Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Richard A, Koup"'
Autor:
Eirini Moysi, Perla M. Del Rio Estrada, Fernanda Torres-Ruiz, Gustavo Reyes-Terán, Richard A. Koup, Constantinos Petrovas
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, Vol 12 (2021)
CD4 T cells are key mediators of adaptive immune responses during infection and vaccination. Within secondary lymphoid organs, helper CD4 T cells, particularly those residing in germinal centers known as follicular helper T cells (Tfh), provide criti
Autor:
Michael Chambers, Safiatou Doumbo, Sarah F. Andrews, Peter D. Crompton, Peter D. Sun, Eric O. Long, Shanping Li, Mary E. Peterson, Richard A. Koup, Boubacar Traore, Kristin L. Boswell, Adrian B. McDermott, Joshua Tan, Aissata Ongoiba, Kassoum Kayentao, Jinghua Lu, Kazutoyo Miura, Christopher M. Tipton, Ababacar Diouf, Carole A. Long, Padmapriya Sekar, Christine S. Hopp, Silvia Portugal, Jeff Skinner
Publikováno v:
The Journal of Experimental Medicine
The role of IgM in human malaria is unclear. In a cohort study in Mali, Hopp et al. find that malaria-specific memory B cells are disproportionally IgM in children, are activated during acute malaria, and produce IgM that inhibits malaria parasite gr
Publikováno v:
Methods. 154:118-124
Bispecific (bs) antibodies (Abs, bsAbs) are engineered immunoglobulins that contain two different antigen-binding sites in one molecule. bsAbs can be divided in two molecular formats; the IgG-like and non-IgG like. The structural elements of each for
Publikováno v:
Retrovirology, Vol 15, Iss 1, Pp 1-10 (2018)
Retrovirology
Retrovirology
The induction of HIV-1-specific antibodies that can neutralize a broad number of isolates is a major goal of HIV-1 vaccination strategies. However, to date no candidate HIV-1 vaccine has successfully elicited broadly neutralizing antibodies of suffic
Autor:
Lucio Gama, Richard A. Koup
Publikováno v:
Annual Review of Medicine. 69:409-419
Broadly neutralizing antibodies (bNAbs) have been evaluated as promising agents in the fight against infectious diseases. HIV-1-specific bNAbs, in particular, have been tested in both preventive and therapeutic modalities. Multiple bNAbs have been is
Autor:
Shannon Grant, Allan C. deCamp, Chenchen Yu, Susan Buchbinder, Edith Swann, Guido Ferrari, Barney S. Graham, Lindsay N. Carpp, Richard A. Koup, Shelly Karuna, Nicole Frahm, Holly Janes, Ian Frank, Mark J. Mulligan, Youyi Fong, Kelly E. Seaton, Robert T. Bailer, Xiaoying Shen, Barton F. Haynes, Georgia D. Tomaras, Magda Sobieszczyk, Richard M. Novak, M. Juliana McElrath, Vicki C Ashley, Michael C. Keefer, Spyros A. Kalams, Edwin DeJesus, David C. Montefiori, Aaron Deal, Peter B. Gilbert, Marcella Sarzotti-Kelsoe, Scott M. Hammer
Publikováno v:
The Journal of Infectious Diseases
Background HVTN 505 was a human immunodeficiency virus type 1 (HIV-1) preventive vaccine efficacy trial of a DNA/recombinant adenovirus serotype 5 (rAd5) vaccine regimen. We assessed antibody responses measured 1 month after final vaccination (month
Autor:
Zachary Mankoff, Ronnie Wei, Dennis R. Burton, Krisha McKee, Dana M. Lord, Richard A. Koup, Christian Lange, Wulf Dirk Leuschner, Keyun Wang, Mario Roederer, Stephen D. Schmidt, Tongqing Zhou, Dan H. Barouch, Rebecca Sendak, Lawrence J. Tartaglia, Sijy O'Dell, Zhi Yong Yang, Misook Choe, Robert T. Bailer, Lan Wu, John R. Mascola, Mangaiarkarasi Asokan, Young Do Kwon, Amarendra Pegu, Ercole Rao, Ling Xu, Mark Connors, Peter D. Kwong, Jochen Kruip, Xuejun Chen, John-Paul Todd, Gejing Deng, Mark K. Louder, Gary J. Nabel, Nicole A. Doria-Rose, Christian Beil, Jochen Beninga
Publikováno v:
Science. 358:85-90
A triple threat for HIV The HIV virus continually evolves tricks to evade elimination by the host. Prevention and a cure will likely rely on broadly neutralizing antibodies that can recognize and conquer multiple viral strains or subtypes. Xu et al.
