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Autor:
Eric S. Geanes, Sean M. Holloran, Anuradha Roy, Olivia K. Provance, Sumedha Gunewardena, Christy R. Hagan, Scott Weir, Asona Lui, Joan Lewis-Wambi
Publikováno v:
Cancer Lett
Overexpression of interferon induced transmembrane protein-1 (IFITM1) enhances tumor progression in multiple cancers, but its role in triple-negative breast cancer (TNBC) is unknown. Here, we explore the functional significance and regulation of IFIT
Autor:
Wenjie Gao, Bo Gao, Xianjian Qiu, Dongsheng Huang, Jincheng Qiu, Pengfei Li, Hang Zhou, Zhancheng Liang, Zhihuai Deng, Wenjun Hu, Tongzhou Liang, Anjing Liang, Shaoguang Li, Taiqiu Chen
Publikováno v:
Mediators of Inflammation
Mediators of Inflammation, Vol 2021 (2021)
Mediators of Inflammation, Vol 2021 (2021)
Intervertebral disc degenerative disease (IDD) is the most common degenerative spine disease, which leads to chronic low back pain and symptoms in the lower extremities. In this study, we found that RORα, a member of the retinoid-related orphan rece
Publikováno v:
Bioscience, Biotechnology, and Biochemistry. 85:1839-1845
DUSP4 is considered as an oncogenic gene. However, the effect of DUSP4 on the carcinogenesis of clear cell Renal cell carcinoma (CCRCC) is still unclear. In this study, DUSP4 mRNA levels were significantly increased in CCRCC tissues and cell lines. F
Autor:
Masayuki Ohtsuka, Katsunori Furukawa, Yoji Miyahara, Satoshi Kuboki, Satoshi Tomizawa, Mamoru Takada, Tsukasa Takayashiki, Shigetsugu Takano, Kosuke Sasaki
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-16 (2021)
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research : CR
Background Recent studies indicate that complement plays pivotal roles in promoting or suppressing cancer progression. We have previously identified C4b-binding protein α-chain (C4BPA) as a serum biomarker for the early detection of pancreatic ducta
Autor:
Qiyuan Li, Chuanhui Lu, Chunlin Ke, Fakun Huang, Rongmu Xia, Yanjun Mi, Yanru Xiao, Jiayi Li, Jun You
Publikováno v:
Oncogene
Emerging evidences suggest that long noncoding RNA (lncRNA) plays a vital role in tumorigenesis and cancer progression. Here, the aim of this study is to investigate the biological function of long intervening noncoding RNA Linc00284 in colorectal ca
Autor:
James G. Herman, Wushuang Du, Lidong Wang, Shunchang Jiao, Aiai Gao, Lirong Zhang, Mingzhou Guo
Publikováno v:
Cancer Science
Wnt, PI3K‐Akt‐mTOR, and NF‐κB pathways were reported to be involved in DNA damage repair (DDR). DDR‐deficient cancers become critically dependent on backup DNA repair pathways. Neuritin 1 (NRN1) is reported to be involved in PI3K‐Akt‐mTO
Autor:
Junjie Xu, Liye Tao, Zhongjie Lin, Shunjie Xia, Yifan Wang, Xiao Liang, Liuxin Cai, Zhe Wan, Junhao Zheng, Xiujun Cai, Lin Ji, Yeling Ruan
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-13 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
The treatment for hepatocellular carcinoma (HCC) is promising in recent years, but still facing critical challenges. The first targeted therapy, sorafenib, prolonged the overall survival by months. However, resistance often occurs, largely limits its
Publikováno v:
Translational Research. 231:102-112
Gastric cancer (GC) is a highly prevalent malignancy featured by dismal oncological outcomes. Accumulating pieces of evidence have consensus over the therapeutic significance of extracellular vesicles (EVs) and its role in carcinogenesis. Here, we pl
Publikováno v:
Cancer Immunology, Immunotherapy
Transurethral resection of the tumor (TUR-B) followed by adjuvant intravesical treatment with cytostatic drugs or Bacillus Calmette–Guérin (BCG) as standard therapy of non-muscle-invasive bladder cancer (NMIBC) is associated with a high recurrence
Autor:
Zou Zizheng, Fan-Rong Kong, Chuanyu Yang, Chen Ling, Hu Xiyuan, Da-You Ma, Kun-Jian Peng, Xuan Li, Dong-Sheng Cao, Ceshi Chen, Tiao Luo, Zhengnan Ming, Wenjun Yi, Chen Xiaodan, Su-You Liu, Zhiyong Luo, Li Xia, Yuan-Zhu Xie, Jijia Li, Ousheng Liu, Junli Luo, Na Xu, Luo Wensong, Min Wen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
Argininosuccinate synthase (ASS1) is a ubiquitous enzyme in mammals that catalyzes the formation of argininosuccinate from citrulline and aspartate. ASS1 genetic deficiency in patients leads to an autosomal recessive urea cycle disorder citrullinemia