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Autor:
Takamichi Igarashi, Tetsunari Oyama, Kouki Hoshino, Gantumur Dolgormaa, Yuki Shimoda, Kenichiro Araki, Norifumi Harimoto, Norihiro Ishii, Norio Kubo, Kei Hagiwara, Hiroshi Saeki, Takahiro Yamanaka, Mariko Tsukagoshi, Takehiko Yokobori, Ryo Muranushi, Akira Watanabe, Batbayar Chingunjav, Ken Shirabe, Rie Sano
Publikováno v:
Cancer Science
CKLF‐like MARVEL transmembrane domain–containing protein 6 (CMTM6) maintains membrane PD‐L1 expression by controlling its endosomal recycling. However, in patients with hepatocellular carcinoma (HCC), the correlation among CMTM6, B7 family liga
Autor:
Kun Zhang, Juntong Wang, Aiwu You, Jun Li, Yuyan Zhang, Guomin Rao, Xuehua Ge, Xuan Liu, Jingshun Gu, Dongchun Wang
Publikováno v:
Genes & Genomics. 43:1157-1165
Gliomas are common malignant tumors in the nervous system, known for poor prognosis and low survival rate. This study aims to explore functions of miR-137 in glioma progression and identify messenger RNAs (mRNA) regulated by miR-137, which provides n
Publikováno v:
Bioscience, Biotechnology, and Biochemistry. 85:1839-1845
DUSP4 is considered as an oncogenic gene. However, the effect of DUSP4 on the carcinogenesis of clear cell Renal cell carcinoma (CCRCC) is still unclear. In this study, DUSP4 mRNA levels were significantly increased in CCRCC tissues and cell lines. F
Autor:
Stephane Ferretti, Sébastien Jeay, Ensar Halilovic, Claire Fabre, Laurence Van Bree, Christophe Meille, Jens Wuerthner, Florence Hourcade-Potelleret, Sebastian Bauer, Reinhard Dummer, Philippe A. Cassier, Astrid Jullion, George D. Demetri, Nelson Guerreiro, Daniel Shao-Weng Tan
Publikováno v:
British Journal of Cancer
Background CGM097 inhibits the p53-HDM2 interaction leading to downstream p53 activation. Preclinical in vivo studies support clinical exploration while providing preliminary evidence for dosing regimens. This first-in-human phase I study aimed at as
Autor:
Shusuke Akamatsu, Kei Mizuno, Takayuki Sumiyoshi, Eijiro Nakamura, Noriaki Utsunomiya, Osamu Ogawa, Toshinari Yamasaki, Hiromasa Sakamoto, Masashi Takeda
Publikováno v:
Cancer Science
The therapeutic landscape of metastatic clear cell renal cell carcinoma (ccRCC) has rapidly expanded, and there is an urgent need to develop noninvasive biomarkers that can select an optimal therapy or evaluate the response in real time. To evaluate
Publikováno v:
Cancer Investigation. 39:559-570
The study evaluated whether SPP1/osteopontin (OPN) splice variants are differentially expressed in nonmelanoma skin cancer compared to normal skin. The absolute number of mRNA molecules of OPN-a predominated in normal skin and nonmelanoma skin cancer
Autor:
Masayuki Ohtsuka, Katsunori Furukawa, Yoji Miyahara, Satoshi Kuboki, Satoshi Tomizawa, Mamoru Takada, Tsukasa Takayashiki, Shigetsugu Takano, Kosuke Sasaki
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-16 (2021)
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research : CR
Background Recent studies indicate that complement plays pivotal roles in promoting or suppressing cancer progression. We have previously identified C4b-binding protein α-chain (C4BPA) as a serum biomarker for the early detection of pancreatic ducta
Autor:
Shauli Talmor, Ignacio Mastandrea, Tova Waks, Zelig Eshhar, Liat Rousso-Noori, Dinorah Friedmann-Morvinski, Tambet Teesalu, Maarja Haugas, Luis Álvarez-Vallina, Anat Levin
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Rousso-Noori, L, Mastandrea, I, Talmor, S, Waks, T, Globerson Levin, A, Haugas, M, Teesalu, T, Alvarez-Vallina, L, Eshhar, Z & Friedmann-Morvinski, D 2021, ' P32-specific CAR T cells with dual antitumor and antiangiogenic therapeutic potential in gliomas ', Nature Communications, vol. 12, no. 1, 3615 . https://doi.org/10.1038/s41467-021-23817-2
Nature Communications
Rousso-Noori, L, Mastandrea, I, Talmor, S, Waks, T, Globerson Levin, A, Haugas, M, Teesalu, T, Alvarez-Vallina, L, Eshhar, Z & Friedmann-Morvinski, D 2021, ' P32-specific CAR T cells with dual antitumor and antiangiogenic therapeutic potential in gliomas ', Nature Communications, vol. 12, no. 1, 3615 . https://doi.org/10.1038/s41467-021-23817-2
Nature Communications
Glioblastoma is considered one of the most aggressive malignancies in adult and pediatric patients. Despite decades of research no curative treatment is available and it thus remains associated with a very dismal prognosis. Although recent pre-clinic
Autor:
Angang Yang, Baile Zuo, Wenjin Xi, Rui Zhang, Wei-Hong Wen, Zhangyan Guo, Lin-Tao Jia, Weimiao Li, Guoxu Zheng
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-15 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Despite the successful use of the humanized monoclonal antibody trastuzumab (Herceptin) in the clinical treatment of human epidermal growth factor receptor 2 (HER2)-overexpressing breast cancer, the frequently occurring drug resistance remains to be
Autor:
Qiyuan Li, Chuanhui Lu, Chunlin Ke, Fakun Huang, Rongmu Xia, Yanjun Mi, Yanru Xiao, Jiayi Li, Jun You
Publikováno v:
Oncogene
Emerging evidences suggest that long noncoding RNA (lncRNA) plays a vital role in tumorigenesis and cancer progression. Here, the aim of this study is to investigate the biological function of long intervening noncoding RNA Linc00284 in colorectal ca