Autor:
Florian Krammer, Sarah F. Andrews, Kenta Matsuda, Peter D. Kwong, Stephen A. Migueles, Adam K. Wheatley, Sarah Stuccio, Sam Darko, Marc Gurwith, Mark Connors, Jinghe Huang, Baoshan Zhang, Robert T. Bailer, Trevor Griesman, M. Gordon Joyce, Zizhang Sheng, Jeff Alexander, Alyssa A. Pullano, Elise Ishida, Jason Plyler, Yaroslav Tsybovsky, Byong H. Kang, Teddy John Wohlbold, Hana Golding, Tongqing Zhou, Kwanyee Leung, Richard A. Koup, Jon Smith, Adrian B. McDermott, Surender Khurana, Lyuba Bolkhovitinov, Crystal S.F. Cheung, Cinque Soto, Yongping Yang, Yicheng Guo, Lawrence Shapiro, Veronika Chromikova, C. Jason Liang, Sandeep Narpala, April Poole, Alberto Cagigi
Publikováno v:
Science Immunology. 4
Induction of an antibody response capable of recognizing highly diverse strains is a major obstacle to the development of vaccines for viruses such as HIV and influenza. Here, we report the dynamics of B cell expansion and evolution at the single-cel
Autor:
Celia Santos, Peter D. Kwong, Wing-Pui Kong, Baoshan Zhang, Yi Zhang, Amy Ransier, Robert T. Bailer, Kwanyee Leung, Richard A. Koup, Sam Darko, Tatsiana Bylund, Sandeep N. Narpala, Hadi M. Yassine, Ulrich Baxa, Cinque Soto, Rebecca A. Gillespie, M. Gordon Joyce, Julie E. Ledgerwood, Xueling Wu, Lawrence Shapiro, Madhu Prabhakaran, Adam K. Wheatley, Ivelin S. Georgiev, Kanta Subbarao, Chen-Hsiang Shen, Adrian B. McDermott, Gwo-Yu Chuang, Yumiko Matsuoka, Mangaiarkarasi Asokan, James C. Mullikin, Yaroslav Tsybovsky, Lingshu Wang, Paul V. Thomas, Jeffrey C. Boyington, Aliaksandr Druz, James R R Whittle, Daniel C. Douek, Eun Sung Yang, Mario Roederer, Masaru Kanekiyo, John R. Mascola, Barney S. Graham, Christopher R. Lees
Publikováno v:
Cell. 166:609-623
Antibodies capable of neutralizing divergent influenza A viruses could form the basis of a universal vaccine. Here, from subjects enrolled in an H5N1 DNA/MIV-prime-boost influenza vaccine trial, we sorted hemagglutinin cross-reactive memory B cells a
Autor:
Melvin N. Doster, Mario Roederer, Barbara K. Felber, David C. Montefiori, Maria Omsland, Luca Schifanella, Monica Vaccari, George N. Pavlakis, Dallas R. Brown, Hung V. Trinh, Mangala Rao, David Venzon, Kathryn E. Foulds, Donald N. Forthal, Giacomo Gorini, Margherita Rosati, Isabela Silva de Castro, Brandon F. Keele, Rafick Pierre Sekaly, Massimiliano Bissa, Slim Fourati, Dai Fujikawa, Richard A. Koup, Xiaoying Shen, Namal P.M. Liyanage, Katherine McKinnon, Johannes S. Gach, Karissa J Muñoz, Genoveffa Franchini, Veronica Galli, Shari N. Gordon, Georgia D. Tomaras, Marcus P. Wong
Publikováno v:
Nature medicine, vol 24, iss 6
Qualitative differences in the innate and adaptive responses elicited by different HIV vaccine candidates have not been thoroughly investigated. We tested the ability of the Aventis Pasteur live recombinant canarypox vector (ALVAC)–SIV, DNA–SIV a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::548ef2b89c1676f36805f8df750a071e
https://europepmc.org/articles/PMC5992093/
https://europepmc.org/articles/PMC5992093/