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Publikováno v:
Cold Spring Harb Perspect Med
While commendable strides have been made in reducing smoking initiation and improving smoking cessation rates, current available smoking cessation treatment options are still only mildly efficacious and show substantial interindividual variability in
Publikováno v:
Scientific Reports. 13
Deficits in arousal and stress responsiveness are a feature of numerous psychiatric disorders including depression and anxiety. Arousal is supported by norepinephrine (NE) released from specialized brainstem nuclei, including the locus coeruleus (LC)
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 3, p e0193853 (2018)
PLoS ONE, Vol 13, Iss 3, p e0193853 (2018)
17β-estradiol treatment has shown benefit against schizophrenia symptoms, however longterm use may be associated with negative side-effects. Selective estrogen receptor modulators, such as raloxifene and tamoxifen, have been proposed as suitable alt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::011797b2121308140f7e5e9e0a964b89
Autor:
S.H. Burchynskyi
Publikováno v:
INTERNATIONAL NEUROLOGICAL JOURNAL; № 1.79 (2016); 69-77
МЕЖДУНАРОДНЫЙ НЕВРОЛОГИЧЕСКИЙ ЖУРНАЛ; № 1.79 (2016); 69-77
МІЖНАРОДНИЙ НЕВРОЛОГІЧНИЙ ЖУРНАЛ; № 1.79 (2016); 69-77
МЕЖДУНАРОДНЫЙ НЕВРОЛОГИЧЕСКИЙ ЖУРНАЛ; № 1.79 (2016); 69-77
МІЖНАРОДНИЙ НЕВРОЛОГІЧНИЙ ЖУРНАЛ; № 1.79 (2016); 69-77
The article deals with the treatment of dementia. The place of memantine, a drug of the adamantane group, a low affinity, non-competitive NMDA receptor antagonist, in the treatment of this disease is considered in detail. It is emphasized that memant
Autor:
Dana M. Smith, Victoria L. DiBona, David P. Crockett, Huaye Zhang, Mikayla M. Voglewede, Kayla J. Krause, Wenxin Zhu, Mihir Shah
Publikováno v:
Neurosci Res
Within the brain, traumatic brain injury (TBI) alters synaptic plasticity and increases neuroinflammation and neuronal death. Yet, there lacks effective TBI treatments providing pleiotropic beneficial effects on these diverse cellular processes neces
Autor:
Keith M. Kendrick, Yina Ma, Shuxia Yao, Lei Xu, Ning Yang, Keshuang Li, Dirk Scheele, Benjamin Becker, Chunmei Lan, Xue Yong, Feng Zhou, Congcong Liu, Jiaxin Yang
Publikováno v:
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 6:1081-1089
BackgroundOverarching conceptualizations propose that the complex social-emotional effects of oxytocin (OXT) in humans are partly mediated by interactions with other neurotransmitter systems. Recent animal models suggest that the anxiolytic effects o
Publikováno v:
Neuroscience
Altered brain metabolism contributes to pathophysiology in cerebrovascular and neurodegenerative diseases such as stroke and Alzheimer’s disease. Current clinical tools to study brain metabolism rely on positron emission tomography (PET) requiring
Autor:
Gordon D. Waiter, Claire Green, Mathew A. Harris, J. Douglas Steele, Anca-Larisa Sandu, Joanna M. Wardlaw, David J. Porteous, Heather C. Whalley, Liana Romaniuk, Emma L. Hawkins, Rebecca M. Reynolds, Xueyi Shen, Miruna C. Barbu, Aleks Stolicyn, Jonathan R. Seckl, Andrew M. McIntosh, Stephen M. Lawrie, Jonathan Cavanagh, Archie Campbell
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-9 (2021)
Translational Psychiatry
Green, C, Stolicyn, A, Harris, M A, Shen, X, Romaniuk, L, Barbu, M C, Hawkins, E L, Wardlaw, J M, Steele, J D, Waiter, G D, Sandu, A, Campbell, A, Porteous, D J, Seckl, J R, Lawrie, S M, Reynolds, R M, Cavanagh, J, Mcintosh, A M & Whalley, H C 2021, ' Hair glucocorticoids are associated with childhood adversity, depressive symptoms and reduced global and lobar grey matter in Generation Scotland ', Translational Psychiatry, vol. 11, no. 1 . https://doi.org/10.1038/s41398-021-01644-9
Translational Psychiatry
Green, C, Stolicyn, A, Harris, M A, Shen, X, Romaniuk, L, Barbu, M C, Hawkins, E L, Wardlaw, J M, Steele, J D, Waiter, G D, Sandu, A, Campbell, A, Porteous, D J, Seckl, J R, Lawrie, S M, Reynolds, R M, Cavanagh, J, Mcintosh, A M & Whalley, H C 2021, ' Hair glucocorticoids are associated with childhood adversity, depressive symptoms and reduced global and lobar grey matter in Generation Scotland ', Translational Psychiatry, vol. 11, no. 1 . https://doi.org/10.1038/s41398-021-01644-9
Hypothalamic–pituitary–adrenal (HPA) axis dysregulation has been commonly reported in major depressive disorder (MDD), but with considerable heterogeneity of results; potentially due to the predominant use of acute measures of an inherently varia
Neural Responses to Fluoxetine in Youths with Disruptive Behavior and Trauma Exposure: A Pilot Study
Autor:
Eun Ji Kim, Ji Woo Suk, Yongmin Chang, Ellen Leibenluft, Harma Meffert, Soonjo Hwang, James R. Blair, Christopher J. Kratochvil, Un-Sun Chung
Publikováno v:
Journal of Child and Adolescent Psychopharmacology
Objective: A preliminary investigation of the impact of a serotonergic agent (fluoxetine) on symptom profile and neural response in youths with disruptive behavior disorders (DBDs) and a history of trauma exposure. Methods: There were three participa
Publikováno v:
Current Molecular Pharmacology. 14:263-280
Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease (MND) characterized by the death of upper and lower motor neurons (corticospinal tract) in the motor cortex, basal ganglia, brain stem, and spinal cord. The patient experiences the s