Zobrazeno 1 - 10
of 18 474
pro vyhledávání: ''
Autor:
Edith Borcoman, Christophe Le Tourneau, Grégoire Vuagniaux, Sébastien Vergez, Jérôme Sarini, Neus Baste, Philippe Rochaix, Franck Brichory, Annick Menetrey, Stéphane Temam, Claudio Zanna, Elisabeth Rouits, Carlos Gomez-Roca, Jean-Pierre Delord, Daniela Purcea, Caroline Hoffmann, Caroline Even, Bruno Gavillet
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 1, Pp 55-62 (2022)
Clinical and Translational Science
Clinical and Translational Science
Inhibitor of apoptosis proteins (IAPs) regulate apoptosis and modulate NF‐κB signaling thereby driving expression of genes involved in immune/inflammatory responses. The orally available IAP antagonist Debio 1143 has potential to enhance tumor res
Autor:
Gulbu Uzel, Hye Sun Kuehn, Christina Tatsi, Thomas A. Fleisher, Yan Su, Julie E. Niemela, Jennifer Stoddard, Maya Lodish, Sergio D. Rosenzweig, Warren J. Leonard, Constantine A. Stratakis, SuJin Hwang, Rosanne Spolski, Steven M. Holland
Publikováno v:
J Allergy Clin Immunol
BACKGROUND: Pediatric endogenous Cushing syndrome is mainly caused by pituitary corticotropin-producing adenomas and most glucocorticoid-dependent effects progressively regress upon tumor removal. Endogenous Cushing syndrome reproduces long-term high
Publikováno v:
Biomedical Journal. 44:694-708
Background Pancreatic cancer is one of the most notorious cancers and is known for its highly invasive characteristics, drug resistance, and metastatic progression. Unfortunately, resistance towards gemcitabine develops in many with advanced pancreat
Publikováno v:
Virulence, Vol 12, Iss 1, Pp 968-980 (2021)
Virulence
article-version (VoR) Version of Record
Virulence
article-version (VoR) Version of Record
Thousands of human deaths occur annually due to Japanese encephalitis (JE), caused by Japanese encephalitis virus. During the virus infection of the central nervous system, reactive gliosis, uncontrolled inflammatory response, and neuronal cell death
Autor:
Tatiana Gamez, Carlos Vargas, Christian Rolfo, Pilar Archila, Luis Corrales, Oscar Arrieta, Claudio Martin, Jorge Otero, C. Sotelo, Hernán Carranza, Juan Esteban Garcia-Robledo, D. Mayorga, Luisa Ricaurte, Camila Ordóñez-Reyes, Lucia Zatarain Barron, L. Rojas, Rafael Rosell, Luis Mas, Alejandro Ruiz-Patiño, Maritza Bermudez, July Rodriguez, J. Ávila, Andrés F. Cardona, Gonzalo Recondo, Feliciano Barrón
Publikováno v:
Repositorio U. El Bosque
Universidad El Bosque
instacron:Universidad El Bosque
Universidad El Bosque
instacron:Universidad El Bosque
La activación de BIM es esencial para la apoptosis desencadenada por el inhibidor de la tirosina quinasa (TKI) del receptor del factor de crecimiento epidérmico (EGFR) en el cáncer de pulmón de células no pequeñas (CPCNP) con mutación de EGFR.
Autor:
Kenneth K.-S. Ng, A. Iqbal, Mark G. Kris, Maria E. Arcila, Helena A. Yu, Linda Ahn, Jia Luo, Yosef Tobi, Sara A. Hayes, Alex Makhnin, Gregory J Riely
Publikováno v:
JCO Precision Oncology. :55-64
PURPOSE Inhibition of the MEK/ERK pathway is critical for Bcl-2-like protein 11 (BIM)-mediated epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI)-induced apoptosis, and dysregulation of this pathway may be a mechanism of acquired
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 11, Pp 3553-3566 (2021)
Rescuing cells from stress damage emerges a potential therapeutic strategy to combat myocardial infarction. Protocatechuic aldehyde (PCA) is a major phenolic acid in Chinese herb Danshen (Salvia miltiorrhiza root). This study investigated whether PCA
Autor:
Mandy L. Ford, Yini Sun, Jennifer M. Robertson, Aneesh K. Mehta, Marvi Tariq, Scott M. Krummey, Christina R. Hartigan, He Sun, Ching wen Chen
Publikováno v:
Am J Transplant
Belatacept confers increased patient and graft survival in renal transplant recipients relative to calcineurin inhibitors, but is associated with an increased rate of acute rejection. Recent immunophenotypic studies comparing pre-transplant T cell ph
Autor:
Chenghao Bi, Yidan Zhang, Hui Liu, Yubo Li, Yanjun Zhang, Lijuan Xie, Huan Zhao, Yu Yuan, Pengwei Zhuang
Publikováno v:
Toxicology Letters. 349:145-154
Cutaneous eruptions caused by the combination of Chinese and Western medicine have attracted widespread attention; however, the underlying mechanism remains unclear. This study aimed to evaluate the potential mechanism of cutaneous eruptions in vivo
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 10, Pp 3262-3271 (2021)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Tumor metastasis is responsible for chemotherapeutic failure and cancer-related death. Moreover, circulating tumor cell (CTC) clusters play a pivotal role in tumor metastasis. Herein, we develop cancer-specific calcium nanoregulators to suppress the