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Autor:
Elias Georges, Georgia Limniatis
Publikováno v:
Biochemical and Biophysical Research Communications. 570:148-153
P-glycoprotein, member of the B-subfamily of the ATP-binding cassette (ABC) superfamily (e.g., ABCB1), has been demonstrated to confer resistance to clinically relevant anticancer drugs. Paradoxically, ABCB1-expressing multidrug resistant (MDR) cells
Publikováno v:
Biochemical and Biophysical Research Communications. 567:56-62
Human circadian rhythm refers to the intrinsic ∼24-h oscillation that regulates biological processes to adapt to environments. Disruption of rhythmicity causes mitochondrial dysfunction, changes metabolism, and is associated with neurodegenerative
Autor:
Yehan Fang, Wentao Cai, Yibo Li, Mingxia Lin, Daolu Zhan, Helin Yang, Jian Chen, Jian Liu, Guangji Wang
Publikováno v:
Biochemical and Biophysical Research Communications. 566:16-23
With the aggravation of global aging, the rapid rise in the obesity rate, and the increasing number of patients with intervertebral disc degeneration (IDD), the principles and mechanism of this disease remain unclear. This study explored the molecula
Publikováno v:
Biochemical and Biophysical Research Communications. 567:125-130
Differentiated mammary epithelial cells are responsible for milk synthesis during lactation, supporting early postnatal life in mammals. These cells are found in the terminal alveoli of a secretory epithelium, which is surrounded by myoepithelial cel
Autor:
Hanteng Yang, Benyuan Deng, Shuze Zhang, Changjiang Luo, Gengyuan Zhang, Ruiying Luo, Yun Wang
Publikováno v:
Biochemical and Biophysical Research Communications. 561:80-87
Emerging evidence suggests that microRNAs (miRNAs) participate in hepatocellular carcinoma (HCC) progression. Nevertheless, the mechanism of miR-7-5p in HCC cells has not been researched. In the research, the underlying biological function of miR-7-5
Publikováno v:
Acta Biochimica et Biophysica Sinica
SUMOylation of proteins regulates cell behaviors and is reversibly removed by small ubiquitin-like modifier (SUMO)-specific proteases (SENPs). The SENP family member SENP3 is involved in SUMO2/3 deconjugation and has been reported to sense cell stres
Autor:
Zhihui Lu, Jiaming Zhu, Jie Teng, Yi Fang, Yiran Liang, Yan Dai, Nana Song, Xiaoqiang Ding, Hong Liu
Publikováno v:
Biochemical and Biophysical Research Communications. 559:48-55
Podocyte injury is associated with albuminuria and the progression of diabetic nephropathy (DN). MiR-34a, a p53-regulated miRNA, directly targets SIRT1 and contributed to DN progression. MiR-34a represses SIRT1 to activate p53 and establish a positiv
Publikováno v:
Biochemical and Biophysical Research Communications. 559:141-147
Diabetic nephropathy (DN) is the primary cause of end-stage renal disease, and renal tubular cell dysfunction contributes to the pathogenesis of many kidney diseases. Our previous study demonstrated that dual-specificity protein phosphatase 1 (DUSP1)
Publikováno v:
Biochemical and Biophysical Research Communications. 559:8-14
Background Long non-coding RNAs (lncRNAs) play vital roles in human diseases, including sepsis-induced acute kidney injury (AKI). Here, we aimed to investigate the functions of lncRNA NKILA in sepsis-engendered AKI. Methods HK2 cells stimulated with
Publikováno v:
Biochemical and Biophysical Research Communications. 556:99-105
To develop anti-ischemic stroke drugs with higher blood-brain barrier (BBB) penetrating capability and neuroprotective activity, a series of hybrid compounds containing edaravone analogue and 3-n-butylphthalide (NBP) ring-opened derivatives were synt