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pro vyhledávání: ''
Autor:
Tadayoshi Okimoto, Takahiro Hiratsuka, Shusaku Kurogi, Masafumi Inomata, Tomohisa Uchida, Daisuke Kakisako, Teijiro Hirashita, Masatsugu Moriyama, Chisato Nakada, Yoshiyuki Tsukamoto, Naoki Hijiya, Yuka Hirashita, Tsuyoshi Etoh, Tomonori Akagi, Masaaki Kodama, Yoshitake Ueda, Kazuhiro Mizukami, Yoko Kudo, Koichi Honda, Kazunari Murakami, Hidefumi Shiroshita
Publikováno v:
Laboratory Investigation. 101:1036-1047
Mutations in RAS or BRAF are associated with poor prognosis and resistance to epidermal growth factor receptor (EGFR)-targeted therapy in colorectal cancer (CRC). Despite their common ability to activate downstream genes such as MEK and ERK, the ther
Autor:
Eric S. Geanes, Sean M. Holloran, Anuradha Roy, Olivia K. Provance, Sumedha Gunewardena, Christy R. Hagan, Scott Weir, Asona Lui, Joan Lewis-Wambi
Publikováno v:
Cancer Lett
Overexpression of interferon induced transmembrane protein-1 (IFITM1) enhances tumor progression in multiple cancers, but its role in triple-negative breast cancer (TNBC) is unknown. Here, we explore the functional significance and regulation of IFIT
Autor:
Liqin Xu, Jia Fan, Yu Zhong, Miaomiao Jiang, Xiao-Rui Zhou, Yong Hou, Geng Liu, Min Du, Guibo Li, Shuang-Jian Qiu, Yuan Ji, Sun Yunfan, Xiangdong Wang, Bo Hu, Ashley R. Dennison, Sheng Liu, Ze-Fan Zhang, Qichao Yu, Xiaoyun Huang, Yang Xu, Ying-Hong Shi, David H. Peng, Wen-Yuan Chung, Kai-Qian Zhou, Nannan Li, Wei Guo, Liang Wu, Jian Zhou, Xin-Rong Yang, Hui-Chuan Sun, Michael Dean, Shiping Liu, Zhikun Zhao
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications
Little is known about the transcriptomic plasticity and adaptive mechanisms of circulating tumor cells (CTCs) during hematogeneous dissemination. Here we interrogate the transcriptome of 113 single CTCs from 4 different vascular sites, including hepa
Autor:
Stephane Ferretti, Sébastien Jeay, Ensar Halilovic, Claire Fabre, Laurence Van Bree, Christophe Meille, Jens Wuerthner, Florence Hourcade-Potelleret, Sebastian Bauer, Reinhard Dummer, Philippe A. Cassier, Astrid Jullion, George D. Demetri, Nelson Guerreiro, Daniel Shao-Weng Tan
Publikováno v:
British Journal of Cancer
Background CGM097 inhibits the p53-HDM2 interaction leading to downstream p53 activation. Preclinical in vivo studies support clinical exploration while providing preliminary evidence for dosing regimens. This first-in-human phase I study aimed at as
Autor:
Masayuki Ohtsuka, Katsunori Furukawa, Yoji Miyahara, Satoshi Kuboki, Satoshi Tomizawa, Mamoru Takada, Tsukasa Takayashiki, Shigetsugu Takano, Kosuke Sasaki
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-16 (2021)
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research : CR
Background Recent studies indicate that complement plays pivotal roles in promoting or suppressing cancer progression. We have previously identified C4b-binding protein α-chain (C4BPA) as a serum biomarker for the early detection of pancreatic ducta
Autor:
Shauli Talmor, Ignacio Mastandrea, Tova Waks, Zelig Eshhar, Liat Rousso-Noori, Dinorah Friedmann-Morvinski, Tambet Teesalu, Maarja Haugas, Luis Álvarez-Vallina, Anat Levin
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Rousso-Noori, L, Mastandrea, I, Talmor, S, Waks, T, Globerson Levin, A, Haugas, M, Teesalu, T, Alvarez-Vallina, L, Eshhar, Z & Friedmann-Morvinski, D 2021, ' P32-specific CAR T cells with dual antitumor and antiangiogenic therapeutic potential in gliomas ', Nature Communications, vol. 12, no. 1, 3615 . https://doi.org/10.1038/s41467-021-23817-2
Nature Communications
Rousso-Noori, L, Mastandrea, I, Talmor, S, Waks, T, Globerson Levin, A, Haugas, M, Teesalu, T, Alvarez-Vallina, L, Eshhar, Z & Friedmann-Morvinski, D 2021, ' P32-specific CAR T cells with dual antitumor and antiangiogenic therapeutic potential in gliomas ', Nature Communications, vol. 12, no. 1, 3615 . https://doi.org/10.1038/s41467-021-23817-2
Nature Communications
Glioblastoma is considered one of the most aggressive malignancies in adult and pediatric patients. Despite decades of research no curative treatment is available and it thus remains associated with a very dismal prognosis. Although recent pre-clinic
Autor:
Qiyuan Li, Chuanhui Lu, Chunlin Ke, Fakun Huang, Rongmu Xia, Yanjun Mi, Yanru Xiao, Jiayi Li, Jun You
Publikováno v:
Oncogene
Emerging evidences suggest that long noncoding RNA (lncRNA) plays a vital role in tumorigenesis and cancer progression. Here, the aim of this study is to investigate the biological function of long intervening noncoding RNA Linc00284 in colorectal ca
Autor:
Chien-Liang Liu, Yuan-Ching Chang, Chun-Yi Wu, Ming-Jen Chen, Wen-Chien Huang, Shih-Ping Cheng, Chi-Hsin Lin, Jiunn-Chang Lin
Publikováno v:
Investigational New Drugs. 39:1493-1506
Background Human 3β-hydroxysteroid dehydrogenase type 1 (HSD3B1) is an enzyme associated with steroidogenesis, however its' role in hepatocellular carcinoma (HCC) biology is unknown. Trilostane is an inhibitor of HSD3B1 and has been tested as a trea
Autor:
James G. Herman, Wushuang Du, Lidong Wang, Shunchang Jiao, Aiai Gao, Lirong Zhang, Mingzhou Guo
Publikováno v:
Cancer Science
Wnt, PI3K‐Akt‐mTOR, and NF‐κB pathways were reported to be involved in DNA damage repair (DDR). DDR‐deficient cancers become critically dependent on backup DNA repair pathways. Neuritin 1 (NRN1) is reported to be involved in PI3K‐Akt‐mTO
Publikováno v:
FEBS Open Bio
FEBS Open Bio, Vol 11, Iss 5, Pp 1487-1496 (2021)
FEBS Open Bio, Vol 11, Iss 5, Pp 1487-1496 (2021)
Bladder cancer is one of the most common malignant tumors of the urinary system, with high morbidity and mortality. At present, the survival rates and prognosis of patients with bladder cancer are still relatively low; thus, there remains a need to i