Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Betül Kaya Çavuşoğlu"'
Autor:
Begüm Nurpelin Sağlık, Zafer Asım Kaplancıklı, Yusuf Özkay, Derya Osmaniye, Serkan Levent, Ulviye Acar Çevik, Betül Kaya Çavuşoğlu
Publikováno v:
RSC Med Chem
Monoamine oxidases (MAOs) are important drug targets for the management of neurological disorders. Herein, a series of new 1,3,4-thiadiazole derivatives bearing various alkyl/arylamine moieties as MAO inhibitors were designed and synthesized. All of
Autor:
Zafer Asım Kaplancıklı, Derya Osmaniye, Betül Kaya Çavuşoğlu, Yusuf Özkay, Serkan Levent, Ali Savaş Koparal, Özlem Atlı Eklioğlu, Ulviye Acar Çevik, Begüm Nurpelin Sağlık
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1422-1432 (2020)
Many studies have been conducted on the selective inhibition of human monoamine oxidase B (hMAO-B) enzyme using benzylamine-sulphonamide derivatives. Using various chemical modifications on BB-4h, which was reported previously by our team and showed
Autor:
Ulviye Acar Çevik, Yusuf Özkay, Begüm Nurpelin Sağlık, Derya Osmaniye, Zafer Asım Kaplancıklı, Betül Kaya Çavuşoğlu, Sinem Ilgın, Serkan Levent
Publikováno v:
Molecules, Vol 25, Iss 1642, p 1642 (2020)
Molecules
Volume 25
Issue 7
Molecules
Volume 25
Issue 7
In the last step of estrogen biosynthesis, aromatase enzyme catalyzes the conversion of androgens to estrogens. Aromatase inhibition is an important way to control estrogen-related diseases and estrogen levels. In this study, sixteen of benzimidazole
Autor:
Serkan Levent, Zafer Asım Kaplancıklı, Gülhan Turan, Yusuf Özkay, Derya Osmaniye, Begüm Nurpelin Sağlık, Sinem Ilgın, Ahmet Cagri Karaburun, Betül Kaya Çavuşoğlu, Ulviye Acar Çevik, Abdullah Burak Karaduman
WOS: 000528119400002
Multitarget molecules are considered as an effective way for the treatment of AD, instead of the classic one-drug-one-target strategy because of the multifactorial nature of AD. A variety of studies indicate that several enz
Multitarget molecules are considered as an effective way for the treatment of AD, instead of the classic one-drug-one-target strategy because of the multifactorial nature of AD. A variety of studies indicate that several enz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ec72e76dbccd87e890d28f23822af60
https://hdl.handle.net/11421/23963
https://hdl.handle.net/11421/23963
Autor:
Zafer Asim Kaplancikl, Yusuf Özkay, Derya Osmaniye, Ulviye Acar Çevik, Serkan Levent, Betül Kaya Çavuşoğlu, Begüm Nurpelin Sağlık
Publikováno v:
Heterocyclic Communications, Vol 26, Iss 1, Pp 6-13 (2020)
WOS: 000518798900001
Cancer is one of the most common causes of death in the world. Despite the importance of combating cancer in healthcare systems and research centers, toxicity in normal tissues and the low efficiency of anticancer drugs are
Cancer is one of the most common causes of death in the world. Despite the importance of combating cancer in healthcare systems and research centers, toxicity in normal tissues and the low efficiency of anticancer drugs are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::086ccd92e340f3a0f37d893929841afd
https://hdl.handle.net/11421/24028
https://hdl.handle.net/11421/24028
Autor:
Ulviye Acar Çevik, Begüm Nurpelin Sağlık, Abdullah Burak Karaduman, Derya Osmaniye, Yusuf Özkay, Serkan Levent, Betül Kaya Çavuşoğlu, Zafer Asım Kaplancıklı
