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Autor:
Serena K. Wolfe, David J. Beebe, Jamie M. Sperger, Jennifer L. Schehr, Erika Heninger, Toni K. Choueri, Xiao X. Wei, Joshua A. Desotelle, Charlotte N. Stahlfeld, Waddah Arafat, Joshua M. Lang, John A. Steinharter, Hamid Emamekhoo, Rana R. McKay, E. Jason Abel, Anupama Singh, Matthew C. Mannino, Tamara S. Rodems, David J. Niles, Rory M. Bade, Benjamin K. Gibbs
Publikováno v:
Molecular Oncology, Vol 15, Iss 9, Pp 2330-2344 (2021)
Molecular Oncology
Molecular Oncology
Although therapeutic options for patients with advanced renal cell carcinoma (RCC) have increased in the past decade, no biomarkers are yet available for patient stratification or evaluation of therapy resistance. Given the dynamic and heterogeneous
Autor:
Eric S. Geanes, Sean M. Holloran, Anuradha Roy, Olivia K. Provance, Sumedha Gunewardena, Christy R. Hagan, Scott Weir, Asona Lui, Joan Lewis-Wambi
Publikováno v:
Cancer Lett
Overexpression of interferon induced transmembrane protein-1 (IFITM1) enhances tumor progression in multiple cancers, but its role in triple-negative breast cancer (TNBC) is unknown. Here, we explore the functional significance and regulation of IFIT
Publikováno v:
Cancer Medicine, Vol 10, Iss 16, Pp 5545-5556 (2021)
Cancer Medicine
Cancer Medicine
Epigenetic regulation is important for cancer tumor metastasis and progression, including lung and liver cancer. However, the mechanism of epigenetic regulation in liver cancer leaves much to be discussed. According to a previous study, p300/CBP‐as
Autor:
Christian Röder, Sandra Krüger, Christine Halske, Anna Trauzold, Jan-Paul Gundlach, Anna Willms, Franka Maria Schlegel, Holger Kalthoff, Charlotte Hauser, Thomas E. Becker, Christoph Röcken
Publikováno v:
Journal of Cancer Research and Clinical Oncology
Purpose HMGA2 has frequently been found in benign as well as malignant tumors and a significant association between HMGA2 overexpression and poor survival in different malignancies was described. In pancreatic ductal adenocarcinoma (PDAC), nuclear HM
Autor:
Takamichi Igarashi, Tetsunari Oyama, Kouki Hoshino, Gantumur Dolgormaa, Yuki Shimoda, Kenichiro Araki, Norifumi Harimoto, Norihiro Ishii, Norio Kubo, Kei Hagiwara, Hiroshi Saeki, Takahiro Yamanaka, Mariko Tsukagoshi, Takehiko Yokobori, Ryo Muranushi, Akira Watanabe, Batbayar Chingunjav, Ken Shirabe, Rie Sano
Publikováno v:
Cancer Science
CKLF‐like MARVEL transmembrane domain–containing protein 6 (CMTM6) maintains membrane PD‐L1 expression by controlling its endosomal recycling. However, in patients with hepatocellular carcinoma (HCC), the correlation among CMTM6, B7 family liga
Autor:
Stephane Ferretti, Sébastien Jeay, Ensar Halilovic, Claire Fabre, Laurence Van Bree, Christophe Meille, Jens Wuerthner, Florence Hourcade-Potelleret, Sebastian Bauer, Reinhard Dummer, Philippe A. Cassier, Astrid Jullion, George D. Demetri, Nelson Guerreiro, Daniel Shao-Weng Tan
Publikováno v:
British Journal of Cancer
Background CGM097 inhibits the p53-HDM2 interaction leading to downstream p53 activation. Preclinical in vivo studies support clinical exploration while providing preliminary evidence for dosing regimens. This first-in-human phase I study aimed at as
Autor:
Shusuke Akamatsu, Kei Mizuno, Takayuki Sumiyoshi, Eijiro Nakamura, Noriaki Utsunomiya, Osamu Ogawa, Toshinari Yamasaki, Hiromasa Sakamoto, Masashi Takeda
Publikováno v:
Cancer Science
The therapeutic landscape of metastatic clear cell renal cell carcinoma (ccRCC) has rapidly expanded, and there is an urgent need to develop noninvasive biomarkers that can select an optimal therapy or evaluate the response in real time. To evaluate
Publikováno v:
Cancer Investigation. 39:559-570
The study evaluated whether SPP1/osteopontin (OPN) splice variants are differentially expressed in nonmelanoma skin cancer compared to normal skin. The absolute number of mRNA molecules of OPN-a predominated in normal skin and nonmelanoma skin cancer
Autor:
Masayuki Ohtsuka, Katsunori Furukawa, Yoji Miyahara, Satoshi Kuboki, Satoshi Tomizawa, Mamoru Takada, Tsukasa Takayashiki, Shigetsugu Takano, Kosuke Sasaki
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-16 (2021)
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research : CR
Background Recent studies indicate that complement plays pivotal roles in promoting or suppressing cancer progression. We have previously identified C4b-binding protein α-chain (C4BPA) as a serum biomarker for the early detection of pancreatic ducta
Autor:
Chien-Liang Liu, Yuan-Ching Chang, Chun-Yi Wu, Ming-Jen Chen, Wen-Chien Huang, Shih-Ping Cheng, Chi-Hsin Lin, Jiunn-Chang Lin
Publikováno v:
Investigational New Drugs. 39:1493-1506
Background Human 3β-hydroxysteroid dehydrogenase type 1 (HSD3B1) is an enzyme associated with steroidogenesis, however its' role in hepatocellular carcinoma (HCC) biology is unknown. Trilostane is an inhibitor of HSD3B1 and has been tested as a trea