Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Patrick Rabe"'
Autor:
Timothy Armistead, Karina Calvopiña, Michael A. McDonough, Catherine L. Tooke, Patrick Rabe, James Spencer, Tika R. Malla, Allen M. Orville, Christopher J. Schofield, Philip Hinchliffe, Anka Lucic, Christopher T Lohans, Jürgen Brem
Publikováno v:
Eur J Med Chem
Lucic, A, Hinchliffe, P, Malla, T R, Tooke, C L, Brem, J, Calvopiña, K, Lohans, C T, Rabe, P, McDonough, M A, Armistead, T, Orville, A M, Spencer, J & Schofield, C J 2021, ' Faropenem reacts with serine and metallo-β-lactamases to give multiple products ', European Journal of Medicinal Chemistry, vol. 215, 113257 . https://doi.org/10.1016/j.ejmech.2021.113257
Lucic, A, Hinchliffe, P, Malla, T R, Tooke, C L, Brem, J, Calvopiña, K, Lohans, C T, Rabe, P, McDonough, M A, Armistead, T, Orville, A M, Spencer, J & Schofield, C J 2021, ' Faropenem reacts with serine and metallo-β-lactamases to give multiple products ', European Journal of Medicinal Chemistry, vol. 215, 113257 . https://doi.org/10.1016/j.ejmech.2021.113257
Penems have demonstrated potential as antibacterials and β-lactamase inhibitors; however, their clinical use has been limited, especially in comparison with the structurally related carbapenems. Faropenem is an orally active antibiotic with a C2 tet
Publikováno v:
European Journal of Organic Chemistry. 2019:351-359
Publikováno v:
Angewandte Chemie. 130:3292-3296
Publikováno v:
Angewandte Chemie International Edition. 57:3238-3241
Two bacterial diterpene synthases from the actinomycete Allokutzneria albata were investigated, resulting in the identification of the structurally unprecedented compound spiroalbatene from the first and cembrene A from the second enzyme. Both enzyme
Publikováno v:
Chemistry - A European Journal. 23:10501-10505
Two diterpene cyclases, one from the social amoeba Dictyostelium discoideum and the other from the bacterium Streptomyces clavuligerus, with products containing a Z-configured double bond between the original C2 and C3 of geranylgeranyl diphosphate,
Autor:
Etilia Dolja, Thomas Schmitz, T. Hoang Luu, Patrick Rabe, Britta Nubbemeyer, Jeroen S. Dickschat, Jan Rinkel
Publikováno v:
Angewandte Chemie. 129:2820-2823
Die Mechanismen von zwei Diterpencyclasen aus Streptomyceten – eine mit unbekanntem Produkt, das als der spirocyclische Kohlenwasserstoff Spiroviolen identifiziert wurde, und eine mit dem bekannten Produkt Tsukubadien – wurden detailliert durch I
Autor:
Etilia Dolja, Patrick Rabe, Jan Rinkel, Britta Nubbemeyer, Jeroen S. Dickschat, T. Hoang Luu, Thomas Schmitz
Publikováno v:
Angewandte Chemie International Edition. 56:2776-2779
The mechanisms of two diterpene cyclases from streptomycetes-one with an unknown product that was identified as the spirocyclic hydrocarbon spiroviolene and one with the known product tsukubadiene-were investigated in detail by isotope labeling exper
Publikováno v:
Organic & Biomolecular Chemistry. 15:2353-2358
Genome sequencing of Streptomyces malaysiensis DSM 4137 revealed the presence of four terpene cyclase genes, one of which was characterised as (+)-isoafricanol synthase. Its cyclisation mechanism was extensively studied using isotopically labelled pr
Autor:
Feng Chen, Patrick Rabe, Tobias G. Köllner, Jeroen S. Dickschat, Britta Nubbemeyer, Jan Rinkel
Publikováno v:
Angewandte Chemie International Edition. 55:15420-15423
Genome sequences of social amoebae reveal the presence of terpene cyclases (TCs) in these organisms. Two TCs from Dictyostelium discoideum converted farnesyl diphosphate into (2S,3R,6S,9S)-(-)-protoillud-7-ene and (3S)-(+)-asterisca-2(9),6-diene. The
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 12, Iss 1, Pp 2317-2324 (2016)
The stereochemical course of the cyclisation reaction catalysed by the bacterial 1,8-cineol synthase from Streptomyces clavuligerus was investigated using stereospecifically deuterated substrates. In contrast to the well investigated plant enzyme fro