Publikováno v:
Acta Pharmaceutica, Vol 70, Iss 4, Pp 499-513 (2020)
WOS: 000535907700005
PubMed: 32412436
The synthesis of new N-(5-substituted-1,3,4-thiadiazol-2-yl)-2-[5-(substituted amino)-1,3,4-thiadiazol-2-yl)thiolacetamide derivatives and investigation of their anticancer activities were the aims of t
PubMed: 32412436
The synthesis of new N-(5-substituted-1,3,4-thiadiazol-2-yl)-2-[5-(substituted amino)-1,3,4-thiadiazol-2-yl)thiolacetamide derivatives and investigation of their anticancer activities were the aims of t
Publikováno v:
Bioorganic Chemistry. 76:177-187
WOS: 000425897800018
PubMed ID: 29175589
A new series of thirteen 2-[(4-fluorophenyl)(4-nitrobenzyl) amino]-2-oxoethyl-1-substituted-carbodithio ate derivatives (4a-4m) were synthesized and tested for their human monoamine oxidase A and B (
PubMed ID: 29175589
A new series of thirteen 2-[(4-fluorophenyl)(4-nitrobenzyl) amino]-2-oxoethyl-1-substituted-carbodithio ate derivatives (4a-4m) were synthesized and tested for their human monoamine oxidase A and B (
Autor:
Yusuf Özkay, Derya Osmaniye, Zafer Asım Kaplancıklı, Betül Kaya Çavuşoğlu, Begüm Nurpelin Sağlık, Ulviye Acar Çevik, Serkan Levent
Publikováno v:
Molecules
Volume 24
Issue 5
Molecules, Vol 24, Iss 5, p 861 (2019)
Volume 24
Issue 5
Molecules, Vol 24, Iss 5, p 861 (2019)
Alzheimer&rsquo
s disease (AD), one of the main causes of aged dementia, is a progressive and degenerative neurological disorder characterized by loss of cognition and memory. Although the symptomatic treatment of AD, particularly acetylcholines
s disease (AD), one of the main causes of aged dementia, is a progressive and degenerative neurological disorder characterized by loss of cognition and memory. Although the symptomatic treatment of AD, particularly acetylcholines
Autor:
Begüm Nurpelin Sağlık, Derya Osmaniye, Ulviye Acar Çevik, Yusuf Öztürk, Zafer Asım Kaplancıklı, Serkan Levent, Yusuf Özkay, Betül Kaya Çavuşoğlu, Sinem Ilgın
WOS: 000462472500010
PubMed ID: 30605888
New twenty compounds bearing thiazole ring (3a-3t) were designed and synthesized as monoamine oxidase (MAO) inhibitors. The fluorometric enzyme inhibition assay was used to determine the biological e
PubMed ID: 30605888
New twenty compounds bearing thiazole ring (3a-3t) were designed and synthesized as monoamine oxidase (MAO) inhibitors. The fluorometric enzyme inhibition assay was used to determine the biological e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f4a3a0607e49e3910580e5db5002c9f
https://hdl.handle.net/11421/13601
https://hdl.handle.net/11421/13601
Autor:
Ulviye Acar Çevik, Derya Osmaniye, Şükrü Beydemir, Yusuf Özkay, Serkan Levent, Betül Kaya Çavuşoğlu, Zafer Asım Kaplancıklı, Begüm Nurpelin Sağlık, Yeliz Demir, Ali Savaş Koparal, Sinem Ilgın
Publikováno v:
Bioorganic chemistry. 91
PubMed: 31382057
New sulfonamide-hydrazone derivatives (3a-3n) were synthesized to evaluate their inhibitory effects on purified human carbonic anhydrase (hCA) I and II. The inhibition profiles of the synthesized compounds on hCA I-II isoenzyme
New sulfonamide-hydrazone derivatives (3a-3n) were synthesized to evaluate their inhibitory effects on purified human carbonic anhydrase (hCA) I and II. The inhibition profiles of the synthesized compounds on hCA I-II isoenzyme