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Autor:
Serena K. Wolfe, David J. Beebe, Jamie M. Sperger, Jennifer L. Schehr, Erika Heninger, Toni K. Choueri, Xiao X. Wei, Joshua A. Desotelle, Charlotte N. Stahlfeld, Waddah Arafat, Joshua M. Lang, John A. Steinharter, Hamid Emamekhoo, Rana R. McKay, E. Jason Abel, Anupama Singh, Matthew C. Mannino, Tamara S. Rodems, David J. Niles, Rory M. Bade, Benjamin K. Gibbs
Publikováno v:
Molecular Oncology, Vol 15, Iss 9, Pp 2330-2344 (2021)
Molecular Oncology
Molecular Oncology
Although therapeutic options for patients with advanced renal cell carcinoma (RCC) have increased in the past decade, no biomarkers are yet available for patient stratification or evaluation of therapy resistance. Given the dynamic and heterogeneous
Autor:
Tadayoshi Okimoto, Takahiro Hiratsuka, Shusaku Kurogi, Masafumi Inomata, Tomohisa Uchida, Daisuke Kakisako, Teijiro Hirashita, Masatsugu Moriyama, Chisato Nakada, Yoshiyuki Tsukamoto, Naoki Hijiya, Yuka Hirashita, Tsuyoshi Etoh, Tomonori Akagi, Masaaki Kodama, Yoshitake Ueda, Kazuhiro Mizukami, Yoko Kudo, Koichi Honda, Kazunari Murakami, Hidefumi Shiroshita
Publikováno v:
Laboratory Investigation. 101:1036-1047
Mutations in RAS or BRAF are associated with poor prognosis and resistance to epidermal growth factor receptor (EGFR)-targeted therapy in colorectal cancer (CRC). Despite their common ability to activate downstream genes such as MEK and ERK, the ther
Autor:
Eric S. Geanes, Sean M. Holloran, Anuradha Roy, Olivia K. Provance, Sumedha Gunewardena, Christy R. Hagan, Scott Weir, Asona Lui, Joan Lewis-Wambi
Publikováno v:
Cancer Lett
Overexpression of interferon induced transmembrane protein-1 (IFITM1) enhances tumor progression in multiple cancers, but its role in triple-negative breast cancer (TNBC) is unknown. Here, we explore the functional significance and regulation of IFIT
Publikováno v:
Cancer Medicine, Vol 10, Iss 16, Pp 5545-5556 (2021)
Cancer Medicine
Cancer Medicine
Epigenetic regulation is important for cancer tumor metastasis and progression, including lung and liver cancer. However, the mechanism of epigenetic regulation in liver cancer leaves much to be discussed. According to a previous study, p300/CBP‐as
Autor:
Wenjie Gao, Bo Gao, Xianjian Qiu, Dongsheng Huang, Jincheng Qiu, Pengfei Li, Hang Zhou, Zhancheng Liang, Zhihuai Deng, Wenjun Hu, Tongzhou Liang, Anjing Liang, Shaoguang Li, Taiqiu Chen
Publikováno v:
Mediators of Inflammation
Mediators of Inflammation, Vol 2021 (2021)
Mediators of Inflammation, Vol 2021 (2021)
Intervertebral disc degenerative disease (IDD) is the most common degenerative spine disease, which leads to chronic low back pain and symptoms in the lower extremities. In this study, we found that RORα, a member of the retinoid-related orphan rece
Autor:
Ben Liu, Yufan Ying, Xueyou Ma, Xiao Wang, Xiangyi Zheng, Weiyu Wang, Liping Xie, Bo Xie, Haiyun Xie, Jiangfeng Li, Jian Wu, Jiajie Fang, Shiming Chen
Publikováno v:
Cell Death and Disease, Vol 12, Iss 8, Pp 1-12 (2021)
Cell Death & Disease
Cell Death & Disease
Emerging discoveries of dynamic and reversible N6-methyladenosine (m6A) modification on RNA in mammals have revealed the key roles of the modification in human tumorigenesis. As known m6A readers, insulin-like growth factor 2 mRNA-binding proteins (I
Publikováno v:
Cell Death and Disease, Vol 12, Iss 8, Pp 1-9 (2021)
Cell Death & Disease
Cell Death & Disease
MicroRNA (miR)-361-5p has been studied to suppress gliomas development. Based on that, an insight into the regulatory mechanism of miR-361-5p in gliomas was supplemented from ubiquitin protein ligase E3 component N-recognin 5 (UBR5)-mediated ubiquiti
Autor:
Liqin Xu, Jia Fan, Yu Zhong, Miaomiao Jiang, Xiao-Rui Zhou, Yong Hou, Geng Liu, Min Du, Guibo Li, Shuang-Jian Qiu, Yuan Ji, Sun Yunfan, Xiangdong Wang, Bo Hu, Ashley R. Dennison, Sheng Liu, Ze-Fan Zhang, Qichao Yu, Xiaoyun Huang, Yang Xu, Ying-Hong Shi, David H. Peng, Wen-Yuan Chung, Kai-Qian Zhou, Nannan Li, Wei Guo, Liang Wu, Jian Zhou, Xin-Rong Yang, Hui-Chuan Sun, Michael Dean, Shiping Liu, Zhikun Zhao
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications
Little is known about the transcriptomic plasticity and adaptive mechanisms of circulating tumor cells (CTCs) during hematogeneous dissemination. Here we interrogate the transcriptome of 113 single CTCs from 4 different vascular sites, including hepa
Autor:
Maria Jenvin Støen, Sigve Andersen, Ana Paola Lombardi, Lise Martine Ingebriktsen, Thomas Karsten Kilvær, Tom Donnem, Elin Richardsen, Lill-Tove Busund, Mehrdad Rakaee, Roy M. Bremnes, Mona Irene Pedersen
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports
MicroRNAs (miRs) are small non-coding RNA molecules, which are involved in the development of various malignancies, including prostate cancer (PCa). miR-17-5p is considered the most prominent member of the miR-17-92 cluster, with an essential regulat
Autor:
Christian Röder, Sandra Krüger, Christine Halske, Anna Trauzold, Jan-Paul Gundlach, Anna Willms, Franka Maria Schlegel, Holger Kalthoff, Charlotte Hauser, Thomas E. Becker, Christoph Röcken
Publikováno v:
Journal of Cancer Research and Clinical Oncology
Purpose HMGA2 has frequently been found in benign as well as malignant tumors and a significant association between HMGA2 overexpression and poor survival in different malignancies was described. In pancreatic ductal adenocarcinoma (PDAC), nuclear HM