Akimoto, Daisuke Kyuno, Taro Murakami, Hiroshi Kitajima, Hiromu Suzuki, Kumi Takasawa, Makoto Osanai, Kazufumi Magara, Akira Takasawa, Yusuke Ono
Publikováno v:
Biochemical and Biophysical Research Communications. 565:36-42
Aberrant expression of tight junction proteins has recently been focused on in the cancer research field. We previously showed that claudin-1 is aberrantly expressed from an early stage of uterine cervical adenocarcinoma and contributes to malignant
Publikováno v:
Biochemical and Biophysical Research Communications. 567:131-137
Our previous research suggested the presence of a novel SETDB1-mediated FosB pathway that could be responsible for the regulation of cell proliferation and invasiveness during anticancer treatments. In this study, we prepared FosB knock-out (FosB-KO)