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Autor:
Serena K. Wolfe, David J. Beebe, Jamie M. Sperger, Jennifer L. Schehr, Erika Heninger, Toni K. Choueri, Xiao X. Wei, Joshua A. Desotelle, Charlotte N. Stahlfeld, Waddah Arafat, Joshua M. Lang, John A. Steinharter, Hamid Emamekhoo, Rana R. McKay, E. Jason Abel, Anupama Singh, Matthew C. Mannino, Tamara S. Rodems, David J. Niles, Rory M. Bade, Benjamin K. Gibbs
Publikováno v:
Molecular Oncology, Vol 15, Iss 9, Pp 2330-2344 (2021)
Molecular Oncology
Molecular Oncology
Although therapeutic options for patients with advanced renal cell carcinoma (RCC) have increased in the past decade, no biomarkers are yet available for patient stratification or evaluation of therapy resistance. Given the dynamic and heterogeneous
Publikováno v:
Journal of Cellular and Molecular Medicine
Mounting data have shown that long non‐coding RNAs (lncRNAs) widely participate in tumour initiation, development, progression and glycolysis in a variety of tumours. However, the clinical prognosis and molecular mechanisms of TMEM161B‐AS1 in oes
Autor:
Zekuan Xu, Yiwen Xia, Zhe Xuan, Li Xie, Tianlu Jiang, Sen Wang, Zhongyuan He, Shengkui Qiu, Linjun Wang, Jialun Lv, Ying Li, Bowen Li
Publikováno v:
Molecular Cancer, Vol 20, Iss 1, Pp 1-18 (2021)
Molecular Cancer
Molecular Cancer
Background A novel type of noncoding RNA, circRNA has been reported to participate in the occurrence and development of diseases through many mechanisms. The MAPK pathway is a common signal transduction pathway involved in cell proliferation, inflamm
Targeting CXCR2 inhibits the progression of lung cancer and promotes therapeutic effect of cisplatin
Autor:
Yuan Cheng, Xuejiao Han, Qingfang Li, Fei Mo, Xiawei Wei, Yuquan Wei, Houhui Shi, Siyuan Chen
Publikováno v:
Molecular Cancer, Vol 20, Iss 1, Pp 1-21 (2021)
Molecular Cancer
Molecular Cancer
Background Drug-resistance and severe side effects of chemotherapeutic agents result in unsatisfied survival of patients with lung cancer. CXCLs/CXCR2 axis plays an important role in progression of cancer including lung cancer. However, the specific
Publikováno v:
Molecular Oncology
Molecular Oncology, Vol 15, Iss 5, Pp 1566-1583 (2021)
Molecular Oncology, Vol 15, Iss 5, Pp 1566-1583 (2021)
Esophageal squamous cell carcinoma (ESCC) is one of the most refractory malignancies worldwide. Mitogen‐activated protein kinase 3 (MAP2K3) has a contradictory role in tumor progression, and the function and expression patterns of MAP2K3 in ESCC re
Pharmaceutical immunoglobulin G impairs anti-carcinoma activity of oxaliplatin in colon cancer cells
Autor:
Yuru Shang, Christina S Mullins, Peng Gong, Brigitte Vollmar, Xianbin Zhang, Lili Lu, Dietmar Zechner, Ke Jiang, Mathias Krohn, Michael Linnebacher, Stephanie Matschos
Publikováno v:
British Journal of Cancer
Background Recent evidence proves that intravenous human immunoglobulin G (IgG) can impair cancer cell viability. However, no study evaluated whether IgG application benefits cancer patients receiving chemotherapeutics. Methods Influence of pharmaceu
Autor:
Yu-Xiang Liao, Jian Li, Jingping Liu, Chen Jin, Xin Bin Liao, Jie Zhao, Ming Wu, Bo Liu, Zhiping Zhang
Publikováno v:
Molecular Oncology, Vol 15, Iss 2, Pp 596-622 (2021)
Molecular Oncology
Molecular Oncology
Altered expression of circEPHB4, miR‐637 or SOX10 was independently associated with overall survival of glioma patients. By sponging miR‐637, circEPHB4 up‐regulated SOX10 and its target Nestin to promote stemness and self‐proliferation of gli
Autor:
Cao Yueyu, Shanshan Yu, Zeng-Guang Xu, Ma Zuan, Guangxue Wang, Xuelian Fu, Ying Lu, Qinchuan Li
Publikováno v:
Journal of Cellular and Molecular Medicine
Eukaryotic translation initiation factor 4 gamma 1 (EIF4G1), as the key component of the transcription initiation factor complex EIF4F, is significantly upregulated in multiple solid tumours, including lung cancer. However, the function and mechanism
Publikováno v:
Journal of Cellular and Molecular Medicine
ATP citrate lyase (ACLY), a key enzyme in the metabolic reprogramming of many cancers, is widely expressed in various mammalian tissues. This study aimed to evaluate the effects and mechanisms of ACLY and its inhibitor BMS‐303141 on hepatocellular
Autor:
Jiarun Zhang, Xiuyue Yu, Xiaotong Zhang, Zhe Zhang, Xuejie Li, Chuize Kong, Lei Yin, Jinlong Yao, Yang Liu, Xi Liu, Hao Zhang
Publikováno v:
Journal of Cellular and Molecular Medicine
Much progress has been made in understanding the mechanism of bladder cancer (BC) progression. Protein kinase C‐α (PKCα) is overexpressed in many kinds of cancers. Additionally, PKCα is considered an oncogene that regulates proliferation, invasi